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Role of mitochondrial proteins for neuronal cell death after focal cerebral ischemia

  • Conference paper
Mechanisms of Secondary Brain Damage from Trauma and Ischemia

Part of the book series: Acta Neurochirurgica Supplements ((NEUROCHIRURGICA,volume 89))

Abstract

Cell death following focal cerebral ischemia has an acute and a delayed component. Delayed neuronal cell death occurs via activation of molecular signalling pathways resembling apoptosis in nonneuronal cells. Cell surface cell death receptors and damage to mitochondria or DNA initiate these pathways finally leading to DNA fragmentation and cell death. Central mediators of delayed neuronal cell death are two families of molecules: a group of cysteine aspartate proteases, called caspases, and molecules of the bcl-2 family, e.g. bcl-2, bax, and bid. Caspases initiate and execute cell death, while bcl-2 family members modulate death signalling and lead to release of pro-apoptotic molecules from the mitochondrial intermembranous space, e.g. cytochrome c and apoptosis inducing factor (AIF). Cytochrome c induces cell death by activation of caspase 9 and 3, while AIF leads to detrimental DNA damage by an capaseindependent pathway. The current paper reviews recent findings dealing with pre- and post-mitochondrial cell death pathways activated by focal cerebral ischemia.

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Author information

Authors and Affiliations

  1. Institute for Surgical Research, University of Munich, Munich, Germany

    N. Plesnila

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  1. N. Plesnila
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Editors and Affiliations

  1. Institut für Chirurgische Forschung, Ludwig-Maximilians-Universität München, München, Germany

    A. Baethmann  & N. Plesnila  & 

  2. Neurochirurgische Klinik, Universität Würzburg, Würzburg, Germany

    J. Eriskat

  3. Neurochirurgische Klinik, Universität Freiburg, Freiburg, Germany

    J. Lehmberg

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© 2004 Springer-Verlag Wien

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Plesnila, N. (2004). Role of mitochondrial proteins for neuronal cell death after focal cerebral ischemia. In: Baethmann, A., Eriskat, J., Lehmberg, J., Plesnila, N. (eds) Mechanisms of Secondary Brain Damage from Trauma and Ischemia. Acta Neurochirurgica Supplements, vol 89. Springer, Vienna. https://doi.org/10.1007/978-3-7091-0603-7_3

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  • DOI: https://doi.org/10.1007/978-3-7091-0603-7_3

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-7091-7206-3

  • Online ISBN: 978-3-7091-0603-7

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