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Intracerebral Hemorrhage Research pp 201–206Cite as

Neuroprotection by Melatonin after Germinal Matrix Hemorrhage in Neonatal Rats

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Part of the book series: Acta Neurochirurgica Supplementum ((NEUROCHIRURGICA,volume 111))

Abstract

Background: Germinal matrix hemorrhage (GMH) is a devastating neurological disorder of very low birth weight premature infants that leads to post-hemorrhagic hydrocephalus, cerebral palsy, and mental retardation. Melatonin is a potent antioxidant known to reverse free-radical mediated injury in the brain. This study investigated the effect of melatonin treatment after GMH injury.

Methods: Clostridial collagenase was infused into the right germinal matrix region of neonatal rats with stereotaxic technique. Cognitive function, sensorimotor ability, cerebral, cardiac and splenic growths were measured in juvenile animals.

Results: Systemic melatonin treatment ameliorated cognitive and sensorimotor dysfunction at the juvenile developmental stage. This hormone also normalized brain atrophy, splenomegaly, and cardiac hypertrophy consequences at 1 month after injury.

Conclusion: This study supports the role of free radicals in acute neonatal hemorrhagic brain injury. Melatonin is an effective antioxidant that can protect the infant’s brain from the post-hemorrhagic consequences of mental retardation and cerebral palsy. Further mechanistic studies are warranted to determine the mechanisms behind these neuroprotective effects.

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Conflict of interest statement

We declare that we have no conflict of interest.

Author information

Authors and Affiliations

  1. Department of Physiology, Loma Linda University, School of Medicine, Loma Linda, CA, USA

    Tim Lekic, Anatol Manaenko, William Rolland, Kelly Virbel & Jiping Tang

  2. Department of Psychology, Loma Linda University, School of Medicine, Loma Linda, CA, USA

    Richard Hartman

  3. Department of Anesthesiology, Loma Linda University, School of Medicine, Loma Linda, CA, USA

    John H. Zhang

  4. Department of Neurosurgery, Loma Linda University, School of Medicine, Loma Linda, CA, USA

    John H. Zhang

  5. Department of Physiology, Loma Linda University, School of Medicine, Risley Hall, Room 223, 92354, Loma Linda, CA, USA

    John H. Zhang

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  1. Tim Lekic
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  2. Anatol Manaenko
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  4. Kelly Virbel
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  5. Richard Hartman
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  6. Jiping Tang
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  7. John H. Zhang
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Correspondence to John H. Zhang .

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Editors and Affiliations

  1. , Neurosurgery, Physiology, Loma Linda University, Campus Street 11041, Loma Linda, 92530, USA

    John Zhang

  2. School of Medicine, Dept. Neurosurgery, Loma Linda University, Anderson St. 11234, Loma Linda, 92354, California, USA

    Austin Colohan

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Lekic, T. et al. (2011). Neuroprotection by Melatonin after Germinal Matrix Hemorrhage in Neonatal Rats. In: Zhang, J., Colohan, A. (eds) Intracerebral Hemorrhage Research. Acta Neurochirurgica Supplementum, vol 111. Springer, Vienna. https://doi.org/10.1007/978-3-7091-0693-8_34

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  • DOI: https://doi.org/10.1007/978-3-7091-0693-8_34

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  • Online ISBN: 978-3-7091-0693-8

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