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Drug Resistance in Leishmania Parasites pp 237–258Cite as

The Role of ABC Transporters in Drug-Resistant Leishmania

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Summary

The ATP-binding cassette (ABC) transporters belong to the largest family of transmembrane proteins found in living organisms. These proteins are present in prokaryotes and eukaryotes and are mainly involved in the transport of a variety of molecules across cellular membranes, whereas others are involved in biological processes unrelated to transport. The recent sequencing of the Leishmania species genome confirmed the presence of representatives, also called as members, for all eight different subfamilies (ABCA to ABCH), according to their specific functional and molecular characteristics. These proteins have recently been characterized in Leishmania; some of them associated with drug resistance. This is a significant field in leishmaniasis chemotherapy, a disease still lacking effective treatment and with increasing daily reports of therapeutic failure. In this chapter, we focus our discussion on the association of these proteins with drug resistance in leishmaniasis and its fundamental role in the pathology and pharmacology of this medically important protozoan parasite that currently infects around 12 million people in the world.

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  1. Instituto de Medicina Tropical – São Paulo University Medical School, Av. Dr. Enéas de Carvalho Aguiar, 470 – 4º andar, São Paulo, SP, 05403-000, Brazil

    Adriano C. Coelho & Paulo C. Cotrim

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  1. Adriano C. Coelho
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  2. Paulo C. Cotrim
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Correspondence to Paulo C. Cotrim .

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  1. Fac. Medicina, Instituto de Medicina Experimental, Universidad Central de Venezuela, Caracas, 1062, Venezuela

    Alicia Ponte-Sucre

  2. Universidad Central de Venezuela, ciudad universitaria, Caracas, 1062, Venezuela

    Emilia Diaz

  3. Universidad Central de Venezuela, ciudad universitaria, Caracas, 1062, Venezuela

    Maritza Padrón-Nieves

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Coelho, A.C., Cotrim, P.C. (2013). The Role of ABC Transporters in Drug-Resistant Leishmania . In: Ponte-Sucre, A., Diaz, E., Padrón-Nieves, M. (eds) Drug Resistance in Leishmania Parasites. Springer, Vienna. https://doi.org/10.1007/978-3-7091-1125-3_12

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  • DOI: https://doi.org/10.1007/978-3-7091-1125-3_12

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