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Multiple System Atrophy pp 83–96Cite as

Animal Models

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Abstract

The malignant course of the disease and its poor prognosis, combined with the lack of effective treatment, challenges researchers to search for therapeutic approaches for MSA. In this respect, animal models are needed to preclinically test possible therapeutic candidates before going into a clinical trial. Furthermore, the lack of knowledge on the pathogenesis of the disease presents another urgent reason for developing relevant animal models that may answer basic questions about the molecular mechanisms, which may then be targeted to prevent disease progression. Since the etiology of MSA is still enigmatic, existing models are based on phenotypic replication in rodents of the main neuropathological features of the human disease. Despite their limitations, the phenotypic models have proven to be a valuable tool for preclinical studies on the pathogenesis and therapeutic options for MSA.

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Author information

Authors and Affiliations

  1. Division of Neurobiology – Laboratory for Neurodegenerative Disease Research, Department of Neurology, Innsbruck Medical University, Anichstrasse 35, Innsbruck, 6020, Austria

    Nadia Stefanova MD, PhD, PD

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  1. Nadia Stefanova MD, PhD, PD
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Correspondence to Nadia Stefanova MD, PhD, PD .

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Editors and Affiliations

  1. Division of Clinical Neurobiology, Innsbruck Medical University, Innsbruck, Austria

    Gregor K. Wenning

  2. Department of Neurology Division of Neurobiology, Innsbruck Medical University, Innsbruck, Austria

    Alessandra Fanciulli

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© 2014 Springer-Verlag Wien

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Stefanova, N. (2014). Animal Models. In: Wenning, G., Fanciulli, A. (eds) Multiple System Atrophy. Springer, Vienna. https://doi.org/10.1007/978-3-7091-0687-7_5

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  • DOI: https://doi.org/10.1007/978-3-7091-0687-7_5

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  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-7091-0686-0

  • Online ISBN: 978-3-7091-0687-7

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