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Ginkgo biloba Extract EGb 761®: From an Ancient Asian Plant to a Modern European Herbal Medicinal Product

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Evidence and Rational Based Research on Chinese Drugs

Abstract

This chapter differs from the other chapters in the book in a number of aspects. First of all, it is not about traditional Chinese medicine (TCM) and hence does not describe internationally recognized standards which need to be established in the future to scientifically validate the traditional expertise on TCM. Rather, this chapter outlines the development process and present knowledge on EGb 761®, a special extract from leaves of Ginkgo biloba L. Although EGb 761® is produced from a plant which is native to China and other Asian countries; the extract was developed as a Western medicine.

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References

  • Abdel-Kader RM, Hauptmann S, Keil U, Scherping I, Leuner K, Eckert A, Mueller WE (2007) Stabilization of mitochondrial function by Ginkgo biloba extract (EGb 761). Pharmacol Res 56(6):493–502

    Google Scholar 

  • Aisen PS, Andrieu S, Sampaio C, Carrillo M, Khatchaturian ZS, Dubois B, Feldman HH, Petersen RC, Siemers E, Doody RS, Hendrix SB, Grundman M, Schneider LS, Schindler RJ, Salmon E, Potter WZ, Thomas RG, Salmon D, Donohue M, Bednar MM, Touchon J, Vellas B (2011) Report of the task force on designing clinical trials in early (predementia) AD. Neurology 76:280–286

    Google Scholar 

  • Aldridge WN, Street BW, Skilleter DN (1977) Oxidative phosphorylation. Halide-dependent and halide-independent effects of triorganotin and trioganolead compounds on mitochondrial functions. Biochem J 168:353–64

    PubMed  CAS  Google Scholar 

  • Arenz A, Klein M, Fiehe K, Gross J, Drewke C, Hemscheidt T, Leistner E (1996) Occurrence and biosynthesis of neurotoxic 4'-O-methylpyridoxine in Ginkgo biloba [Abstr. SL 20], 44th Annu. Congr. Med. Plant Res., Prague, CZ, 3.-7.9.1996, p 25

    Google Scholar 

  • Arenz A, Klein M, Fiehe K, Gross J, Drewke C, Hemscheidt T, Eckhard L (1996b) Occurrence of neurotoxic 4'-O-methylpyridoxine in Ginkgo biloba leaves, Ginkgo medications and Japanese Ginkgo food. Planta Med 62(6):548–551

    PubMed  CAS  Google Scholar 

  • Auguet M, Clostre F, De Feudis FV (1986) Effects of antidepressants on receptor-activated and Ca2+-activated contractions of rabbit isolated aorta. Gen Pharmacol 17:607–610

    PubMed  CAS  Google Scholar 

  • Augustin S, Rimbach G, Augustin K, Schliebs R, Wolffram S, Cermak R (2009) Effect of a short- and long-treatment with Ginkgo biloba extract on amyloid precursor protein levels in a transgenic mouse model relevant to Alzheimer’s disease. Arch Biochem Biophys 481:177–182

    PubMed  CAS  Google Scholar 

  • Ahlemeyer B, Krieglstein J (2003) Pharmacological studies supporting the therapeutic use of Ginkgo biloba extract for Alzheimer's disease. Pharmacopsychiatry 36(Suppl. 1): S8–S14

    PubMed  CAS  Google Scholar 

  • Barkats M, Venault P, Christen Y, Cohen-Salmon C (1995) Effect of long-term treatment with EGb 761® on age-dependent structural changes in the hippocampi of three inbred mouse strains. Life Sci 56:213–222

    PubMed  CAS  Google Scholar 

  • Barth SA, Inselmann G, Engemann R, Heidemann HT (1991) Influences of Ginkgo biloba on cyclosporin A induced lipid peroxidation in human liver microsomes comparison to vitamin E, glutathione and N-acetylcysteine. Biochem Pharmacol 41:1521–1526

    PubMed  CAS  Google Scholar 

  • Bastianetto S, Ramassamy C, Doré S, Christen Y, Poirier J, Quirion R (2000) The Ginkgo biloba extract (EGb 761®) protects hippocampal neurons against cell death induced by beta-amyloid. Eur J Neurosci 12:1882–90

    PubMed  CAS  Google Scholar 

  • Bennett DA, Wilson RS, Schneider JA, Evans DA, Beckett LA, Aggarwal NT, Barnes LL, Fox JH, Bach J (2002) Natural history of mild cognitive impairment in older persons. Neurology 59:198–205

    PubMed  CAS  Google Scholar 

  • Biber A, Koch E (1999) Bioavailability of ginkgolides and bilobalide from extracts of Ginkgo biloba using GC/MS. Planta Med 65:192–193

