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Chemical Synthesis of Lipid A and Analogues

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Bacterial Lipopolysaccharides

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Abstract

Chemical syntheses of lipid A and its analogues have made substantial contributions to our current understanding of the endotoxic active structures by providing homogeneous products with definite structures. Precise information has been obtained from the use of synthetic lipid A derivatives, which exclude the possibility of influence by contaminants from bacterial or other sources. In this chapter, representative synthetic work on lipid A and analogues will be outlined with brief explanations of their significance for endotoxin research.

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Authors and Affiliations

  1. Suntory Institute for Bioorganic Research, Wakayamadai 1-1-1, Shimamoto-cho, Mishima-gun, Osaka, 618–8503, Japan

    Shoichi Kusumoto

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  1. Shoichi Kusumoto
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Correspondence to Shoichi Kusumoto .

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Editors and Affiliations

  1. N.D. Zelinsky Institute of Organic Chemi, Russian Academy of Sciences, Leninsky Prospekt 47, Moscow, V-334, 119991, Russian Federation

    Yuriy A. Knirel

  2. Centre for Human Immunology and, Department of Microbiology and Immunolog, University of Western Ontario, London, N6A 5C1, Ontario, Canada

    Miguel A. Valvano

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Kusumoto, S. (2011). Chemical Synthesis of Lipid A and Analogues. In: Knirel, Y., Valvano, M. (eds) Bacterial Lipopolysaccharides. Springer, Vienna. https://doi.org/10.1007/978-3-7091-0733-1_4

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