Summary
Our group investigated modulatory effects of apomorphine on cerebral activation patterns during finger tapping movements in six healthy right-handed volunteers using an established fMRI protocol. Apomorphine application disclosed a reduction of cerebral activation to the contralateral precentral and postcentral gyrus and ipsilateral cerebellum, with a prominent net reduction of BOLD signal in cerebellar areas. These findings contradict those of similar studies performed on dopaminergic function and Parkinson’s disease (PD), which predominantly found augmentation of cerebral activation patterns in normal volunteers and PD patients after dopaminergic stimulation . One conceivable explanation for our singular results would be preferred binding of apomorphine to presynaptic dopaminergic receptors, leading to inhibition of endogenous dopamine release and resultant diminished dopaminergic stimulation, reflected in diminished cerebral activation patterns. These findings warrant future consideration and further investigation of possible central inhibitory effects of dopaminergic therapy in functional imaging studies of the dopaminergic system in general and PD in particular.
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References
Alexander GE, Crutcher MD, Delong MD (1990) Basal ganglia thalamo-cortical circuits: parallel substrates for motor, oculomotor, “prefrontal” and “limbic” functions. Prog Brain Res 85: 119–146
Buhmann C, Glauche V, Stürenburg HJ, Oechsner M, Weiller C, Büchel C (2003) Pharmacologically modulated fMRI-cortical responsiveness to levodopa in drug-naive hemiparkinsonian patients. Brain 126: 451–461
Catalan MJ, Honda M, Weeks RA, Cohen LG, Hallett M (1998) The functional neuroanatomy of simple and complex sequential finger movements: a PET study. Brain 121: 253–264
Deiber MP, Honda M, Ibanez V, Sadato N, Hallett M (1999) Mesial motor areas in self-initiated versus externally triggered movements examined with fMRI: effect of movement type and rate. J Neurophysiol 81: 3065–3077
de la Fuente-Fernandez R, Lim AS, Sossi V, Holden JE, Calne DB, Ruth TJ, Stoessl AJ (2001) Apomorphine-induced changes in synaptic dopamine levels: positron emission tomography evidence for presynaptic inhibition. J Cereb Blood Flow Metab 21: 1151–1159
Duncan J, Seitz RJ, Kolodny J, Bor O, Herzog H, Ahmed A, Newell FN, Emslie H (2000) A neura l basis for general intelligence. Science 289: 457–460
Grasby PM, Friston KJ, Bench CJ, Frith CD, Paulesu E, Cowen PJ, Liddle PF, Frackowiak RS, Dolan R (1992) The effect of apomorphine and buspirone on regional cerebral blood flow during the performance of a cognitive task — measuring neuromodulatory effects of psychotrophic drugs in man. Eur J Neurosci 4: 1203–1212
Grasby PM, Friston KJ, Bench CJ, Cowen PJ, Frith CD, Liddle PF, Frackowiak RS, Dolan RJ (1993) The effect of the dopamine agonist, apomorphine, on regional cerebral blood flow in normal volunteers. Psychol Med 23: 605–612
Haaland KY, Yeo RA (1989) Neuropsychological functional and neuroanatomic aspects of complex motor control. In: Bigler EO, Yeo RA, Turkheimer E (eds) Neuropsychological function and brain imaging. Plenum New York, pp 219–243
Haslinger B, Erhard P, Kampfe N, Boecker H, Rummeny E, Schwaiger M, Conrad B, Ceballos-Baumann AO (2001) Event-related functional magnetic resonance imaging in Parkinson’s disease before and after levodopa. Brain 124: 558–570
Humberstone M, Sawle GV, Clare S, Hykin J, Coxon R, Bowtell R, Macdonald lA, Morris PG (1997) Functional magnetic resonance imaging of single motor events reveal human presupplementary motor area. Ann Neurol 42: 632–637
Jenkins IH, Fernandez W, Playford ED, Lees AJ, Frackowiak RSJ, Passingham RE, Brooks DJ (1992) Impaired activation of the supplementary motor area in Park inson’s disease is reversed when akinesia is treated with apomorphine. Ann Neurol 32: 749–757
Kapur S, Meyer J, Wilson AA, Houle S, Brown GM (1994) Activation of specific cortical regions by apomorphine: an [15O]H2O PET study in humans. Neurosci Lett 176: 21–24
Lal S (1988) Apomorphine in the evaluation of dopaminergic function in man. Prog Neuropsychopharmacol Biol Psychiatry 12: 117–164
