Skip to main content
SpringerLink
Log in

Galectin-1: Forms and Functions

  • Chapter
  • First Online:
Animal Lectins: Form, Function and Clinical Applications

  • 1616 Accesses

Abstract

Galectin-1 (Gal-1) is an animal lectin ranging from Caenorhabditis elegans to humans, which is defined by the affinity for β-galactosides and by significant sequence similarity in carbohydrate-binding site. Gal-1 is differentially expressed by various normal and pathological tissues and appears to be functionally polyvalent, with a wide range of biological activity. Evidences indicate that Gal-1 and its ligands are important regulators of immune responses such as T-cell homeostasis and survival, inflammation and allergies as well as host–pathogen interactions. Over-expression of Gal-1 in tumors is considered as a sign of the malignant tumor progression that is often related to the long-range dissemination of tumoral cells (metastasis), to their dissemination into the surrounding normal tissue, and to tumor immune-escape. Gal-1 in its oxidized form plays a number of important roles in the regeneration of the central nervous system after injury. The targeted overexpression of Gal-1 should be considered as a method of choice for the treatment of some kinds of inflammation-related diseases, neurodegenerative pathologies and muscular dystrophies. In contrast, the targeted inhibition of Gal-1 expression is what should be developed for therapeutic applications against cancer progression. Gal-1 is thus a promising molecular target for the development of new and original therapeutic tools.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 259.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 329.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 329.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Adams L, Scott GK, Weinberg CS (1996) Biphasic modulation of cell growth by recombinant human galectin-1. Biochim Biophys Acta 1312:137–144

    Article  PubMed  Google Scholar 

  • Ahmad N, Gabius HJ, Sabesan S et al (2004) Thermodynamic binding studies of bivalent oligosaccharides to galectin-1, galectin-3, and the carbohydrate recognition domain of galectin-3. Glycobiology 14:817–825

    Article  PubMed  CAS  Google Scholar 

  • Ahmed H, Pohl J, Fink NE et al (1996) The primary structure and carbohydrate specificity of a β-galactosyl-binding lectin from toad (Bufo arenarum Hensel) ovary reveal closer similarities to the mammalian galectin-1 than to the galectin from the clawed frog Xenopus laevis. J Biol Chem 271:33083–33094

    Article  PubMed  CAS  Google Scholar 

  • Ahmed H, Vasta GR (1994) Galectins: conservation of functionally and structurally relevant amino acid residues defines two types of carbohydrate recognition domains. Glycobiology 4:545–548

    Article  PubMed  CAS  Google Scholar 

  • Ahmed H, Vasta GR (2008) Unlike mammalian GRIFIN, the zebrafish homologue (DrGRIFIN) represents a functional carbohydrate-binding galectin. Biochem Biophys Res Commun 371:350–355

    Article  PubMed  CAS  Google Scholar 

  • Ahmed H, Du SJ, Vasta GR (2009) Knockdown of a galectin-1-like protein in zebrafish (Danio rerio) causes defects in skeletal muscle development. Glycoconj J 26:277–283

    Article  PubMed  CAS  Google Scholar 

  • Akama K, Tatsuno R, Otsu M, Inoue N et al (2008) Proteomic identification of differentially expressed genes in mouse neural stem cells and neurons differentiated from embryonic stem cells in vitro. Biochim Biophys Acta 1784:773–782

    Article  PubMed  CAS  Google Scholar 

  • Akazawa C, Nakamura Y, Sango K et al (2004) Distribution of the galectin-1 mRNA in the rat nervous system: its transient upregulation in rat facial motor neurons after facial nerve axotomy. Neuroscience 125:171–178

    Article  PubMed  CAS  Google Scholar 

  • Almkvist J, Karlsson A (2004) Galectins as inflammatory mediators. Glycoconj J 19:575–581

    Article  PubMed  Google Scholar 

  • Almkvist J, Faldt J, Dahlgren C et al (2001) Lipopolysaccharide-induced gelatinase granule mobilization primes neutrophils for activation by galectin-3 and formylmethionyl-Leu-Phe. Infect Immun 69:832–837

    Article  PubMed  CAS  Google Scholar 

  • Amano M, Galvan M, He J, Baum LG (2003) The ST6Gal I sialyltransferase selectively modifies N-glycans on CD45 to negatively regulate galectin-1-induced CD45 clustering, phosphatase modulation, and T cell death. J Biol Chem 278:7469–7475

    Article  PubMed  CAS  Google Scholar 

  • Andersen H, Jensen ON, Moiseeva EP, Eriksen EF (2003) A proteome study of secreted prostatic factors affecting osteoblastic activity: galectin-1 is involved in differentiation of human bone marrow stromal cells. J Bone Miner Res 18:195–203

    Article  PubMed  CAS  Google Scholar 

  • Andre S, Kaltner H, Furuike T et al (2004) Persubstituted cyclodextrin-based glycoclusters as inhibitors of protein-carbohydrate recognition using purified plant and mammalian lectins and wild-type and lectin-gene-transfected tumor cells as targets. Bioconjug Chem 15:87–98

    Article  PubMed  CAS  Google Scholar 

  • Ashery U, Yizhar O, Rotblat B et al (2006) Spatiotemporal organization of Ras signaling: rasosomes and the galectin switch. Cell Mol Neurobiol 26:471–495

    Article  PubMed  CAS  Google Scholar 

  • Avni O, Pur Z, Yefenof E, Baniyash M (1998) Complement receptor, 3 of macrophages is associated with galectin-1-like protein. J Immunol 160:6151–6158

    PubMed  CAS  Google Scholar 

  • Baggiolini M, Clark-Lewis I (1992) Interleukin-8, a chemotactic and inflammatory cytokine. FEBS Lett 307:97–101

    Article  PubMed  CAS  Google Scholar 

  • Barondes SH, Castronovo V, Cooper DN et al (1994) Galectins: a family of animal β-galactoside-binding lectins. Cell 76:597–598

    Article  PubMed  CAS  Google Scholar 

  • Barrionuevo P, Beigier-Bompadre M, Ilarregui JM et al (2007) A novel function for galectin-1 at the crossroad of innate and adaptive immunity: galectin-1 regulates monocyte/macrophage physiology through a nonapoptotic ERK-dependent pathway. J Immunol 178:436–445

    PubMed  CAS  Google Scholar 

  • Battig P, Saudan P, Gunde T, Bachmann MF (2004) Enhanced apoptotic activity of a structurally optimized form of galectin-1. Mol Immunol 41:9–18

    Article  PubMed  CAS  Google Scholar 

  • Baum LG, Seilhamer JJ, Pang M et al (1995) Synthesis of an endogeneous lectin, galectin-1, by human endothelial cells is up-regulated by endothelial cell activation. Glycoconj J 12:63–68

    Article  PubMed  CAS  Google Scholar 

  • Berberat PO, Friess H, Wang L et al (2001) Comparative analysis of galectins in primary tumors and tumor metastasis in human pancreatic cancer. J Histochem Cytochem 49:539–549

    Article  PubMed  CAS  Google Scholar 

  • Bianchet MA, Ahmed H, Vasta GR, Amzel LM (2000) Soluble β-galactosyl-binding lectin (galectin) from toad ovary: crystallographic studies of two protein-sugar complexes. Proteins 40:378–388

    Article  PubMed  CAS  Google Scholar 

  • Biron VA, Iglesias MM, Troncoso MF, Besio-Moreno M, Patrignani ZJ, Pignataro OP, Wolfenstein-Todel C (2006) Galectin-1: biphasic growth regulation of Leydig tumor cells. Glycobiology 16:810–821

    Article  PubMed  CAS  Google Scholar 

  • Blixt O, Head S et al (2004) Printed covalent glycan array for ligand profiling of diverse glycan binding proteins. Proc Natl Acad Sci USA 101:17033–17038

    Article  PubMed  CAS  Google Scholar 

  • Blois SM, Ilarregui JM, Tometten M et al (2007) A pivotal role for galectin-1 in fetomaternal tolerance. Nat Med 13:1450–1457

    Article  PubMed  CAS  Google Scholar 

  • Bochner BS, Alvarez RA, Mehta P et al (2005) Glycan array screening reveals a candidate ligand for Siglec-8. J Biol Chem 280:4307–4312

    Article  PubMed  CAS  Google Scholar 

  • Bouffard DY, Momparler LF, Momparler RL (1994) Enhancement of the antileukemic activity of 5-aza-2′-deoxycytidine by cyclopentenyl cytosine in HL-60 leukemic cells. Anticancer Drugs 5:223–228

    Article  PubMed  CAS  Google Scholar 

  • Bozic M, Petronijevic M et al (2004) Galectin-1 and galectin-3 in the trophoblast of the gestational trophoblastic disease. Placenta 25:797–802

    Article  PubMed  CAS  Google Scholar 

  • Brandt B, Büchse T, Abou-Eladab EF et al (2008) Galectin-1 induced activation of the apoptotic death-receptor pathway in human Jurkat T lymphocytes. Histochem Cell Biol 129:599–609

    Article  PubMed  CAS  Google Scholar 

  • Brandt B, Abou-Eladab EF et al (2010) Role of the JNK/c-Jun/AP-1 signaling pathway in galectin-1-induced T-cell death. Cell Death Dis 1:e23

    Article  PubMed  CAS  Google Scholar 

  • Brewer FC (2002) Binding and cross-linking properties of galectins. Biochim Biophys Acta 1572:255–262

    Article  Google Scholar 

  • Brewer CF (2004) Thermodynamic binding studies of galectin-1,-3 and -7. Glycoconj J 19:459–465

    Article  PubMed  Google Scholar 

  • Broker LE, Kruyt FA, Giaccone G (2005) Cell death independent of caspases: a review. Clin Cancer Res 11:3155–3162