    PubMed  CAS  Google Scholar 

  • Biber A (2003) Pharmacokinetics of Ginkgo biloba extracts. Pharmacopsychiatry 36(Suppl. 1):S32–S37

    Google Scholar 

  • Blecharz-Klin K, Piechal A, Joniec I, Pyrzanowska J, Widy-Tyszkiewicz E (2009) Pharmacological and biochemical effects of Ginkgo biloba extract on learning, memory consolidation and motor activity in old rats. Acta Neurobiol Exp 69:217–231

    Google Scholar 

  • Blume J, Kieser M, Hölscher U (1996) Placebo-controlled double blind study on the efficacy of Ginkgo biloba special extract EGb 761® in maximum level trained patients with intermittent claudication (in German). Vasa 25:265–274

    PubMed  CAS  Google Scholar 

  • Blumenthal M, Busse WR, Goldberg A, Gruenwald J, Hall T, Riggins CW, Rister RS, Klein S (1998) The complete German commission E monographs therapeutic guide to herbal medicines developed by a special expert Committee of the German Federal Institute for Drugs and Medical Devices. Am. Bot. Counc., Austin, TX, USA

    Google Scholar 

  • Boulie R, Munoz JF, Macovshi Panes O, Pacheco H (1988) Implication de la peroxidation lipidique dans l’intoxication par le triethyletain chez le rat. C R Seances Soc Biol Ses Fil 182:196–201

    Google Scholar 

  • Braquet P (1987) The ginkgolides: potent platelet-activating factor antagonists’ isolated from Ginkgo biloba L.: chemistry, pharmacology and clinical applications. Drugs Fut 12:643–699

    Google Scholar 

  • Bulling B, von Bary S (1991) The treatment of chronic peripheral arterial occlusion disease with physical exercise and Ginkgo biloba extract 761 (in German). Medwelt 42:702–708

    Google Scholar 

  • Chandrasekaran K, Mehrabian Z, Spinnewyn B, Chinopoulos C, Drieu K, Fiskum G (2002) Bilobalide, a component of the Ginkgo biloba extract (EGb 761®), protects against neuronal death in global brain ischemia and in glutamate-induced excitotoxicity. Cell Mol Biol 48:663–669

    PubMed  CAS  Google Scholar 

  • Chatterjee SS (1985) Effect of Ginkgo biloba extract on cerebral metabolic processes. In: Agnoli A, Rapin JR, Scapagnini V, Weibrecht WV (eds) Effect of Ginkgo biloba extract on organic cerebral impairment. John Libbey Eurotext, London, pp 5–15

    Google Scholar 

  • Chatterjee SS, Gabard BL (1981) Protective effect of an extract of Ginkgo biloba and other hydroxyl radical scavengers against hypoxia [Abstr. 866]. IUPHAR 8th Int. Congr. Pharmacol. Tokyo, JP 19.7.1981–24.7.1981, p 483

    Google Scholar 

  • Chatterjee SS, Gabard BL (1982a) Studies on the mechanism of action of an extract of Ginkgo biloba, a drug used for treatment of ischemic vascular diseases [Abstr. 207]. Naunyn Schmiedeberg’s Arch Pharmacol 321(suppl):R52

    Google Scholar 

  • Chatterjee SS, Gabard BL (1982b) Protection of doxorubicin toxicity by an extract of Ginkgo biloba [Abstr. 57]. Naunyn Schmiedeberg’s Arch Pharmacol 319(suppl):R15

    Google Scholar 

  • Chatterjee SS, Gabard BL (1984) Effect of an extract of Ginkgo biloba on experimental neurotoxicities [Abstr. 327]. Naunyn Schmiedeberg’s Arch Pharmacol 325(suppl):R82

    Google Scholar 

  • Chatterjee SS, Noeldner M (1989) Behavioural observations demonstrating influences of the extract of Ginkgo biloba (EGb 761®) on some specific central cholinergic systems [Abstr. 425]. Naunyn Schmiedeberg’s Arch Pharmacol 339(suppl):R107

    Google Scholar 

  • Chatterjee SS, Cees J, Doelman A, Nöldner M, Biber A, Koch E (2005) Influence of the Ginkgo extract EGb 761® on rat liver cytochrome P450 and metabolism and excretion in rats and man. J Pharm Pharmacol 57:1–10

    Google Scholar 

  • Christen Y (2004) Ginkgo biloba and neurodegenerative disorders. Front Biosci 9:3091–3104

