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Store-operated Ca2+ entry (SOCE) pathways pp 461–473Cite as

Reproductive System

Store-operated Ca2+ Entry in Germ Cells: Role in Egg Activation

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Abstract

At the time of fertilization the sperm activates the egg and induces embryonic development by triggering an elevation in the egg’s intracellular free Ca2+ concentration. In mammals the initial Ca2+ rise is followed by a series of repetitive Ca2+ transients that lasts for several hours. Although the source of Ca2+ during the signaling process is primarily the egg’s smooth endoplasmic reticulum, the oscillation stops in the absence of extracellular Ca2+ indicating that a Ca2+ influx across the plasma membrane is essential to sustain it. Depletion of the intracellular stores using specific inhibitors generates a Ca2+ entry across the plasma membrane of eggs of various species and a continuous influx of Ca2+ has been linked to the sperm-induced Ca2+ oscillation in the mouse; these data indicate that store-operated Ca2+ entry (SOCE) operates in eggs and may be the mechanism that maintains the long-lasting signal at fertilization. Recent findings suggest that the signaling proteins STIM1 and Orai1 are present in eggs; they are responsible for mediating SOCE, and their functions are essential for proper Ca2+ signaling at fertilization to support normal embryo development.

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Authors and Affiliations

  1. Department of Animal Sciences, Lilly Hall of Life Sciences, Purdue University, West Lafayette, IN, USA

    Zoltan Machaty & Chunmin Wang

  2. Animal Science Research Center, University of Missouri – Columbia, Columbia, MO, USA

    Kiho Lee

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  1. Zoltan Machaty
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  2. Chunmin Wang
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  3. Kiho Lee
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Correspondence to Zoltan Machaty .

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Editors and Affiliations

  1. Center for Physiological Medicine, Medical University of Graz, Harrachgasse 21/IV, Graz, 8010, Austria

    Klaus Groschner

  2. , Center for Molecular Medicine, Medical University of Graz, Harrachgasse 21/III, Graz, 8010, Austria

    Wolfgang F. Graier

  3. , Institute of Biophysics, University of Linz, Gruberstrasse 40, Linz, 4020, Austria

    Christoph Romanin

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© 2012 Springer-Verlag Wien

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Machaty, Z., Wang, C., Lee, K. (2012). Reproductive System. In: Groschner, K., Graier, W., Romanin, C. (eds) Store-operated Ca2+ entry (SOCE) pathways. Springer, Vienna. https://doi.org/10.1007/978-3-7091-0962-5_29

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