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Osteoimmunological Aspects of Biomechanics

  • Chapter
Principles of Osteoimmunology

Abstract

Osteoporosis and fragility fractures are a major health concern, especially in industrialised countries. Osteoporosis per se and osteoporosis-related complications may impair functioning and health and, thus, lead to an inferior quality of life. Moreover, skeletal health has a profound financial and social impact.

Different endogenous and exogenous factors which interfere with bone health have been identified. Among these, physical activity that relates to regular mechanical bone loading seems to be one of the major factors controlling bone mass and the prevention of osteoporotic fractures. Moreover, there is an interaction between bone homeostasis and the immune system which may be modified by regular physical activity. Bone and immune cells share a common site of origin, the bone marrow. They are supposed to influence each other not only during maturation; osteoclasts and immune cells have a number of regulatory molecules in common, including cytokines, receptors, signalling molecules, and transcription factors, which influence each other.

The aim of this chapter is to review the impact of both bone loading and muscle activity on bone remodelling, thereby elucidating the immunological communication pathways intended to modulate osteoblast and osteoclast activity.

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Authors and Affiliations

  1. Department of Physical Medicine and Rehabilitation, Medical University of Vienna, Währinger Gürtel 18–20, 1090, Vienna, Austria

    Katharina Kerschan-Schindl & Gerold Ebenbichler

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  1. Katharina Kerschan-Schindl
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  2. Gerold Ebenbichler
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Correspondence to Katharina Kerschan-Schindl .

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  1. Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria

    Peter Pietschmann

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Kerschan-Schindl, K., Ebenbichler, G. (2012). Osteoimmunological Aspects of Biomechanics. In: Pietschmann, P. (eds) Principles of Osteoimmunology. Springer, Vienna. https://doi.org/10.1007/978-3-7091-0520-7_5

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