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Roles of Neuronal Activity-Induced Gene Products in Hebbian and Homeostatic Synaptic Plasticity, Tagging, and Capture

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Book cover Synaptic Plasticity

Part of the book series: Advances in Experimental Medicine and Biology ((volume 970))

Abstract

The efficiency of synaptic transmission undergoes plastic modification in response to changes in input activity. This phenomenon is most commonly referred to as synaptic plasticity and can involve different cellular mechanisms over time. In the short term, typically in the order of minutes to 1 h, synaptic plasticity is mediated by the actions of locally existing proteins. In the longer term, the synthesis of new proteins from existing or newly synthesized mRNAs is required to maintain the changes in synaptic transmission. Many studies have attempted to identify genes induced by neuronal activity and to elucidate the functions of the encoded proteins. In this chapter, we describe our current understanding of how activity can regulate the synthesis of new proteins, how the distribution of the newly synthesized protein is regulated in relation to the synapses undergoing plasticity and the function of these proteins in both Hebbian and homeostatic synaptic plasticity.

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Acknowledgments

We would like to express our sincere gratitude to collaborators of our works introduced here, especially Drs. Mariko Kato-Hayashi, Carlo Sala, Morgan Sheng, Atsushi Miyawaki, Rui-ming Xu, Huilin Li, Mriganka Sur, and members of their laboratories. We thank Drs. Dan Ohtan Wang and Lily Yu for comments on the manuscript. This work was supported by RIKEN, NIH grant R01DA17310, Grant-in-Aid for Scientific Research (A) and Grant-in-Aid for Scientific Research on Innovative Area “Foundation of Synapse and Neurocircuit Pathology” from the Ministry of Education, Science, and Culture of Japan to YH. MB is a recipient of a Beatriu de Pinós fellowship from the Generalitat de Catalunya.

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Authors and Affiliations

  1. Brain Science Institute, Central Building S506, RIKEN, 2-1 Hirosawa, Wako, Saitama, 351-0198, Japan

    Yasunori Hayashi

  2. Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, ON, M5G 1X5, Canada

    Ken-ichi Okamoto

  3. Department of Brain and Cognitive Sciences, The Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA

    Miquel Bosch

  4. Department of Psychiatry, Brudnick Neuropsychiatric Research Institute, University of Massachusetts Medical School, Worcester, MA, 01604-1676, USA

    Kensuke Futai

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  1. Yasunori Hayashi
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  2. Ken-ichi Okamoto
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  3. Miquel Bosch
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  4. Kensuke Futai
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Correspondence to Yasunori Hayashi .

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  1. , PG Neuroplasticity, Leibniz Institute for Neurobiology, Brenneckestraße 6, Magdeburg, 39118, Germany

    Michael R. Kreutz

  2. , Institute of Neuroscience, CR6 CNR-IN Consiglio Nazionale delle Ric, Via Vanvitelli, 32, Milano, 20129, Italy

    Carlo Sala

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Hayashi, Y., Okamoto, Ki., Bosch, M., Futai, K. (2012). Roles of Neuronal Activity-Induced Gene Products in Hebbian and Homeostatic Synaptic Plasticity, Tagging, and Capture. In: Kreutz, M., Sala, C. (eds) Synaptic Plasticity. Advances in Experimental Medicine and Biology, vol 970. Springer, Vienna. https://doi.org/10.1007/978-3-7091-0932-8_15

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