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Store-operated Ca2+ entry (SOCE) pathways pp 45–56Cite as

The STIM-Orai Pathway

The Interactions Between STIM1 and Orai

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Abstract

A primary Ca2+ entry pathway in non-excitable cells is determined by the Ca2+ release activated Ca2+ channels. Their two limiting molecular components include the Ca2+-sensor protein STIM1 located in the endoplasmic reticulum and the Orai channel in the plasma membrane. STIM1 senses the luminal Ca2+ content. Store depletion induces STIM1 oligomerization into puncta like structures, thereby triggering coupling to as well as activation of Orai1 channels. A C-terminal STIM1 domain couples to both N- and C-terminal, cytosolic strands of Orai, accomplishing gating of the channel. Here we highlight the inter- and intramolecular choreography of STIM1 and Orai proteins that govern in Ca2+ permeation.

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Authors and Affiliations

  1. Institute of Biophysics, University of Linz, Linz, Austria

    Rainer Schindl, Marc Fahrner, Martin Muik & Christoph Romanin

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  1. Rainer Schindl
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  2. Marc Fahrner
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  3. Martin Muik
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  4. Christoph Romanin
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Corresponding authors

Correspondence to Rainer Schindl or Christoph Romanin .

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Editors and Affiliations

  1. Center for Physiological Medicine, Medical University of Graz, Harrachgasse 21/IV, Graz, 8010, Austria

    Klaus Groschner

  2. , Center for Molecular Medicine, Medical University of Graz, Harrachgasse 21/III, Graz, 8010, Austria

    Wolfgang F. Graier

  3. , Institute of Biophysics, University of Linz, Gruberstrasse 40, Linz, 4020, Austria

    Christoph Romanin

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Schindl, R., Fahrner, M., Muik, M., Romanin, C. (2012). The STIM-Orai Pathway. In: Groschner, K., Graier, W., Romanin, C. (eds) Store-operated Ca2+ entry (SOCE) pathways. Springer, Vienna. https://doi.org/10.1007/978-3-7091-0962-5_4

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