Lepage M, Beaudoin G, Boulet C, O’Brien I, Marcantoni W, Bourgouin P, Richer F (1999) Frontal cortex and the programming of repetitive tapping movements in man: lesion effects and functional neuroimaging. Brain Res Cogn Brain Res 8: 17–25
McCulloch J, Teasdale G (1979) Effects of apomorphine upon local cerebral blood flow. Eur J Pharmacol 55: 99–102
Menon V, Glover GH, Pfefferbaum A (1998) Differential activation of dorsal basal ganglia during externally and self paced sequences of arm movements. Neuroreport 9: 1567–1573
Moriyama T, Yamanouchi N, Kodama K, Murakami A, Okada SI, Noda S, Komatsu N, Sato T, Kusaka T, Kato K (1998) Activation of non-primary motor areas during a complex finger movement task revealed by functional magnetic resonance imaging. Psychiatry Clin Neurosci 52: 339–343
Oldfield RC (1971) The assessment and analysis of handedness: the Edinburgh inventory. Neuropsychologia 9: 97–113
Peters S, Suchan B, Rusin J, Daum I, Köster O, Przuntek H, Müller T, Schmid G (2003) Apomorphine reduces BOLD signal in tMRI during voluntary movement in Parkinsonian patients. Neuroreport 14: 809–812
Rao SM, Binder JR, Bandetti PA, Hammeke TA, Yetkin FZ, Jesmanowicz A, Lisk LM, Morris GL Mueller WM, Estowski LD, Wong EC, Haughton VM, Hyde JS (1993) Functional magnetic resonance imaging of complex human movements. Neurology 43: 2311–2318
Rascol O, Sabatini U, Chollet F, Celsis P, Montastruc JL, Marc-Vergnes JP, Rascol A (1992) Supplementary and primary sensory motor area activity in Parkinson’s disease. Arch Neurol 49: 144–148
Rascol O, Sabatini U, Chollet F, Fabre N, Senard JM, Montastruc JL, Celsis P, Marc-Vergnes JP, Rascol A (1994) Normal activation of the supplementary motor area in patients with Parkinson’s disease undergoing long-term treatment with levodopa. J Neurol Neurosurg Psychiatry 5: 567–571
Reichenbach JR, Feiwell R, Kuppusamy K, Bahn M, Haacje EM (1998) Functional magnetic resonance imaging of the basal ganglia and cerebellum using a simple motor paradigm. Magn Reson Imaging 16: 281–287
Sabatini U, Boulanouar K, Fabre N, Martin F, Carel C, Colonnese C, Bozzao L, Berry I, Montastruc JL, Chollet F, Rascol O (2000) Cortical motor reorganization in akinetic patients with Parkinson’s disease — a functional MRI study. Brain 123: 394–403
Shibasaki H, Sadato N, Lyshkow H, Yonekura Y, Honda M, Nagamine T, Suwazono S, Magata Y, Ikeda A, Miyazaki M, Fukuyama H, Asato R, Konishi J (1993) Both primary motor cortex and supplementary motor area play an important role in complex finger movement. Brain 116: 1387–1398
Skirboll LR, Grace AA, Bunney BS (1979) Dopamine auto-and postsynaptic receptors: electrophysiological evidence for differential sensitivity to dopamine agonists. Science 206: 89–92
Tada Y (1998) Motor association cortex activity in Parkinson’s disease — a functional MRI study. Rinsho Shingeigaku 8: 729–735
Talairach J, Toumoux P (1988) Co-planar stereotaxic atlas of the human brain. Thieme Stuttgart
Toyokura M, Muro I, Komiya T, Obara M (2002) Activation of pre-supplementary motor area (SMA) and SMA proper during unimanual and bimanual complex sequences: an analysis using functional magnetic resonance imaging. J Neuroimaging 12: 172–178
van Oostende S, van Hecke P, Sunaert S, Nuttin B, Marchal G (1997) tMRI studies of the supplementary motor area and the premotor cortex. Neuroimage 6: 181–190
Wexler BE, Fulbright RK, Lacadie CM, Skudlarski P, Kelz MB, Constable RT, Gore JC (1997) An tMRI study of the human cortical motor system response to increasing functional demands. Magn Reson Imaging 15: 385–396
Wildgruber D, Erb M, Klose U, Grodd W (1997) Sequential activation of supplementary motor area and primary motor cortex during self-paced finger movement in human evaluated by functional MRI. Neurosci Lett 227: 161–164
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Schmid, G. et al. (2004). Impact of apomorphine on BOLD signal during movement in normals. In: Müller, T., Riederer, P. (eds) Focus on Extrapyramidal Dysfunction. Journal of Neural Transmission. Supplementa, vol 68. Springer, Vienna. https://doi.org/10.1007/978-3-7091-0579-5_8
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DOI: https://doi.org/10.1007/978-3-7091-0579-5_8
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