    Article  PubMed  Google Scholar 

  • Calame KL, Lin KI et al (2003) Regulatory mechanisms that determine the development and function of plasma cells. Annu Rev Immunol 21:205–230

    Article  PubMed  CAS  Google Scholar 

  • Camby I, Belot N, Rorive S et al (2001) Galectins are differentially expressed in supratentorial pilocytic astrocytomas, astrocytomas, anaplastic astrocytomas and glioblastomas, and significantly modulate tumor astrocyte migration. Brain Pathol 11:12–26

    Article  PubMed  CAS  Google Scholar 

  • Camby I, Belot N, Lefranc F et al (2002) Galectin-1 modulates human glioblastoma cell migration into the brain through modifications to the actin cytoskeleton and levels of expression of small GTPases. J Neuropathol Exp Neurol 61:585–596

    PubMed  CAS  Google Scholar 

  • Camby I, Decaestecker C, Lefranc F et al (2005) Galectin-1 knocking down in human U87 glioblastoma cells alters their gene expression pattern. Biochem Biophys Res Commun 335:27–35

    Article  PubMed  CAS  Google Scholar 

  • Camby I, Mercier ML, Lefranc F, Kiss R (2006) Galectin-1: a small protein with major functions. Glycobiology 16:137R–157R

    Article  PubMed  CAS  Google Scholar 

  • Carsons S, Lavietes BB, Slomiany A et al (1987) Carbohydrate heterogeneity of fibronectins. Synovial fluid fibronectin resembles the form secreted by cultured synoviocytes but differs from the plasma form. J Clin Invest 80:1342–1349

    Article  PubMed  CAS  Google Scholar 

  • Cerri DG, Rodrigues LC, Stowell SR et al (2008) Degeneration of dystrophic or injured skeletal muscles induces high expression of galectin-1. Glycobiology 18:842–850

    Article  PubMed  CAS  Google Scholar 

  • Chadli A, LeCaer JP, Bladier D et al (1997) Purification and characterization of a human brain galectin-1 ligand. J Neurochem 68:1640–1647

    Article  PubMed  CAS  Google Scholar 

  • Chang-Hong R, Wada M, Koyama S et al (2005) Neuroprotective effect of oxidized galectin-1 in a transgenic mouse model of amyotrophic lateral sclerosis. Exp Neurol 194:203–211

    Article  PubMed  CAS  Google Scholar 

  • Chang YY, Chen SJ, Liang HC et al (2004) The effect of galectin 1 on 3 T3 cell proliferation on chitosan membranes. Biomaterials 25:3603–3611

    Article  PubMed  CAS  Google Scholar 

  • Chiariotti L, Benvenuto G, Salvatore P et al (1994a) Expression of the soluble lectin L-14 gene is induced by TSH in thyroid cells and suppressed by retinoic acid in transformed neural cells. Biochem Biophys Res Commun 199:540–546

    Article  PubMed  CAS  Google Scholar 

  • Chiariotti L, Benvenuto G, Zarrilli R et al (1994b) Activation of the galectin-1 (L-14-I) gene from nonexpressing differentiated cells by fusion with undifferentiated and tumorigenic cells. Cell Growth Differ 5:769–775

    PubMed  CAS  Google Scholar 

  • Chiariotti L, Berlingieri MT, Battaglia C et al (1995) Expression of galectin-1 in normal human thyroid gland and in differentiated and poorly differentiated thyroid tumors. Int J Cancer 64:171–175

    Article  PubMed  CAS  Google Scholar 

  • Chiariotti L, Salvatore P, Frunzio R, Bruni CB (2004) Galectin genes: regulation of expression. Glycoconj J 19:441–449

    Article  PubMed  Google Scholar 

  • Cho M, Cummings RD (1995) Galectin-1, a β-galactoside-binding lectin in Chinese hamster ovary cells. I. Physical and chemical characterization. J Biol Chem 270:5198–5206

    Article  PubMed  CAS  Google Scholar 

  • Choe YS, Shim C, Choi D et al (1997) Expression of galectin-1 mRNA in the mouse uterus is under the control of ovarian steroids during blastocyst implantation. Mol Reprod Dev 48:261–266

    Article  PubMed  CAS  Google Scholar 

  • Choufani G, Nagy N, Saussez S et al (1999) The levels of expression of galectin-1, galectin-3, and the Thomsen-Friedenreich antigen and their binding sites decrease as clinical aggressiveness increases in head and neck cancers. Cancer 86:2353–2363

    Article  PubMed  CAS  Google Scholar 

  • Choufani G, Ghanooni R, Decaestecker C et al (2001) Detection of macrophage migration inhibitory factor (MIF) in human cholesteatomas and functional implications of correlations to recurrence status and to expression of matrix metalloproteinases-3/9, retinoic acid receptor-β, and anti-apoptotic galectin-3. Laryngoscope 111:1656–1662

    Article  PubMed  CAS  Google Scholar 

  • Chovanec M, Smetana K Jr, Dvorankova B et al (2004) Decrease of nuclear reactivity to growth-regulatory galectin-1 in senescent human keratinocytes and detection of non-uniform staining profile alterations upon prolonged culture for galectin-1 and -3. Anat Histol Embryol 33:348–354

    Article  PubMed  CAS  Google Scholar 

  • Chung CD, Patel VP, Moran M, Lewis LA, Miceli MC (2000) Galectin-1 induces partial TCR zeta-chain phosphorylation and antagonizes processive TCR signal transduction. J Immunol 165:3722–3729

    PubMed  CAS  Google Scholar 

  • Cindolo L, Benvenuto G et al (1999) Galectin-1 and galectin-3 expression in human bladder transitional-cell carcinomas. Int J Cancer 84:39–43

    Article  PubMed  CAS  Google Scholar 

  • Clausse N, van den Brule F, Waltregny D et al (1999) Galectin-1 expression in prostate tumor-associated capillary endothelial cells is increased by prostate carcinoma cells and modulates heterotypic cell-cell adhesion. Angiogenesis 3:317–325

    Article  PubMed  CAS  Google Scholar 

  • Clerch LB, Whitney P, Hass M et al (1988) Sequence of a full-length cDNA for rat lung β-galactoside-binding protein: primary and secondary structure of the lectin. Biochemistry 27:692–29

    Article  PubMed  CAS  Google Scholar 

  • Cooper DN (2002) Galectinomics: finding themes in complexity. Biochim Biophys Acta 1572:209–231

    Article  PubMed  CAS  Google Scholar 

  • Cooper DN, Barondes SH (1990) Evidence for export of a muscle lectin from cytosol to extracellular matrix and for a novel secretory mechanism. J Cell Biol 110:1681–1691

    Article  PubMed  CAS  Google Scholar 

  • D’Haene N, Maris C, Sandras F et al (2005) The differential expression of galectin-1 and galectin-3 in normal lymphoid tissue and non-Hodgkins and Hodgkins lymphomas. Int J Immunopathol Pharmacol 18:431–443

    PubMed  Google Scholar 

  • Daroqui CM, Ilarregui JM, Rubinstein N et al (2007) Regulation of galectin-1 expression by transforming growth factor β1 in metastatic mammary adenocarcinoma cells: implications for tumor-immune escape. Cancer Immunol Immunother 56:491–499

    Article  PubMed  CAS  Google Scholar 

  • Delbrouck C, Doyen I, Belot N et al (2002) Galectin-1 is overexpressed in nasal polyps under budesonide and inhibits eosinophil migration. Lab Invest 82:147–158

    PubMed  CAS  Google Scholar 

  • Dettin L, Rubinstein N, Aoki A et al (2003) Regulated expression and ultrastructural localization of galectin-1, a proapoptotic β-galactoside-binding lectin, during spermatogenesis in rat testis. Biol Reprod 68:51–59

    Article  PubMed  CAS  Google Scholar 

  • Dvorankova B, Smetana K Jr, Chovanec M et al (2005) Transient expression of keratin 19 is induced in originally negative interfollicular epidermal cells by adhesion of suspended cells. Int J Mol Med 16:525–531

    PubMed  CAS  Google Scholar 

  • Earl LA, Bi S, Baum LG (2010) N- and O-glycans modulate galectin-1 binding, CD45 signaling and T cell death. J Biol Chem 285:2232–2244

    Article  PubMed  CAS  Google Scholar 

  • Egnaczyk GF, Pomonis JD, Schmidt JA et al (2003) Proteomic analysis of the reactive phenotype of astrocytes following endothelin-1 exposure. Proteomics 3:689–698

    Article  PubMed  CAS  Google Scholar 

  • Elad-Sfadia G, Haklai R, Ballan E et al (2002) Galectin-1 augments Ras activation and diverts Ras signals to Raf-1 at the expense of phosphoinositide 3-kinase. J Biol Chem 277:37169–37175

    Article  PubMed  CAS  Google Scholar 

  • Ellerhorst J, Nguyen T, Cooper DN et al (1999a) Induction of differentiation and apoptosis in the prostate cancer cell line LNCaP by sodium butyrate and galectin-1. Int J Oncol 14:225–232

    PubMed  CAS  Google Scholar 

  • Ellerhorst J, Nguyen T, Cooper DN et al (1999b) Differential expression of endogenous galectin-1 and galectin-3 in human prostate cancer cell lines and effects of overexpressing galectin-1 on cell phenotype. Int J Oncol 14:217–224

    PubMed  CAS  Google Scholar 

  • Elola MT, Chiesa ME, Alberti AF, Mordoh J, Fink NE (2005a) Galectin-1 receptors in different cell types. J Biomed Sci 12:13–29

