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Antitumor Vaccines Based on Synthetic Mucin Glycopeptides

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Anticarbohydrate Antibodies

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Abstract

The interest in tumor-associated glycoconjugate antigens was particularly initiated by Springer, who published in 1984 that glycoproteins on the outer cell-membrane of epithelial tumor cells have an altered glycosylation consisting of the Thomsen-Friedenreich (T-) antigen and its precursor the TN-antigen structure (Springer 1984). He and his coworkers also had found that monoclonal antibodies induced with glycoproteins from tumor cell membranes showed cross-reactivity to desialylated glycophorin A. It was concluded from these observations that the T-and TN-glycoproteins on the epithelial tumor cells must be structurally related to asialoglycophorin A (Springer et al. 1983) (Fig. 11.1a). Glycophorin A is the major sialoglycoprotein on erythrocytes. In the N-terminal domain it contains cryptic T-antigen structures which are covered by sialylation in the 3′- and 6-position. The glycophorin exists in two blood group specificities M and N, which have identical glycoforms, but differ in two of the total 131 amino acids.

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  1. Gesellschaft zur Förderung der Analytischen Wissenschaften e.V, ISAS – Leibniz Institute for Analytical Sciences, Otto-Hahn-Str. 6b, D-44227, Dortmund, Germany

    Ulrika Westerlind

  2. Institut für Organische Chemie, Johannes Gutenberg-Universität Mainz, Duesbergweg 10-14, D-55128, Mainz, Germany

    Horst Kunz

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  1. Ulrika Westerlind
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  1. , Department für Chemie, Universität für Bodenkultur Wien, Muthgasse 18, Wien, 1190, Austria

    Paul Kosma

  2. , Zentrum für Medizin und Biowissenschafte, Forschungszentrum Borstel, Parkallee 22, Borstel, 23845, Germany

    Sven Müller-Loennies

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Westerlind, U., Kunz, H. (2012). Antitumor Vaccines Based on Synthetic Mucin Glycopeptides. In: Kosma, P., Müller-Loennies, S. (eds) Anticarbohydrate Antibodies. Springer, Vienna. https://doi.org/10.1007/978-3-7091-0870-3_11

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