    PubMed  CAS  Google Scholar 

  • Christen Y (2010) Does Ginkgo biloba extract exert an effect on Alzheimer’s disease progression? [Chap. 17]. In: Micronutrients and brain health. Taylor & Francis, Boca Raton, FL, USA, Oxid Stress Dis 26:243–254

  • Cohen-Salmon C, Venault P, Martin B, Raffalli-Sébille MJ, Barkats M, Clostre F, Pardon MC, Christen Y, Chapouthier G (1997) Effects of Ginkgo biloba extract (EGb 761®) on learning and possible actions on aging. J Physiol Paris 91:291–300

    PubMed  CAS  Google Scholar 

  • Colciaghi F, Borroni B, Zimmermann M, Bellone C, Longhi A, Padovani A, Cattabeni F, Christen Y, Di Luca M (2004) Amyloid precursor protein metabolism is regulated toward alpha-secretase pathway by Ginkgo biloba extracts. Neurobiol Dis 16:454–460

    PubMed  Google Scholar 

  • Continella G, Drago F (1984) Behavioral effect of Ginkgo biloba extract. In: Agnoli A, Rapin JR, Scapagnini V, Weitbrecht WV (eds) Effects of Ginkgo biloba-extract on organic cerebral impairment. John Libbey, London, pp 35–42

    Google Scholar 

  • De Feudis FV (2003) Ginkgo biloba extract, from chemistry to the clinic. Urban & Fischer, Munich

    Google Scholar 

  • De Kosky ST, Williamson J, Fitzpatrick A, Kronmal RA, Ives DG, Saxton J, Lopez O, Burke G, Carlson M, Fried L, Kuller LH, Robbins J, Tracy RP, Woolard NF, Dunn L, Snitz BE, Nahin RL, Furberg CD, for the GEM Study Investigators (2008) Ginkgo biloba for primary prevention of dementia: results of the Ginkgo evaluation of memory (GEM) study. JAMA 300:2253–2262

    Google Scholar 

  • De Marchi U, Campello S, Szabò I, Tombola F, Martinou JC, Zoratti M (2004) Bax does not directly participate in the Ca(2+)-induced permeability transition of isolated mitochondira. J Biol Chem 279:37415–22

    PubMed  Google Scholar 

  • Dorman DC, Cote LM, Buck WB (1992) Effects of an extract of Ginkgo biloba on bromethalin-induced cerebral lipid peroxidation and edema in rats. Am J Vet Res 53:138–142

    PubMed  CAS  Google Scholar 

  • Dumont E, Petit E, Tarrade T, Nouvelot A (1992) UV-C irradiation-induced peroxidative degradation of microsomal fatty acids and proteins: protection by an extract of Ginkgo biloba (EGb 761®). Free Radic Biol Med 13:197–203

    PubMed  CAS  Google Scholar 

  • Eckert A, Keil U, Scherping I, Hauptmann S, Mueller WE (2005) Stabilization of mitochondrial membrane potential and improvement of neuronal energy metabolism by Ginkgo biloba extract EGb 761®. Ann N Y Acad Sci 1056:474–485

    PubMed  Google Scholar 

  • EMEA/CHMP/SWP/431994 (2007) Guideline on the limits of genotoxic impurities

    Google Scholar 

  • Emerit I, Arutyunyan R, Oganesian N, Levy A, Cernjavsky L, Sarkisian T, Pogossian A, Asrian K (1995) Radiation-induced clastogenic factors: anticlastogenic effect of Ginkgo biloba extract. Free Radic Biol Med 18:985–991

    PubMed  CAS  Google Scholar 

  • Erdinçler DS, Karakoç Y, Toplan S, Önen S, Sukyasyan A, Beğer T, Demiroğlu Ç (1996) The effect of Ginkgo biloba glycoside on the blood viscosity and erythrocyte deformability. Clin Hemorheol 16:271–276

    Google Scholar 

  • ESCOP (2003) Ginkgo biloba, Euro. Sci. Cooperative Phytother. (ESCOP). Thieme, Stuttgart

    Google Scholar 

  • Fehske CJ, Leuner K, Müller WE (2009) Ginkgo biloba extract (EGb 761®) influences monoaminergic neurotransmission via inhibition of NE uptake, but not MAO activity after chronic treatment. Pharmacol Res 60:68–73

    PubMed  CAS  Google Scholar 

  • Fitzl G, Welt K, Martin R, Dettmer D, Hermsdorf T, Clemens N, Konig S (2000) The influence of hypoxia on the myocardium of experimentally diabetic rats with and without protection by Ginkgo biloba extract. I. Ultrastructural and biochemical investigations on cardiomyocytes. Exp Toxicol Pathol 52:419–30