    Article  PubMed  CAS  Google Scholar 

  • Elola MT, Chiesa ME et al (2005b) Activation of oxidative burst and degranulation of porcine neutrophils by a homologous spleen galectin-1 compared to N-formyl-L-methionyl-L-leucyl-L-phenylalanine and phorbol 12-myristate 13-acetate. Comp Biochem Physiol B Biochem Mol Biol 141:23–31

    Article  PubMed  CAS  Google Scholar 

  • Endharti AT, Zhou YW, Nakashima I, Suzuki H (2005) Galectin-1 supports survival of naive T cells without promoting cell proliferation. Eur J Immunol 35:86–97

    Article  PubMed  CAS  Google Scholar 

  • Endo T (2005) Glycans and glycan-binding proteins in brain: galectin-1-induced expression of neurotrophic factors in astrocytes. Curr Drug Targets 6:427–436

    Article  PubMed  CAS  Google Scholar 

  • Fajka-Boja R, Szemes M, Ion G et al (2002) Receptor tyrosine phosphatase, CD45 binds galectin-1 but does not mediate its apoptotic signal in T cell lines. Immunol Lett 82:149–154

    Article  PubMed  CAS  Google Scholar 

  • Filén J-J, Nyman TA, Korhonen J et al (2006) Characterization of microsomal fraction proteome in human lymphoblasts reveals the down-regulation of galectin-1 by interleukin-12. Proteomics 5:4719–4732

    Article  CAS  Google Scholar 

  • Fischer C, Sanchez-Ruderisch H, Welzel M et al (2005) Galectin-1 interacts with the α5β1 fibronectin receptor to restrict carcinoma cell growth via induction of p21 and p27. J Biol Chem 280:37266–37277

    Article  PubMed  CAS  Google Scholar 

  • Fitzner B, Walzel H, Sparmann G et al (2005) Galectin-1 is an inductor of pancreatic stellate cell activation. Cell Signal 17:1240–1247

    Article  PubMed  CAS  Google Scholar 

  • Fouillit M, Joubert-Caron R et al (2000) Regulation of CD45-induced signaling by galectin-1 in Burkitt lymphoma B cells. Glycobiology 10:413–419

    Article  PubMed  CAS  Google Scholar 

  • Frigeri LG, Zuberi RI, Lui FT (1993) Epsilon BP, a β-galactoside-binding animal lectin, recognizes IgE receptor (Fc ε RI) and activates mast cells. Biochemistry 32:7644–7649

    Article  PubMed  CAS  Google Scholar 

  • Fukaya K, Hasegawa M, Mashitani T et al (2003) Oxidized galectin-1 stimulates the migration of Schwann cells from both proximal and distal stumps of transected nerves and promotes axonal regeneration after peripheral nerve injury. J Neuropathol Exp Neurol 62:162–172

    PubMed  CAS  Google Scholar 

  • Fukumori T, Takenaka Y, Yoshii T et al (2003) CD29 and CD7 mediate galectin-3-induced type ii t-cell apoptosis. Cancer Res 63:8302–8311

    PubMed  CAS  Google Scholar 

  • Fulcher JA, Hashimi ST, Levroney EL et al (2006) Galectin-1-matured human monocyte-derived dendritic cells have enhanced migration through extracellular matrix. J Immunol 177:216–226

    PubMed  CAS  Google Scholar 

  • Fulcher A, Chang MH, Wang S et al (2009) Galectin-1 co-clusters CD43/CD45 on dendritic cells and induces cell activation and migration through Syk and protein kinase c signaling. J Biol Chem 284:26860–26870

    Article  PubMed  CAS  Google Scholar 

  • Gabius HJ, Andre S, Gunsenhauser I et al (2002) Association of galectin-1- but not galectin-3-dependent parameters with proliferation activity in human neuroblastomas and small cell lung carcinomas. Anticancer Res 22:405–410

    PubMed  Google Scholar 

  • Galindo RC, Ayoubi P, Naranjo V et al (2009) Gene expression profiles of European wild boar naturally infected with Mycobacterium bovis. Vet Immunol Immunopathol 129:119–125

    Article  PubMed  CAS  Google Scholar 

  • Garin MI, Chu CC, Golshayan D, Cernuda-Morollon E, Wait R, Lechler RI (2007) Galectin-1: a key effector of regulation mediated by CD4 + CD25+ T cells. Blood 109:2058–2065

    Article  PubMed  CAS  Google Scholar 

  • Gaudet AD, Steeves JD, Tetzlaff W, Ramer MS (2005) Expression and functions of galectin-1 in sensory and motoneurons. Curr Drug Targets 6:419–425

    Article  PubMed  CAS  Google Scholar 

  • Gaudier E, Forestier L, Gouyer V et al (2004) Butyrate regulation of glycosylation-related gene expression: evidence for galectin-1 upregulation in human intestinal epithelial goblet cells. Biochem Biophys Res Commun 325:1044–1051

    Article  PubMed  CAS  Google Scholar 

  • Gauthier L, Rossi B, Roux F, Termine E, Schiff C (2002) Galectin-1 is a stromal cell ligand of the pre-B cell receptor (BCR) implicated in synapse formation between pre-B and stromal cells and in pre-BCR triggering. Proc Natl Acad Sci USA 99:13014–13019

    Article  PubMed  CAS  Google Scholar 

  • Gillenwater A, Xu XC, Estrov Y et al (1998) Modulation of galectin-1 content in human head and neck squamous carcinoma cells by sodium butyrate. Int J Cancer 75:217–224

    Article  PubMed  CAS  Google Scholar 

  • Gitt MA, Massa SM, Leffler H, Barondes SH (1992) Isolation and expression of a gene encoding L-14-II, a new human soluble lactose-binding lectin. J Biol Chem 267:10601–10606

    PubMed  CAS  Google Scholar 

  • Glinsky VV, Huflejt ME, Glinsky GV et al (2000) Effects of Thomsen-Friedenreich antigen-specific peptide P-30 on β-galactoside-mediated homotypic aggregation and adhesion to the endothelium of MDA-MB-435 human breast carcinoma cells. Cancer Res 60:2584–2588

    PubMed  CAS  Google Scholar 

  • Goldring K, Jones GE, Thiagarajah R, Watt DJ (2002) The effect of galectin-1 on the differentiation of fibroblasts and myoblasts in vitro. J Cell Sci 115:355–366

    PubMed  CAS  Google Scholar 

  • Goldstone SD, Lavin MF (1991) Isolation of a cDNA clone, encoding a human β-galactoside binding protein, overexpressed during glucocorticoid-induced cell death. Biochem Biophys Res Commun 178:746–750

    Article  PubMed  CAS  Google Scholar 

  • Grutzmann R, Pilarsky C, Ammerpohl O et al (2004) Gene expression profiling of microdissected pancreatic ductal carcinomas using high-density DNA microarrays. Neoplasia 6:611–622

    Article  PubMed  CAS  Google Scholar 

  • Gu J, Taniguchi N (2004) Regulation of integrin functions by N-glycans. Glycoconj J 21:9–15

    Article  PubMed  CAS  Google Scholar 

  • Gu M, Wang W, Song WK et al (1994) Selective modulation of the interaction of α7β1 integrin with fibronectin and laminin by L-14 lectin during skeletal muscle differentiation. J Cell Sci 107:175–181

    PubMed  CAS  Google Scholar 

  • Gunnersen JM, Spirkoska V, Smith PE et al (2000) Growth and migration markers of rat C6 glioma cells identified by serial analysis of gene expression. Glia 32:146–154

    Article  PubMed  CAS  Google Scholar 

  • Gupta RK, Pande AH, Gulla KC et al (2006) Carbohydrate-induced modulation of cell membrane. VIII. Agglutination with mammalian lectin galectin-1 increases osmofragility and membrane fluidity of trypsinized erythrocytes. FEBS Lett 580:1691–1695

    Article  PubMed  CAS  Google Scholar 

  • Hahn HP, Pang M, He J, Hernandez JD et al (2004) Galectin-1 induces nuclear translocation of endonuclease G in caspase- and cytochrome c-independent T cell death. Cell Death Differ 11:1277–1286

    Article  PubMed  CAS  Google Scholar 

  • Hansen TV, Hammer NA, Nielsen J et al (2004) Dwarfism and impaired gut development in insulin-like growth factor II mRNA-binding protein 1-deficient mice. Mol Cell Biol 24:4448–4464

    Article  PubMed  CAS  Google Scholar 

  • Harrison FL, Wilson TJ (1992) The 14 kDa β-galactoside binding lectin in myoblast and myotube cultures: localization by confocal microscopy. J Cell Sci 101:635–646

    PubMed  CAS  Google Scholar 

  • Harvey S, Zhang Y, Landry F, Miller C, Smith JW (2001) Insights into a plasma membrane signature. Physiol Genomics 5:129–136

    PubMed  CAS  Google Scholar 

  • He J, Baum LG (2004) Presentation of galectin-1 by extracellular matrix triggers T cell death. J Biol Chem 279:4705–4712

    Article  PubMed  CAS  Google Scholar 

  • He L, Andre S, Siebert HC et al (2003) Detection of ligand- and solvent-induced shape alterations of cell-growth-regulatory human lectin galectin-1 in solution by small angle neutron and X-ray scattering. Biophys J 85:511–524

    Article  PubMed  CAS  Google Scholar 

  • Hernandez JD, Nguyen JT et al (2006) Galectin-1 binds different CD43 glycoforms to cluster CD43 and regulate T cell death. J Immunol 177:5328–5336

    PubMed  CAS  Google Scholar 

  • Hirabayashi J, Kasai K-I (1993) The family of metazoan metal-independent ß-galactoside-binding lectins: structure, function and molecular evolution. Glycobiology 3:297–304

