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Mechanisms of Secondary Brain Damage from Trauma and Ischemia pp 37–45Cite as

Genetically modified animals in molecular stroke research

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Part of the book series: Acta Neurochirurgica Supplements ((NEUROCHIRURGICA,volume 89))

Abstract

Brain damage induced by focal interruption of blood flow can be differentiated in two pathophysiologically different categories: a hemodynamic type of injury, resulting in primary necrotic brain damage, and a molecular type of injury which leads to delayed or secondary brain injury [15]. Primary necrotic brain injury occurs when blood flow declines — and remains — below the threshold of energy failure. In anaesthetized laboratory animals, this threshold gradually increases from about 15% of control shortly after the onset of ischemia to about 30% after several hours of vascular occlusion [35].

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  1. Max-Planck-Institute for Neurological Research, Department of Experimental Neurology, Cologne, Germany

    Prof. Dr. K.-A. Hossmann

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  1. Institut für Chirurgische Forschung, Ludwig-Maximilians-Universität München, München, Germany

    A. Baethmann  & N. Plesnila  & 

  2. Neurochirurgische Klinik, Universität Würzburg, Würzburg, Germany

    J. Eriskat

  3. Neurochirurgische Klinik, Universität Freiburg, Freiburg, Germany

    J. Lehmberg

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Hossmann, KA. (2004). Genetically modified animals in molecular stroke research. In: Baethmann, A., Eriskat, J., Lehmberg, J., Plesnila, N. (eds) Mechanisms of Secondary Brain Damage from Trauma and Ischemia. Acta Neurochirurgica Supplements, vol 89. Springer, Vienna. https://doi.org/10.1007/978-3-7091-0603-7_5

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