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Bacterial Lipopolysaccharides pp 275–310Cite as

Genetics, Biosynthesis and Assembly of O-Antigen

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Abstract

Lipopolysaccharide (LPS), a major component of the outer leaflet of the Gram-negative bacterial outer membrane [1], consists of lipid A, core oligosaccharide (OS), and O-specific polysaccharide or O-antigen [1,2]. LPS is a surface molecule unique to Gram-negative bacteria that plays a key role as an elicitor of innate immune responses, ranging from localized inflammation to disseminated sepsis [3]. The O-antigen, which is the most surface-exposed LPS moiety, also contributes to pathogenicity by protecting invading bacteria from bactericidal host responses [2]. A detailed understanding of the biosynthesis of the LPS O-antigen may contribute to identifying new means to curtail infections by interfering with its assembly.

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Acknowledgments

Research in the authors’ laboratory has been supported by grants from the Canadian Institutes of Health Research, Natural Sciences and Engineering Research Council, the Mizutani Foundation for Glycoscience, Cystic Fibrosis Canada, Ontario Ministry of Innovation, and the Canadian Foundation for Innovation. S.E.F. and K.B.P. hold Ontario Graduate Science and Technology scholarships. M.A.V. holds a Canada Research Chair in Infectious Diseases and Microbial Pathogenesis.

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Authors and Affiliations

  1. Centre for Human Immunology and Department of Microbiology and Immunology, University of Western Ontario, London, ON, N6A 5C1, Canada

    Miguel A. Valvano, Sarah E. Furlong & Kinnari B. Patel

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  1. Miguel A. Valvano
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  2. Sarah E. Furlong
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  3. Kinnari B. Patel
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Correspondence to Miguel A. Valvano .

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Editors and Affiliations

  1. N.D. Zelinsky Institute of Organic Chemi, Russian Academy of Sciences, Leninsky Prospekt 47, Moscow, V-334, 119991, Russian Federation

    Yuriy A. Knirel

  2. Centre for Human Immunology and, Department of Microbiology and Immunolog, University of Western Ontario, London, N6A 5C1, Ontario, Canada

    Miguel A. Valvano

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© 2011 Springer-Verlag/Wien

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Valvano, M.A., Furlong, S.E., Patel, K.B. (2011). Genetics, Biosynthesis and Assembly of O-Antigen. In: Knirel, Y., Valvano, M. (eds) Bacterial Lipopolysaccharides. Springer, Vienna. https://doi.org/10.1007/978-3-7091-0733-1_9

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