    Article  PubMed  CAS  Google Scholar 

  • Hirabayashi J, Hashidate T, Arata Y et al (2002) Oligosaccharide specificity of galectins: a search by frontal affinity chromatography. Biochim Biophys Acta 1572:232–254

    Article  PubMed  CAS  Google Scholar 

  • Hittelet A, Legendre H, Nagy N et al (2002) Upregulation of galectins-1 and -3 in human colon cancer and their role in regulating cell migration. Int J Cancer 103:370–379

    Article  CAS  Google Scholar 

  • Horie H, Kadoya T (2000) Identification of oxidized galectin-1 as an initial repair regulatory factor after axotomy in peripheral nerves. Neurosci Res 38:131–137

    Article  PubMed  CAS  Google Scholar 

  • Horie H, Kadoya T, Hikawa N et al (2004) Oxidized galectin-1 stimulates macrophages to promote axonal regeneration in peripheral nerves after axotomy. J Neurosci 24:1873–1880

    Article  PubMed  CAS  Google Scholar 

  • Horie H, Kadoya T, Sango K et al (2005) Oxidized galectin-1 is an essential factor for peripheral nerve regeneration. Curr Drug Targets 6:385–394

    Article  PubMed  CAS  Google Scholar 

  • Horiguchi N, Arimoto K, Mizutani A et al (2003) Galectin-1 induces cell adhesion to the extracellular matrix and apoptosis of non-adherent human colon cancer Colo201 cells. J Biochem (Tokyo) 134:869–874

    Article  CAS  Google Scholar 

  • Hsu DK, Yang RY, Pan Z et al (2000) Targeted disruption of the galectin-3 gene results in attenuated peritoneal inflammatory responses. Am J Pathol 156:1073–1083

    Article  PubMed  CAS  Google Scholar 

  • Hughes RC (1999) Secretion of the galectin family of mammalian carbohydrate-binding proteins. Biochim Biophys Acta 1473:172–185

    Article  PubMed  CAS  Google Scholar 

  • Hughes RC (2004) Galectins in kidney development. Glycoconj J 19:621–629

    Article  PubMed  Google Scholar 

  • Hutvagner G, Zamore PD (2002) A microRNA in a multiple-turnover RNAi enzyme complex. Science 297:2056–2060

    Article  PubMed  CAS  Google Scholar 

  • Hynes MA, Gitt M, Barondes SH et al (1990) Selective expression of an endogenous lactose-binding lectin gene in subsets of central and peripheral neurons. J Neurosci 10:1004–1013

    PubMed  CAS  Google Scholar 

  • Ilarregui JM, Bianco GA, Toscano MA et al (2005) The coming of age of galectins as immunomodulatory agents: impact of these carbohydrate binding proteins in T cell physiology and chronic inflammatory disorders. Ann Rheum Dis 64(Suppl 4):96–103

    Google Scholar 

  • Ilarregui JM, Croci DO, Bianco GA et al (2009) Tolerogenic signals delivered by dendritic cells to T cells through a galectin-1-driven immunoregulatory circuit involving interleukin 27 and interleukin 10. Nat Immunol 10:981–991

    Article  PubMed  CAS  Google Scholar 

  • Imbe H, Okamoto K, Kadoya T et al (2003) Galectin-1 is involved in the potentiation of neuropathic pain in the dorsal horn. Brain Res 993:72–83

    Article  PubMed  CAS  Google Scholar 

  • Inagaki Y, Sohma Y, Horie H et al (2000) Oxidized galectin-1 promotes axonal regeneration in peripheral nerves but does not possess lectin properties. Eur J Biochem 267:2955–2964

    Article  PubMed  CAS  Google Scholar 

  • Ion G, Fajka-Boja R, Toth GK et al (2005) Role of p56lck and ZAP70-mediated tyrosine phosphorylation in galectin-1-induced cell death. Cell Death Differ 12:1145–1147

    Article  PubMed  CAS  Google Scholar 

  • Ion G, Fajka-Boja R, Kovacs F et al (2006) Acid sphingomyelinase mediated release of ceramide is essential to trigger the mitochondrial pathway of apoptosis by galectin-1. Cell Signal 18:1887–1896

    Article  PubMed  CAS  Google Scholar 

  • Ishibashi S, Kuroiwa T, Sakaguchi M et al (2007) Galectin-1 regulates neurogenesis in the subventricular zone and promotes functional recovery after stroke. Exp Neurol 207:302–313

    Article  PubMed  CAS  Google Scholar 

  • Jeng KC, Frigeri LG, Liu FT (1994) An endogenous lectin, galectin-3 (epsilon BP/Mac-2), potentiates IL-1 production by human monocytes. Immunol Lett 42:113–116

    Article  PubMed  CAS  Google Scholar 

  • Jeon CH, Kim HL, Park JH (2009) Induction of S100A4, S100A6, and galectin-1 during the lineage commitment of CD4 + CD8+ thymocyte cell line is suppressed by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Lett 187:157–163

    Article  PubMed  CAS  Google Scholar 

  • Jeschke U, Reimer T, Bergemann C et al (2004) Binding of galectin-1 (Gal-1) on trophoblast cells and inhibition of hormone production of trophoblast tumor cells in vitro by Gal-1. Histochem Cell Biol 121:501–508

    Article  PubMed  CAS  Google Scholar 

  • Jeschke U, Karsten U, Wiest I et al (2006) Binding of galectin-1 (Gal-1) to the Thomsen-Friedenreich (TF) antigen on trophoblast cells and inhibition of proliferation of trophoblast tumor cells in vitro by Gal-1 or an anti-TF antibody. Histochem Cell Biol 126:437–444

    Article  PubMed  CAS  Google Scholar 

  • Jeschke U, Mayr D, Schiessl B et al (2007) Expression of galectin-1, -3 (Gal-1, Gal-3) and the Thomsen-Friedenreich (TF) antigen in normal, IUGR, preeclamptic and HELLP placentas. Placenta 28:1165–1173

    Article  PubMed  CAS  Google Scholar 

  • Jeschke U, Walzel H, Mylonas I et al (2009) The human endometrium expresses the glycoprotein mucin-1 and shows positive correlation for thomsen-friedenreich epitope expression and galectin-1 binding. J Histochem Cytochem 57:871–881

    Article  PubMed  CAS  Google Scholar 

  • Joubert R, Caron M, Avellana-Adalid V et al (1992) Human brain lectin: a soluble lectin that binds actin. J Neurochem 58:200–203

    Article  PubMed  CAS  Google Scholar 

  • Kadoya T, Oyanagi K, Kawakami E et al (2005) Oxidized galectin-1 advances the functional recovery after peripheral nerve injury. Neurosci Lett 380:284–288

    Article  PubMed  CAS  Google Scholar 

  • Kami K, Senba E (2005) Galectin-1 is a novel factor that regulates myotube growth in regenerating skeletal muscles. Curr Drug Targets 6:395–405

    Article  PubMed  CAS  Google Scholar 

  • Karmakar S, Cummings RD, McEver RP (2005) Contributions of Ca2+ to galectin-1-induced exposure of phosphatidylserine on activated neutrophils. J Biol Chem 280:28623–28631

    Article  PubMed  CAS  Google Scholar 

  • Karmakar S, Stowell SR, Cummings RD, McEver RP (2008) Galectin-1 signaling in leukocytes requires expression of complex-type N-glycans. Glycobiology 18:770–778

    Article  PubMed  CAS  Google Scholar 

  • Kato T, Ren CH, Wada M et al (2005) Galectin-1 as a potential therapeutic agent for amyotrophic lateral sclerosis. Curr Drug Targets 6:407–418

    Article  PubMed  CAS  Google Scholar 

  • Keller AD, Maniatis T (1992) Only two of the five zinc fingers of the eukaryotic transcriptional repressor PRDI-BF1 are required for sequence-specific DNA binding. Mol Cell Biol 12:1940–1949

    PubMed  CAS  Google Scholar 

  • Klima J, Smetana K Jr et al (2005) Comparative phenotypic characterization of keratinocytes originating from hair follicles. J Mol Histol 36:89–96

    Article  PubMed  CAS  Google Scholar 

  • Koh HS, Lee C, Lee KS et al (2008) CD7 expression and galectin-1-induced apoptosis of immature thymocytes are directly regulated by NF-kB upon T-cell activation. Biochem Biophys Res Commun 370:149–153

    Article  PubMed  CAS  Google Scholar 

  • Koh HS, Lee C, Lee KS et al (2009) Twist2 regulates CD7 expression and galectin-1-induced apoptosis in mature T-cells. Mol Cells 28(6):553–558

    Article  PubMed  CAS  Google Scholar 

  • Kondoh N, Hada A, Ryo A et al (2003) Activation of galectin-1 gene in human hepatocellular carcinoma involves methylation-sensitive complex formations at the transcriptional upstream and downstream elements. Int J Oncol 23:1575–1583

    PubMed  CAS  Google Scholar 

  • Kopitz J, von Reitzenstein C, Burchert M et al (1998) Galectin-1 is a major receptor for ganglioside GM1, a product of the growth-controlling activity of a cell surface ganglioside sialidase, on human neuroblastoma cells in culture. J Biol Chem 273:11205–11211

    Article  PubMed  CAS  Google Scholar 

  • Kopitz J, von Reitzenstein C, Andre S et al (2001) Negative regulation of neuroblastoma cell growth by carbohydrate-dependent surface binding of galectin-1 and functional divergence from galectin-3. J Biol Chem 276:35917–35923

    Article  PubMed  CAS  Google Scholar 

  • Kopitz J, Russwurm R, Kaltner H et al (2004) Hippocampal neurons and recombinant galectins as tools for systematic carbohydrate structure-function studies in neuronal differentiation. Brain Res Dev Brain Res 153:189–196

