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Pathophysiological Perspective of Neuronal Store-operated Ca2+ Signaling

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Book cover Store-operated Ca2+ entry (SOCE) pathways

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Abstract

Calcium (Ca2+), as a ubiquitous second messenger, performs significant physiological tasks in regulating a plethora of neuronal functions including neurosecretion, exocytosis, neuronal growth/differentiation, and the development and maintenance of neural circuits. An important regulatory aspect of neuronal Ca2+ homeostasis is store-operated Ca2+ entry (SOCE), which, in recent years, has gained much attention for influencing a variety of nerve cell responses. Essentially, activation of SOCE ensues following the activation of the plasma membrane (PM) store-operated Ca2+ channels (SOCC) triggered by the depletion of endoplasmic reticulum (ER) Ca2+ stores. In addition to the TRP (Transient receptor potential) family of ion channels, the recently identified Orai and STIM (stromal interacting molecule) proteins have been baptized as key molecular components of SOCE. Functional significance of the TRP channels in neurons has been elaborately studied however, information on Orai and STIM components of SOCE, although seems imminent, is currently limited. Importantly, perturbations in SOCE have been implicated in a spectrum of neuropathological conditions. Hence, understanding the precise involvement of SOCC in neurodegeneration would presumably unveil avenues for plausible therapeutic interventions. We thus review the role of SOCE-regulated neuronal Ca2+ signaling in select neurodegenerative conditions.

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Authors and Affiliations

  1. Department of Biochemistry & Molecular Biology, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND, USA

    Sunitha Bollimuntha, Biswaranjan Pani & Brij B. Singh

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  1. Sunitha Bollimuntha
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  2. Biswaranjan Pani
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  3. Brij B. Singh
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Correspondence to Sunitha Bollimuntha or Brij B. Singh .

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Editors and Affiliations

  1. Center for Physiological Medicine, Medical University of Graz, Harrachgasse 21/IV, Graz, 8010, Austria

    Klaus Groschner

  2. , Center for Molecular Medicine, Medical University of Graz, Harrachgasse 21/III, Graz, 8010, Austria

    Wolfgang F. Graier

  3. , Institute of Biophysics, University of Linz, Gruberstrasse 40, Linz, 4020, Austria

    Christoph Romanin

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Bollimuntha, S., Pani, B., Singh, B.B. (2012). Nervous System. In: Groschner, K., Graier, W., Romanin, C. (eds) Store-operated Ca2+ entry (SOCE) pathways. Springer, Vienna. https://doi.org/10.1007/978-3-7091-0962-5_26

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