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From Traditional to Evidence-Based Use of Hippophae rhamnoides L.: Chemical Composition, Experimental, and Clinical Pharmacology of Sea Buckthorn Berries and Leaves Extracts

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Evidence and Rational Based Research on Chinese Drugs

Abstract

Various processed products from Sea Buckthorn (Hippophae rhamnoides L.) berries, seeds, and leaves are used in China and other countries as functional food, dietary supplements, and medicines. Growing interest to this plant is mainly due to a high nutritional value of berries and potential health effects of leaves and bark. This monograph provides comprehensive up to date information about medicinal uses, chemical composition and analysis, experimental and clinical pharmacology, safety, posology of Sea Buckthorn extracts/products, their adverse events, and interactions with drugs. The results of pharmacological and clinical studies of the sea buckthorn products are reviewed with the aim to evaluate the level of scientific evidences supporting the health claims and the indications for use.

Further research on this promising herbal medicine seems warranted.

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Notes

  1. 1.

    Synonyms: Elaeagnus rhamnoides (L.) A. Nelson, Hippophae angustifolia Lodd., Hippophae littoralis Salisb., Hippophae rhamnoideum Saint-Lager, Hippophae sibirica Lodd., Hippophae stourdziana Szabó, Osyris rhamnoides Scop., Rhamnoides hippophae Moench

    Common names: The Chinese name for Sea Buckthorn is 沙棘, pinyin shājí sha1ji2, literally “sand thorn.” Sea Buckthorn is called, Star-Bu or Dhar-Bu in Tibet, Dalechuk in Nepal; Yashildoo Chatsargana in Mongolia, Oblepikha in Russia, Tibet Sajee omm Japan, Seedorn in Germany, Argousier in France, Espino Amarillo in Spain, Finbär in Sweden, Tindved in Denmark, Rokitnik in Poland, Smiltserkskis in Latvia, Chichkhan in Armenia [Watanabe et al. 2005; Pakalns 2002; Natural Medicines Comprehensive Database 2011; Sea buckthorn (Hippophae rhamnoides) 2011]. Sea Buckthorn is also known as “Siberian Pineapple.”

  2. 2.

    Definitions from Natural Medicines Comprehensive Database

    http://naturaldatabase.therapeuticresearch.com/home.aspx?cs=%26s=ND

    Likely safe: This product has a very high level of reliable clinical evidence showing its safe use when used appropriately. Products rated Likely Safe are generally considered appropriate to recommend.

    Possibly safe: This product has some clinical evidence showing its safe use when used appropriately; however, the evidence is limited by quantity, quality, or contradictory findings. Products rated “Possibly Safe” appear to be safe but do not have enough high-quality evidence to recommend for most people.

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  1. Swedish Herbal Institute, Kövlingevägen 21, 31250, Vallberga, Sweden

    Alexander Panossian

  2. Department of Pharmacy, Center of Pharma Research, Ludwig-Maximilians-University Munich, Butenandtstr. 5, 81377, Munich, Germany

    Hildebert Wagner

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    Hildebert Wagner

  2. , Rheinische Friedrich-Wilhelms-University, Medical Policlinic/Medical Clinic III, Wilhelmstrasse 35-37, Bonn, 53111, Germany

    Gudrun Ulrich-Merzenich

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Panossian, A., Wagner, H. (2013). From Traditional to Evidence-Based Use of Hippophae rhamnoides L.: Chemical Composition, Experimental, and Clinical Pharmacology of Sea Buckthorn Berries and Leaves Extracts. In: Wagner, H., Ulrich-Merzenich, G. (eds) Evidence and Rational Based Research on Chinese Drugs. Springer, Vienna. https://doi.org/10.1007/978-3-7091-0442-2_5

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