    Article  PubMed  CAS  Google Scholar 

  • Kopper L, Sebestyen A (2000) Syndecans and the lymphoid system. Leuk Lymphoma 38:271–281

    Article  PubMed  CAS  Google Scholar 

  • Kultima K, Nystrom AM, Scholz B et al (2004) Valproic acid teratogenicity: a toxicogenomics approach. Environ Health Perspect 112:1225–1235

    Article  PubMed  CAS  Google Scholar 

  • Kurushima H, Ohno M, Miura T et al (2005) Selective induction of DeltaFosB in the brain after transient forebrain ischemia accompanied by an increased expression of galectin-1, and the implication of DeltaFosB and galectin-1 in neuroprotection and neurogenesis. Cell Death Differ 12:1078–1096

    Article  PubMed  CAS  Google Scholar 

  • La M, Cao TV, Cerchiaro G et al (2003) A novel biological activity for galectin-1: inhibition of leukocyte–endothelial cell interactions in experimental inflammation. Am J Pathol 163:1505–1515

    Article  PubMed  CAS  Google Scholar 

  • Lefranc F, Tatjana M, Christine D et al (2005) Monitoring the expression profiles of integrins and adhesion/growth-regulatory galectins in adamantinomatous craniopharyngiomas: their ability to regulate tumor adhesiveness to surrounding tissue and their contribution to prognosis. Neurosurgery 56:763–776

    Article  PubMed  Google Scholar 

  • Le Mercier M, Fortin S, Mathieu V et al (2009) Galectin 1 proangiogenic and promigratory effects in the Hs683 oligodendroglioma model are partly mediated through the control of BEX2 expression. Neoplasia 11:485–496

    PubMed  Google Scholar 

  • Lekishvili T, Hesketh S, Brazier MW, Brown DR (2006) Mouse galectin-1 inhibits the toxicity of glutamate by modifying NR1 NMDA receptor expression. Eur J Neurosci 24:3017–3025

    Article  PubMed  Google Scholar 

  • Leppanen A, Stowell S, Blixt O, Cummings RD (2005) Dimeric galectin-1 binds with high affinity to α2,3-sialylated and non-sialylated terminal N-acetyllactosamine units on surface-bound extended glycans. J Biol Chem 280:5549–5562

    Article  PubMed  CAS  Google Scholar 

  • Levroney EL, Aguilar HC, Fulcher JA et al (2005) Novel innate immune functions for galectin-1: galectin-1 inhibits cell fusion by Nipah virus envelope glycoproteins and augments dendritic cell secretion of proinflammatory cytokines. J Immunol 175:413–420

    PubMed  CAS  Google Scholar 

  • Lin KI, Tunyaplin C, Calame K (2003) Transcriptional regulatory cascades controlling plasma cell differentiation. Immunol Rev 194:19–28

    Article  PubMed  CAS  Google Scholar 

  • Liu F-T (2000) Galectins: a new family of regulators of inflammation. Clin Immunol 97:79–88

    Article  PubMed  CAS  Google Scholar 

  • Liu FT, Rabinovich GA (2005) Galectins as modulators of tumour progression. Nat Rev Cancer 5:29–41

    Article  PubMed  CAS  Google Scholar 

  • Liu FT, Patterson RJ, Wang JL (2002) Intracellular functions of galectins. Biochim Biophys Acta 1572:263–273

    Article  PubMed  CAS  Google Scholar 

  • Liu SD, Tomassian T, Bruhn KW, Miller JF, Poirier F, Miceli MC (2009) Galectin-1 tunes TCR binding and signal transduction to regulate CD8 burst size. J Immunol 182:5283–5295

    Article  PubMed  CAS  Google Scholar 

  • Lopez-Lucendo MF, Solis D et al (2004) Growth-regulatory human galectin-1: crystallographic characterisation of the structural changes induced by single-site mutations and their impact on the thermodynamics of ligand binding. J Mol Biol 343:957–970

    Article  PubMed  CAS  Google Scholar 

  • Lu Y, Lotan R (1999) Transcriptional regulation by butyrate of mouse galectin-1 gene in embryonal carcinoma cells. Biochim Biophys Acta 1444:85–91

    Article  PubMed  CAS  Google Scholar 

  • Lu Y, Lotan D, Lotan R (2000) Differential regulation of constitutive and retinoic acid-induced galectin-1 gene transcription in murine embryonal carcinoma and myoblastic cells. Biochim Biophys Acta 1491:13–19

    Article  PubMed  CAS  Google Scholar 

  • Lutomski D, Fouillit M, Bourin P et al (1997) Externalization and binding of galectin-1 on cell surface of K562 cells upon erythroid differentiation. Glycobiology 7:1193–1199

    Article  PubMed  CAS  Google Scholar 

  • Mackay A, Jones C, Dexter T et al (2003) cDNA microarray analysis of genes associated with ERBB2 (HER2/neu) overexpression in human mammary luminal epithelial cells. Oncogene 22:2680–2688

    Article  PubMed  CAS  Google Scholar 

  • Maeda N, Kawada N, Seki S et al (2003) Stimulation of proliferation of rat hepatic stellate cells by galectin-1 and galectin-3 through different intracellular signaling pathways. J Biol Chem 278:18938–18944

    Article  PubMed  CAS  Google Scholar 

  • Mahanthappa NK, Cooper DN, Barondes SH, Schwarting GA (1994) Rat olfactory neurons can utilize the endogenous lectin, L-14, in a novel adhesion mechanism. Development 120:1373–1384

    PubMed  CAS  Google Scholar 

  • Malik RKG, Ghurye RR, Lawrence-Watt DJ, Stewart HJS (2009) Galectin-1 stimulates monocyte chemotaxis via the p44/42 MAP kinase pathway and a pertussis toxin-sensitive pathway. Glycobiology 19:1402–1407

    Article  PubMed  CAS  Google Scholar 

  • Maquoi E, van den Brule FA, Castronovo V, Foidart JM (1997) Changes in the distribution pattern of galectin-1 and galectin-3 in human placenta correlates with the differentiation pathways of trophoblasts. Placenta 18:433–439

    Article  PubMed  CAS  Google Scholar 

  • Marcon P, Marsich E, Vetere A et al (2005) The role of Galectin-1 in the interaction between chondrocytes and a lactose-modified chitosan. Biomaterials 26:4975–4984

    Article  PubMed  CAS  Google Scholar 

  • Marschal P, Herrmann J et al (1992) Sequence and specificity of a soluble lactose-binding lectin from Xenopus laevis skin. J Biol Chem 267:12942–12949

    PubMed  CAS  Google Scholar 

  • Martinez VG, Pellizzari EH et al (2004) Galectin-1, a cell adhesion modulator, induces apoptosis of rat Leydig cells in vitro. Glycobiology 14:127–137

    Article  PubMed  CAS  Google Scholar 

  • Massa SM, Cooper DN et al (1993) L-29, an endogenous lectin, binds to glycoconjugate ligands with positive cooperativity. Biochemistry 32:260–267

    Article  PubMed  CAS  Google Scholar 

  • Matarrese P, Tinari A, Mormone E et al (2005) Galectin-1 sensitizes resting human T lymphocytes to Fas (CD95)-mediated cell death via mitochondrial hyperpolarization, budding, and fission. J Biol Chem 280:6969–6985

    Article  PubMed  CAS  Google Scholar 

  • McGraw J, McPhail LT, Oschipok LW et al (2004a) Galectin-1 in regenerating motoneurons. Eur J Neurosci 20:2872–2880

    Article  PubMed  CAS  Google Scholar 

  • McGraw J, Oschipok LW, Liu J et al (2004b) Galectin-1 expression correlates with the regenerative potential of rubrospinal and spinal motoneurons. Neuroscience 128:713–719

    Article  PubMed  CAS  Google Scholar 

  • McGraw J, Gaudet AD et al (2005) Altered primary afferent anatomy and reduced thermal sensitivity in mice lacking galectin-1. Pain 114:7–18

    Article  PubMed  CAS  Google Scholar 

  • Meynier C, Feracci M, Espeli M et al (2009) NMR and MD investigations of human galectin-1/oligosaccharide complexes. Biophys J 97:3168–3177

    Article  PubMed  CAS  Google Scholar 

  • Miura T, Takahashi M, Horie H et al (2004) Galectin-1β, a natural monomeric form of galectin-1 lacking its six amino-terminal residues promotes axonal regeneration but not cell death. Cell Death Differ 11:1076–1083

    Article  PubMed  CAS  Google Scholar 

  • Miura T, Ohnishi Y et al (2005) Regulation of the neuronal fate by DeltaFosB and its downstream target, galectin-1. Curr Drug Targets 6:437–444

    Article  PubMed  CAS  Google Scholar 

  • Moiseeva EP, Javed Q, Spring EL, de Bono DP (2000) Galectin 1 is involved in vascular smooth muscle cell proliferation. Cardiovasc Res 45:493–502

    Article  PubMed  CAS  Google Scholar 

  • Moiseeva EP, Spring EL, Baron JH et al (1999) Galectin 1 modulates attachment, spreading and migration of cultured vascular smooth muscle cells via interactions with cellular receptors and components of extracellular matrix. J Vasc Res 36:47–58

    Article  PubMed  CAS  Google Scholar 

  • Moiseeva EP, Williams B, Goodall AH et al (2003) Galectin-1 interacts with β-1 subunit of integrin. Biochem Biophys Res Commun 310:1010–1016

    Article  PubMed  CAS  Google Scholar 

  • Morris S, Ahmad N, Andre S et al (2004) Quaternary solution structures of galectins-1, -3, and -7. Glycobiology 14:293–300

    Article  PubMed  CAS  Google Scholar 

  • Nagy N, Legendre H, Engels O et al (2003) Refined prognostic evaluation in colon carcinoma using immunohistochemical galectin fingerprinting. Cancer 97:1849–1858

