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Pathways for the Biosynthesis of NDP Sugars

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Bacterial Lipopolysaccharides

Abstract

Bacterial lipopolysaccharide (LPS) is an important surface structure of Gramnegative bacteria for maintaining the integrity of the outer membrane. It is also a virulence factor in many bacteria, particularly those that are pathogens of plants and animals. Structurally, the LPS can be divided into three domains, lipid A, core oligosaccharide and O-polysaccharide (or O-antigen). Its polysaccharide constituents contain a great variety of sugars including neutral sugars, charged sugars that are acidic or amino substituted (see Chap. 3). Substitutions and enzymatic modifications of the basic sugar structure also lead to interesting deoxy or dideoxy sugars.

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Notes

  1. 1.

    Numbers in parentheses refer to the corresponding structures depicted in the figures.

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Acknowledgements

Research in the Lam laboratory is supported by operating grants from the Canadian Institute of Health Research (#MOP-14687), and the Canadian Cystic Fibrosis Foundation. J.S.L. holds a Canada Research Chair in Cystic Fibrosis and Microbial Glycobiology jointly funded by the Canadian Foundation of Innovation and the Ontario Research Fund.

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  1. Department of Molecular and Cellular Biology, University of Guelph, 50 Stone Road E., Guelph, Canada, ON, N1G 2W1

    Youai Hao & Joseph S. Lam

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  1. N.D. Zelinsky Institute of Organic Chemi, Russian Academy of Sciences, Leninsky Prospekt 47, Moscow, V-334, 119991, Russian Federation

    Yuriy A. Knirel

  2. Centre for Human Immunology and, Department of Microbiology and Immunolog, University of Western Ontario, London, N6A 5C1, Ontario, Canada

    Miguel A. Valvano

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Hao, Y., Lam, J.S. (2011). Pathways for the Biosynthesis of NDP Sugars. In: Knirel, Y., Valvano, M. (eds) Bacterial Lipopolysaccharides. Springer, Vienna. https://doi.org/10.1007/978-3-7091-0733-1_7

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