Abstract
Colpocephaly is an abnormal enlargement of the occipital horns, i.e., the posterior or rear portions of the lateral ventricles of the brain, and is associated with several other brain abnormalities. Colpocephaly is occasionally misdiagnosed as hydrocephalus, and various etiologies have been postulated, including genetic disorders and errors of morphogenesis. Meanwhile, chromosomal losses including 22q and rarely 21q are observed in malignant and atypical meningiomas. We report an uncommon case of a 67-year-old woman with colpocephaly and an atypical meningioma in the posterior fossa. There were no neurological deficits or family history of hereditary neuropsychiatric disorders. Brain magnetic resonance (MR) images showed bilateral enlarged occipital horns, agenesis of corpus callosum, and a cerebellar mass in the right cerebellar hemisphere. Right suboccipital craniotomy was performed, and the tumor was resected totally. Pathological study of the surgical specimen showed findings of atypical meningioma, and the postoperative course was uneventful until hydrocephalus developed. At 36th day after tumor removal, the patient undertook an external ventricular drainage followed by replacement of the ventriculoperitoneal shunt. We discuss the importance of colpocephaly in terms of the differential diagnosis for hydrocephalus and review the pertinent literature.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Bodensteiner J, Gay CT (1990) Colpocephaly: pitfalls in the diagnosis of a pathologic entity utilizing neuroimaging techniques. J Child Neurol 5:166–168
Cerullo A, Marini C, Cevoli S, Carelli V, Ontagna P, Tinuper P (2000) Colpocephaly in two siblings: further evidence of a genetic transmission. Dev Med Child Neurol 42:280–282
Dziuk TW, Woo S, Butler EB, Thornby J, Grossman R, Dennis WS, Lu H, Carpenter LS, Chiu JK (1998) Malignant meningioma: an indication for initial aggressive surgery and adjuvant radiotherapy. J Neurooncol 37:177–188
Ferrie CD, Jackson GD, Giannakodimos S, Panayiotopoulos CP (1995) Posterior agyria-pachygyria with polymicrogyria: evidence for an inherited neuronal migration disorder. Neurology 45:150–153
Gabeau-Lacet D, Engler D, Gupta S, Scangas GA, Betensky RA, Barker FG 2nd, Loeffler JS, Louis DN, Mohapatra G (2009) Genomic profiling of atypical meningiomas associates gain of 1q with poor clinical outcome. J Neuropathol Exp Neurol 68:1155–1165
Goyal LK, Suh JH, Mohan DS, Prayson RA, Lee J, Barnett GH (2000) Local control and overall survival in atypical meningioma: a retrospective study. Int J Radiat Oncol Biol Phys 46:57–61
Guimei Y, Xiao-Ning C, Laura FS, Gillian MB, Giandomenico P, John BM, Barbara M, Richard PM, Julie RK (2006) Deletion of chromosome 21 disturbs human brain morphogenesis. Genet Med 8:1–7
Herskowitz J, Rosman NP, Wheeler CB (1985) Colpocephaly: clinical, radiologic, and pathogenetic aspects. Neurology 35:1594–1598
Landman J, Weitz R, Dulitzki F, Shuper A, Sirota L, Aloni D, Bar-Ziv J, Gadoth N (1989) Radiological colpocephaly: a congenital malformation or the result of intrauterine and perinatal brain damage. Brain Dev 11:313–316
Milker-Zabel S, Zabel A, Schulz-Ertner D, Schlegel W, Wannenmacher M, Debus J (2005) Fractionated stereotactic radiotherapy in patients with benign or atypical intracranial meningioma: long-term experience and prognostic factors. Int J Radiat Oncol Biol Phys 61:809–816
Noorani PA, Bodensteiner JB, Barnes PD (1988) Colpocephaly: frequency and associated findings. J Child Neurol 3:100–104
Palma L, Celli P, Franco C, Cervoni L, Cantore G (1997) Long-term prognosis for atypical and malignant meningiomas: a study of 71 surgical cases. J Neurosurg 86:793–800
Puvabanditsin S, Garrow E, Ostrerov Y, Trucanu D, Ilic M, Cholenkeril JV (2006) Colpocephaly: a case report. Am J Perinatol 23:295–297
Utsunomiya H, Ogasawara T, Hayashi T, Hashimoto T, Okazaki M (1997) Dysgenesis of the corpus callosum and associated telencephalic anomalies: MRI. Neuroradiology 39:302–310
Willis J, Smith C, Ironside JW, Erridge S, Whittle IR, Everington D (2000) The accuracy of meningioma grading: a 10-year retrospective audit. Neuropathol Appl Neurobiol 31:141–149
Zang KD (2001) Meningioma: a cytogenetic model of a complex benign human tumor, including data on 394 karyotyped cases. Cytogenet Cell Genet 93:207–220
Conflicts of interest statement
We declare that we have no conflict of interest.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2012 Springer-Verlag/Wien
About this paper
Cite this paper
Cheong, J.H., Kim, C.H., Yang, M.S., Kim, J.M. (2012). Atypical Meningioma in the Posterior Fossa Associated with Colpocephaly and Agenesis of the Corpus Callosum. In: Aygok, G., Rekate, H. (eds) Hydrocephalus. Acta Neurochirurgica Supplementum, vol 113. Springer, Vienna. https://doi.org/10.1007/978-3-7091-0923-6_33
Download citation
DOI: https://doi.org/10.1007/978-3-7091-0923-6_33
Published:
Publisher Name: Springer, Vienna
Print ISBN: 978-3-7091-0922-9
Online ISBN: 978-3-7091-0923-6
eBook Packages: MedicineMedicine (R0)