    Article  PubMed  Google Scholar 

  • Nguyen JT, Evans DP, Galvan M et al (2001) CD45 modulates galectin-1-induced T cell death: regulation by expression of core 2 O-glycans. J Immunol 167:5697–5707

    PubMed  CAS  Google Scholar 

  • Nickel W (2005) Unconventional secretory routes: direct protein export across the plasma membrane of mammalian cells. Traffic 6:607–614

    Article  PubMed  CAS  Google Scholar 

  • Nieminen J, Kuno A, Hirabayashi J, Sato S (2007) Visualization of galectin-3 oligomerization on the surface of neutrophils and endothelial cells using fluorescence resonance energy transfer. J Biol Chem 282:1374–1383

    Article  PubMed  CAS  Google Scholar 

  • Nishioka T, Sakumi K, Miura T et al (2002) FosB gene products trigger cell proliferation and morphological alteration with an increased expression of a novel processed form of galectin-1 in the rat 3Y1embryo cell line. J Biochem 131:653–661

    Article  PubMed  CAS  Google Scholar 

  • Ohannesian DW, Lotan D, Lotan R (1994) Concomitant increases in galectin-1 and its glycoconjugate ligands (carcinoembryonic antigen, lamp-1, and lamp-2) in cultured human colon carcinoma cells by sodium butyrate. Cancer Res 54:5992–6000

    PubMed  CAS  Google Scholar 

  • Okada T, Ichikawa M, Tokita Y et al (2005) Intravitreal macrophage activation enables cat retinal ganglion cells to regenerate injured axons into the mature optic nerve. Exp Neurol 196:153–163

    Article  PubMed  Google Scholar 

  • Ouellet M, Mercier S, Pelletier I et al (2005) Galectin-1 acts as a soluble host factor that promotes HIV-1 infectivity through stabilization of virus attachment to host cells. J Immunol 174:4120–4126

    PubMed  CAS  Google Scholar 

  • Outenreath RL, Jones AL (1992) Influence of an endogenous lectin substrate on cultured dorsal root ganglion cells. J Neurocytol 21:788–795

    Article  PubMed  CAS  Google Scholar 

  • Ozaki K, Inoue K, Sato H et al (2004) Functional variation in LGALS2 confers risk of myocardial infarction and regulates lymphotoxin-alpha secretion in vitro. Nature 429:72–75

    Article  PubMed  CAS  Google Scholar 

  • Ozeki Y, Matsui T, Yamamoto Y et al (1995) Tissue fibronectin is an endogenous ligand for galectin-1. Glycobiology 5:255–261

    Article  PubMed  CAS  Google Scholar 

  • Pace KE, Lee C, Stewart PL, Baum LG (1999) Restricted receptor segregation into membrane microdomains occurs on human T cells during apoptosis induced by galectin-1. J Immunol 163:3801–3811

    PubMed  CAS  Google Scholar 

  • Pace KE, Hahn HP, Pang M et al (2000) CD7 delivers a pro-apoptotic signal during galectin-1-induced T cell death. J Immunol 165:2331–2334

    PubMed  CAS  Google Scholar 

  • Pacienza N, Pozner RG et al (2008) The immunoregulatory glycan-binding protein galectin-1 triggers human platelet activation. FASEB J 22:1113–1123

    Article  PubMed  CAS  Google Scholar 

  • Park JW, Voss PG, Grabski S et al (2001) Association of galectin-1 and galectin-3 with Gemin4 in complexes containing the SMN protein. Nucleic Acids Res 29:3595–3602

    Article  PubMed  CAS  Google Scholar 

  • Paz A, Haklai R, Elad-Sfadia G, Ballan E, Kloog Y (2001) Galectin-1 binds oncogenic H-Ras to mediate Ras membrane anchorage and cell transformation. Oncogene 20:7486–7493

    Article  PubMed  CAS  Google Scholar 

  • Perillo NL, Pace KE, Seilhamer J, Baum LG (1995) Apoptosis of T cells mediated by galectin-1. Nature 378:736–739

    Article  PubMed  CAS  Google Scholar 

  • Perillo NL, Uittenbogaart CH, Nguyen JT et al (1997) Galectin-1, an endogenous lectin produced by thymic epithelial cells, induces apoptosis of human thymocytes. J Exp Med 185:1851–1858

    Article  PubMed  CAS  Google Scholar 

  • Perillo NL, Marcus ME, Baum LG (1998) Galectins: versatile modulators of cell adhesion, cell proliferation, and cell death. J Mol Med 76:402–412

    Article  PubMed  CAS  Google Scholar 

  • Perone MJ, Larregina AT, Shufesky WJ et al (2006) Transgenic galectin-1 induces maturation of dendritic cells that elicit contrasting responses in naive and activated T cells. J Immunol 176:7207–7220

    PubMed  CAS  Google Scholar 

  • Plachta N, Annaheim C, Bissière S et al (2007) Identification of a lectin causing the degeneration of neuronal processes using engineered embryonic stem cells. Nat Neurosci 10:712–719

    Article  PubMed  CAS  Google Scholar 

  • Poirier F, Bourin P, Bladier D et al (2001a) Effect of 5-azacytidine and galectin-1 on growth and differentiation of the human B lymphoma cell line Bl36. Cancer Cell Int 1:2

    Article  PubMed  Google Scholar 

  • Poirier F, Pontet M, Labas V et al (2001b) Two-dimensional database of a Burkitt lymphoma cell line (DG 75) proteins: protein pattern changes following treatment with 5′-azycytidine. Electrophoresis 22:1867–1877

    Article  PubMed  CAS  Google Scholar 

  • Prior IA, Muncke C, Parton RG et al (2003) Direct visualization of Ras proteins in spatially distinct cell surface microdomains. J Cell Biol 160:165–170

    Article  PubMed  CAS  Google Scholar 

  • Puche AC, Poirier F, Hair M et al (1996) Role of galectin-1 in the developing mouse olfactory system. Dev Biol 179:274–287

    Article  PubMed  CAS  Google Scholar 

  • Purkrábková T, Smetana K Jr, Dvoránková B et al (2003) New aspects of galectin functionality in nuclei of cultured bone marrow stromal and epidermal cells: biotinylated galectins as tool to detect specific binding sites. Biol Cell 95:535–545

    Article  PubMed  CAS  Google Scholar 

  • Rabinovich GA (2005) Galectin-1 as a potential cancer target. Br J Cancer 92:1188–1192

    Article  PubMed  CAS  Google Scholar 

  • Rabinovich GA, Gruppi A (2005) Galectins as immunoregulators during infectious processes: from microbial invasion to the resolution of the disease. Parasite Immunol 27:103–114

    Article  PubMed  CAS  Google Scholar 

  • Rabinovich GA, Ariel A, Hershkoviz R et al (1999) Specific inhibition of T-cell adhesion to extracellular matrix and proinflammatory cytokine secretion by human recombinant galectin-1. Immunology 97:100–106

    Article  PubMed  CAS  Google Scholar 

  • Rabinovich GA, Alonso CR, Sotomayor CE et al (2000) Molecular mechanisms implicated in galectin-1-induced apoptosis: activation of the AP-1 transcription factor and downregulation of Bcl-2. Cell Death Differ 7:747–753

    Article  PubMed  CAS  Google Scholar 

  • Rabinovich GA, Ramhorst RE, Rubinstein N et al (2002a) Induction of allogenic T-cell hyporesponsiveness by galectin-1-mediated apoptotic and non-apoptotic mechanisms. Cell Death Differ 9:661–670

    Article  PubMed  CAS  Google Scholar 

  • Rabinovich GA, Rubinstein N, Matar P et al (2002b) The antimetastatic effect of a single low dose of cyclophosphamide involves modulation of galectin-1 and Bcl-2 expression. Cancer Immunol Immunother 50:597–603

    Article  PubMed  CAS  Google Scholar 

  • Rabinovich GA, Sotomayor CE, Riera CM, Bianco I, Correa SG (2000) Evidence of a role for galectin-1 in acute inflammation. Eur J Immunol 30:1331–1339

    Article  PubMed  CAS  Google Scholar 

  • Rabinovich GA, Toscano MA, Ilarregui JM, Rubinstein N (2004) Shedding light on the immunomodulatory properties of galectins: novel regulators of innate and adaptive immune responses. Glycoconj J 19:565–573

    Article  PubMed  Google Scholar 

  • Rochard P, Galiegue S, Tinel N et al (2004) Expression of the peripheral benzodiazepine receptor triggers thymocyte differentiation. Gene Expr 12:13–27

    Article  PubMed  CAS  Google Scholar 

  • Rorive S, Belot N, Decaestecker C et al (2001) Galectin-1 is highly expressed in human gliomas with relevance for modulation of invasion of tumor astrocytes into the brain parenchyma. Glia 33:241–255

    Article  PubMed  CAS  Google Scholar 

  • Rossi B, Espeli M, Schiff C, Gauthier L (2006) Clustering of pre-B cell integrins induces galectin-1-dependent pre-B cell receptor relocalization and activation. J Immunol 177:796–803

    PubMed  CAS  Google Scholar 

  • Rotblat B, Niv H, Andre S et al (2004) Galectin-1(L11A) predicted from a computed galectin-1 farnesyl-binding pocket selectively inhibits Ras-GTP. Cancer Res 64:3112–3118

    Article  PubMed  CAS  Google Scholar 

  • Rubinstein N, Alvarez M, Zwirner NW et al (2004a) Targeted inhibition of galectin-1 gene expression in tumor cells results in heightened T cell-mediated rejection; a potential mechanism of tumor-immune privilege. Cancer Cell 5:241–251

    Article  PubMed  CAS  Google Scholar 

  • Rubinstein N, Ilarregui JM, Toscano MA et al (2004b) The role of galectins in the initiation, amplification and resolution of the inflammatory response. Tissue Antigens 64:1–12

    Article  PubMed  CAS  Google Scholar 

  • Sakaguchi M, Shingo T, Shimazaki T et al (2006) A carbohydrate-binding protein, galectin-1, promotes proliferation of adult neural stem cells. Proc Natl Acad Sci USA 103:7112–7117

    Article  PubMed  CAS  Google Scholar 

  • Salvatore P, Benvenuto G, Pero R et al (2000) Galectin-1 gene expression and methylation state in human T leukemia cell lines. Int J Oncol 17:1015–1018

    PubMed  CAS  Google Scholar 

  • Sangeetha SR, Appukuttan PS (2005) IgA1 is the premier serum glycoprotein recognized by human galectin-1 since T antigen (Galβ1–>3GalNAc-) is far superior to non-repeating N-acetyl lactosamine as ligand. Int J Biol Macromol 35:269–276

    Article  PubMed  CAS  Google Scholar 

  • Sango K, Tokashiki A, Ajiki K et al (2004) Synthesis, localization and externalization of galectin-1 in mature dorsal root ganglion neurons and Schwann cells. Eur J Neurosci 19:55–64

    Article  PubMed  Google Scholar 

  • Sano H, Hsu DK, Yu L et al (2000) Human galectin-3 is a novel chemoattractant for monocytes and macrophages. J Immunol 165:2156–2164

    PubMed  CAS  Google Scholar 

  • Santucci L, Fiorucci S, Cammilleri F et al (2000) Galectin-1 exerts immunomodulatory and protective effects on concanavalin A-induced hepatitis in mice. Hepatology 31:399–406

    Article  PubMed  CAS  Google Scholar 

  • Santucci L, Fiorucci S, Rubinstein N et al (2003) Galectin-1 suppresses experimental colitis in mice. Gastroenterology 124:1381–1394

    Article  PubMed  CAS  Google Scholar 

  • Sarafian V, Jans R, Poumay Y (2006) Expression of lysosome-associated membrane protein 1 (lamp-1) and galectins in humankeratinocytes is regulated by differentiation. Arch Dermatol Res 298:73–81

    Article  PubMed  CAS  Google Scholar 

  • Sasaki T, Hirabayashi J, Manya H, Kasai K, Endo T (2004) Galectin-1 induces astrocyte differentiation, which leads to production of brain-derived neurotrophic factor. Glycobiology 14:357–363

    Article  PubMed  CAS  Google Scholar 

  • Saussez S, Nonclercq D, Laurent G et al (2005) Toward functional glycomics by localization of tissue lectins: immunohistochemical galectin fingerprinting during diethylstilbestrol-induced kidney tumorigenesis in male Syrian hamster. Histochem Cell Biol 123:29–41

    Article  PubMed  CAS  Google Scholar 

  • Saussez S, Cucu DR, Deacestecker C et al (2006) Galectin-7 (p53-induced gene-1): a new prognostic predictor of recurrence and survival in stage IV hypopharyngeal cancer. Ann Surg Oncol 13:999–1009

    Article  PubMed  Google Scholar 

  • Schwarz G Jr, Remmelink M, Decaestecker C et al (1999) Galectin fingerprinting in tumor diagnosis. Differential expression of galectin-3 and galectin-3 binding sites, but not galectin-1, in benign vs malignant uterine smooth muscle tumors. Am J Clin Pathol 111:623–631

    PubMed  Google Scholar 

  • Seelenmeyer C, Wegehingel S, Lechner J, Nickel W (2003) The cancer antigen CA125 represents a novel counter receptor for galectin-1. J Cell Sci 116:1305–1318

    Article  PubMed  CAS  Google Scholar 

  • Seelenmeyer C, Wegehingel S, Tews I et al (2005) Cell surface counter receptors are essential components of the unconventional export machinery of galectin-1. J Cell Biol 171:373–381

    Article  PubMed  CAS  Google Scholar 

  • Shaffer AL, Lin KI, Kuo TC et al (2002) Blimp-1 orchestrates plasma cell differentiation by extinguishing the mature B cell gene expression program. Immunity 17:51–62

    Article  PubMed  CAS  Google Scholar 

  • Shahwan M, Al-Qirim MT et al (2004) Physicochemical properties and amino acid sequence of sheep brain galectin-1. Biochemistry (Mosc) 69:506–512

    Article  CAS  Google Scholar 

  • Shamsul Ola M, Tabish M, Khan FH, Banu N (2007) Purification and some properties of galectin-1 derived from water buffalo (Bubalus bubalis) brain. Cell Biol Int 31:578–585

    Article  PubMed  CAS  Google Scholar 

  • Shapiro-Shelef M, Lin KI, McHeyzer-Williams LJ et al (2003) Blimp-1 is required for the formation of immunoglobulin secreting plasma cells and pre-plasma memory B cells. Immunity 19:607–620

    Article  PubMed  CAS  Google Scholar 

  • Shen J, Person MD, Zhu J et al (2004) Protein expression profiles in pancreatic adenocarcinoma compared with normal pancreatic tissue and tissue affected by pancreatitis as detected by two-dimensional gel electrophoresis and mass spectrometry. Cancer Res 64:9018–9026

    Article  PubMed  CAS  Google Scholar 

  • Shimonishi T, Miyazaki K, Kono N et al (2001) Expression of endogenous galectin-1 and galectin-3 in intrahepatic cholangiocarcinoma. Hum Pathol 32:302–310

    Article  PubMed  CAS  Google Scholar 

  • Shoji H, Deltour L, Nakamura T et al (2009) Expression pattern and role of galectin-1 during early mouse myogenesis. Dev Growth Differ 51:607–615

    Article  PubMed  CAS  Google Scholar 

  • Silva WA Jr, Covas DT, Panepucci RA et al (2003) The profile of gene expression of human marrow mesenchymal stem cells. Stem Cells 21:661–669

    Article  PubMed  CAS  Google Scholar 

  • Simon P, Decaestecker C, Choufani G et al (2001) The levels of retinoid RARβ receptors correlate with galectin-1, -3 and -8 expression in human cholesteatomas. Hear Res 156:1–9

    Article  PubMed  CAS  Google Scholar 

  • Sorme P, Kahl-Knutsson B et al (2003) Design and synthesis of galectin inhibitors. Methods Enzymol 363:157–169

    Article  PubMed  Google Scholar 

  • Stillman BN, Hsu DK, Pang M et al (2006) Galectin-3 and galectin-1 bind distinct cell surface glycoprotein receptors to induce T cell death. J Immunol 176:778–789

    PubMed  CAS  Google Scholar 

  • Stowell SR, Dias-Baruffi M, Penttila L et al (2004) Human galectin-1 recognition of poly-N-acetyllactosamine and chimeric polysaccharides. Glycobiology 14:157–167

    Article  PubMed  CAS  Google Scholar 

  • Stowell SR, Karmakar S, Stowell CJ et al (2007) Human galectin-1, -2, and -4 induce surface exposure of phosphatidylserine in activated human neutrophils but not in activated T cells. Blood 109:219–227

    Article  PubMed  CAS  Google Scholar 

  • Stowell SR, Arthur CM, Mehta P et al (2008a) Galectin-1, -2, and -3 exhibit differential recognition of sialylated glycans and blood group antigens. J Biol Chem 283:10109–10123

    Article  PubMed  CAS  Google Scholar 

  • Stowell SR, Qian Y, Karmakar S et al (2008b) Differential roles of galectin-1 and galectin-3 in regulating leukocyte viability and cytokine secretion. J Immunol 180:3091–3102

    PubMed  CAS  Google Scholar 

  • Stowell SR, Cho M, Feasley CL et al (2009) Ligand reduces galectin-1 sensitivity to oxidative inactivation by enhancing dimer formation. J Biol Chem 284:4989–4999

    Article  PubMed  CAS  Google Scholar 

  • Sturm A, Lensch M, André S et al (2004) Human galectin-2: novel inducer of T cell apoptosis with distinct profile of caspase activation. J Immunol 173:3825–3837

    PubMed  CAS  Google Scholar 

  • Svensson A, Tågerud S (2009) Galectin-1 expression in innervated and denervated skeletal muscle. Cell Mol Biol Lett 14:128–138

    Article  PubMed  CAS  Google Scholar 

  • Symons A, Cooper DN, Barclay AN (2000) Characterization of the interaction between galectin-1 and lymphocyte glycoproteins CD45 and Thy-1. Glycobiology 10:559–563

    Article  PubMed  CAS  Google Scholar 

  • Szoke T, Kayser K et al (2005) Prognostic significance of endogenous adhesion/growth-regulatory lectins in lung cancer. Oncology 69:167–174

    Article  PubMed  CAS  Google Scholar 

  • Tabrizi SJ, Niiro H, Masui M et al (2009) T cell leukemia/lymphoma 1 and galectin-1 regulate survival/cell death pathways in human naive and IgM+ memory B cells through altering balances in Bcl-2 family proteins. J Immunol 182:1490–1499

    PubMed  CAS  Google Scholar 

  • Tahara K, Tsuchimoto D, Tominaga Y et al (2003) DeltaFosB, but not FosB, induces delayed apoptosis independent of cell proliferation in the Rat1a embryo cell line. Cell Death Differ 10:496–507

    Article  PubMed  CAS  Google Scholar 

  • Tenne-Brown J, Puche AC, Key B (1998) Expression of galectin-1 in the mouse olfactory system. Int J Dev Biol 42:791–799

    PubMed  CAS  Google Scholar 

  • Than NG, Kim SS, Abbas A et al (2008a) Chorioamnionitis and increased galectin-1 expression in PPROM – an anti-inflammatory response in the fetal membranes? Am J Reprod Immunol 60:298–311

    Article  PubMed  Google Scholar 

  • Than NG, Romero R, Erez O et al (2008b) Emergence of hormonal and redox regulation of galectin-1 in placental mammals: implication in maternal-fetal immune tolerance. Proc Natl Acad Sci USA 105:15819–15824

    Article  PubMed  CAS  Google Scholar 

  • Thijssen VL, Postel R, Brandwijk RJ et al (2006) Galectin-1 is essential in tumor angiogenesis and is a target for antiangiogenesis therapy. Proc Natl Acad Sci USA 103:15975–15980

    Article  PubMed  CAS  Google Scholar 

  • Timmons PM, Rigby PW, Poirier F (2002) The murine seminiferous epithelial cycle is pre-figured in the Sertoli cells of the embryonic testis. Development 129:635–647

    PubMed  CAS  Google Scholar 

  • Tinari N, Kuwabara I, Huflejt ME et al (2001) Glycoprotein, 90K/MAC-2BP interacts with galectin-1 and mediates galectin-1-induced cell aggregation. Int J Cancer 91:167–172

    Article  PubMed  CAS  Google Scholar 

  • Toscano MA, Bianco GA, Ilarregui JM et al (2007) Differential glycosylation of TH1, TH2 and TH-17 effector cells selectively regulates susceptibility to cell death. Nat Immunol 8:825–834

    Article  PubMed  CAS  Google Scholar 

  • Tsai C-M, Chiu Y-K, Hsu T-L et al (2008) Galectin-1 promotes immunoglobulin production during plasma cell differentiation. J Immunol 181:4570–4579

    PubMed  CAS  Google Scholar 

  • Tsutsumi T, Suzuki T, Moriya K et al (2003) Hepatitis C virus core protein activates ERK and p38 MAPK in cooperation with ethanol in transgenic mice. Hepatology 38:820–828

    PubMed  CAS  Google Scholar 

  • Valkova N, Yunis R, Mak SK et al (2005) Nek8 mutation causes over-expression of galectin-1, sorcin, and vimentin and accumulation of the major urinary protein in renal cysts of jck mice. Mol Cell Proteomics 4:1009–1018

    Article  PubMed  CAS  Google Scholar 

  • van den Brule F, Califice S, Garnier F et al (2003) Galectin-1 accumulation in the ovary carcinoma peritumoral stroma is induced by ovary carcinoma cells and affects both cancer cell proliferation and adhesion to laminin-1 and fibronectin. Lab Invest 83:377–386

    PubMed  Google Scholar 

  • van der Leij J, van den Berg A, Blokzijl T et al (2004) Dimeric galectin-1 induces IL-10 production in T-lymphocytes: an important tool in the regulation of the immune response. J Pathol 204:511–518

    Article  PubMed  CAS  Google Scholar 

  • Vas V, Fajka-Boja R, Ion G et al (2005) Biphasic effect of recombinant galectin-1 on the growth and death of early hematopoietic cells. Stem Cells 23:279–287

    Article  PubMed  CAS  Google Scholar 

  • Vasta GR, Ahmed H, Odom EW (2004) Structural and functional diversity of lectin repertoires in invertebrates, protochordates and ectothermic vertebrates. Curr Opin Struct Biol 14:617–630

    Article  PubMed  CAS  Google Scholar 

  • Vespa GN, Lewis LA, Kozak KR et al (1999) Galectin-1 specifically modulates TCR signals to enhance TCR apoptosis but inhibit IL-2 production and proliferation. J Immunol 162:799–806

    PubMed  CAS  Google Scholar 

  • Vicovac L, Jankovic M, Cuperlovic M (1998) Galectin-1 and -3 in cells of the first trimester placental bed. Hum Reprod 13:730–735

    Article  PubMed  CAS  Google Scholar 

  • von Wolff M, Wang X, Gabius HJ, Strowitzki T (2005) Galectin fingerprinting in human endometrium and decidua during the menstrual cycle and in early gestation. Mol Hum Reprod 11:189–194

    Article  CAS  Google Scholar 

  • Vyakarnam A, Dagher SF, Wang JL et al (1997) Evidence for a role for galectin-1 in pre-mRNA splicing. Mol Cell Biol 17:4730–4737

    PubMed  CAS  Google Scholar 

  • Walzel H, Schulz U et al (1999) Galectin-1, a natural ligand for the receptor-type protein tyrosine phosphatase CD45. Immunol Lett 67:193–202

    Article  PubMed  CAS  Google Scholar 

  • Walzel H, Blach M et al (2000) Involvement of CD2 and CD3 in galectin-1 induced signaling in human Jurkat T-cells. Glycobiology 10:131–140

    Article  PubMed  CAS  Google Scholar 

  • Walzel H, Blach M, Hirabayashi J et al (2002) Galectin-induced activation of the transcription factors NFAT and AP-1 in human Jurkat T-lymphocytes. Cell Signal 14:861–868

    Article  PubMed  CAS  Google Scholar 

  • Walzel H, Brock J, Pohland R et al (2004) Effects of galectin-1 on regulation of progesterone production in granulose cells from pig ovaries in vitro. Glycobiology 14:871–881

    Article  PubMed  CAS  Google Scholar 

  • Walzel H, Fahmi AA, Eldesouky MA et al (2006) Effects of N-glycan processing inhibitors on signaling events and induction of apoptosis in galectin-1-stimulated Jurkat T lymphocytes. Glycobiology 16:1262–1271

    Article  PubMed  CAS  Google Scholar 

  • Wang P, Mariman E, Keijer J et al (2004) Profiling of the secreted proteins during 3 T3-L1 adipocyte differentiation leads to the identification of novel adipokines. Cell Mol Life Sci 61:2405–2417

    PubMed  CAS  Google Scholar 

  • Wang J, Lu ZH, Gabius HJ et al (2009) Cross-linking of GM1 ganglioside by galectin-1 mediates regulatory T cell activity involving TRPC5 channel activation: possible role in suppressing experimental autoimmune encephalomyelitis. J Immunol 182:4036–4045

    Article  PubMed  CAS  Google Scholar 

  • Wasano K, Hirakawa Y (1997) Recombinant galectin-1 recognizes mucin and epithelial cell surface glycocalyces of gastrointestinal tract. J Histochem Cytochem 45:275–283

    Article  PubMed  CAS  Google Scholar 

  • Wells V, Davies D, Mallucci L (1997) Cell cycle arrest and induction of apoptosis by β galactoside binding protein (β GBP) in human mammary cancer cells. A potential new approach to cancer control. Eur J Cancer 35:978–983

    Article  Google Scholar 

  • Wiest I, Seliger C et al (2005) Induction of apoptosis in human breast cancer and trophoblast tumor cells by galectin-1. Anticancer Res 25:1575–1580

    PubMed  CAS  Google Scholar 

  • Woynarowska B, Skrincosky DM et al (1994) Inhibition of lectin-mediated ovarian tumor cell adhesion by sugar analogs. J Biol Chem 269:22797–22803

    PubMed  CAS  Google Scholar 

  • Xu Z, Weiss A (2002) Negative regulation of CD45 by differential homodimerization of the alternatively spliced isoforms. Nat Immunol 3:764–771

    Article  PubMed  CAS  Google Scholar 

  • Yamaoka K, Mishima K, Nagashima Y et al (2000) Expression of galectin-1 mRNA correlates with the malignant potential of human gliomas and expression of antisense galectin-1 inhibits the growth of 9 glioma cells. J Neurosci Res 59:722–730

    Article  PubMed  CAS  Google Scholar 

  • Yang JW, Kang SU et al (2006) Mass spectrometrical analysis of galectin proteins in primary rat cerebellar astrocytes. Neurochem Res 31:945–955

    Article  PubMed  CAS  Google Scholar 

  • Yu X, Siegel R, Roeder RG (2006) Interaction of the B cell-specific transcriptional coactivator OCA-B and galectin-1 and a possible role in regulating BCR-mediated B cell proliferation. J Biol Chem 281:15505–15516

    Article  PubMed  CAS  Google Scholar 

  • ZacarÃas Fluck MF, Rico MJ et al (2007) Low-dose cyclophosphamide modulates galectin-1 expression and function in an experimental rat lymphoma model. Cancer Immunol Immunother 56:237–248

    Article  CAS  Google Scholar 

  • Zhao XY, Zhao KW, Jiang Y et al (2011) Synergistic induction of galectin-1 by C/EBPα and HIF-1α and its role in differentiation of acute myeloid leukemic cells. J Biol Chem 286(42):36808–36819, Aug 31

    Article  PubMed  CAS  Google Scholar 

  • Zou W (2005) Immunosuppressive networks in the tumour environment and their therapeutic relevance. Nat Rev Cancer 5:263–274

    Article  PubMed  CAS  Google Scholar 

  • Zuniga E, Rabinovich GA, Iglesias MM, Gruppi A (2001) Regulated expression of galectin-1 during B-cell activation and implications for T-cell apoptosis. J Leukoc Biol 70:73–79

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Biomedical Engineering, Rayat and Bahra Institute of Engineering and Biotechnology, Kharar (Mohali), Punjab, India

    Anita Gupta (Assistant Professor)

Authors
  1. Anita Gupta
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

Copyright information

© 2012 Springer-Verlag Wien

About this chapter

Cite this chapter

Gupta, A. (2012). Galectin-1: Forms and Functions. In: Animal Lectins: Form, Function and Clinical Applications. Springer, Vienna. https://doi.org/10.1007/978-3-7091-1065-2_10

Download citation

Publish with us

Policies and ethics

Search

Navigation