    PubMed  CAS  Google Scholar 

  • Fourtillan JB, Brisson AM, Girault J, Ingrand I, Decourt JP, Drieu K, Jouenne P, Biber A (1995) Proprietes pharmacocinetiques du Bilobalide et des Ginkgolides A et B chez le sujet sain apres administrations intraveneuses et orals d'extrait de Ginkgo biloba (EGb-761®) [Pharmacokinetics of bilobalide, Ginkgolide A and Ginkgolide B in healthy volunteers following oral and intravenous administrations of Ginkgo biloba extract (EGb 761®)]. Therapie 50(2):137–144

    PubMed  CAS  Google Scholar 

  • Fransen HP (2010) Assessment of health claims, content, and safety of herbal supplements containing Ginkgo biloba. Food Nutr Res 54:5221

    Google Scholar 

  • Garcia-Alloza M, Dodwell SA, Meyer-Luehmann M, Hyman BT, Bacskai BJ (2006) Plaque-derived oxidative stress mediates distorted neurite trajectories in the Alzheimer mouse model. J Neuropathol Exp Neurol 65:1082–9

    PubMed  CAS  Google Scholar 

  • Gawron-Gzella A, Marek P, Chanay J, Matlawska I (2010) Comparative analysis of aharmaceuticals and dietary supplements containing extracts from the leaves of Ginkgo biloba L. Acta Pol Pharm 67(4):335–43

    PubMed  CAS  Google Scholar 

  • Grass-Kapanke B, Busmane A, Lasmanis A, Hoerr R, Kaschel R (2011) Effects of Ginkgo biloba special extract EGb 761® in very mild cognitive impairment (vMCI). Neurosci Med 2:48–56

    Google Scholar 

  • Halama P, Bartsch G, Meng G (1988) Cerebrovascular insufficiency – placebo-controlled, randomised, doubleblind trial on the effect of Ginkgo biloba extract (in German). Fortschr Med 106:408–412

    PubMed  CAS  Google Scholar 

  • Hamann KF (2007) Ginkgo special extract EGb 761® in vertigo: a systematic review of randomised, double-blind, placebo-controlled clinical trials. Internet J Otorhinolaryngol 6(2)

    Google Scholar 

  • Heiss WD, Zeiler K (1978) Medikamentöse Beeinflussung der Hirndurchblutung. Pharmakotherapie 1:137–144

    Google Scholar 

  • Herrschaft H, Nacu A, Likhachev S, Sholomov I, Hoerr R, Schlaefke S, on behalf of the GOT-IT! Study Group (2012) Ginkgo biloba extract EGb 761(R) in dementia with neuropsychiatric features: a randomised, placebo-controlled trial to confirm the efficacy and safety of a daily dose of 240 mg. J Psychiatr Res 46:716–723

    Google Scholar 

  • Hofferberth B (1989) Effect of Ginkgo biloba extract on neurophysiological and psychometric measurement results in patients with cerebro-organic syndrome – a double-blind study versus placebo (in German). Arzneimittelforschung 39:918–922

    PubMed  CAS  Google Scholar 

  • Hofferberth B (1991) Simultanerfassung elektrophysiologischer, psychometrischer und rheologischer Parameter bei Patienten mit hirnorganischem Psychosyndrom und erhöhtem Gefäßrisiko – Eine placebokontrollierte Doppelblindstudie mit Ginkgo-biloba-Extrakt EGb 761®. In: Stodtmeister R, Pillunat LE (eds) Mikrozirkulation in Gehirn und Sinnesorganen. Enke, Stuttgart, pp 64–74

    Google Scholar 

  • Horsch S, Walther C (2004) Ginkgo biloba special extract EGb 761® in the treatment of peripheral arterial occlusive disease (PAOD) – a review based on randomized, controlled studies. Int J Clin Pharmacol Ther 42:63–72

    PubMed  CAS  Google Scholar 

  • Hoyer S, Lannert H, Noeldner M, Chatterjee SS (1999) Damaged neuronal energy metabolism and behavior are improved by Ginkgo biloba extract (EGb 761®). J Neural Transm 106:1171–1188

    PubMed  CAS  Google Scholar 

  • Hsu CL, Wu YL, Tang GJ, Lee TS, Kou YR (2009) Ginkgo biloba extract confers protection from cigarette smoke extract-induced apoptosis in human lung endothelial cells: role of heme oxygenase-1. Pulm Pharmacol Ther 22:286–296

    PubMed  CAS  Google Scholar 

  • Huang SH, Duke RK, Chebib M, Sasaki K, Wada K, Johnston GA (2003) Bilobalide, a sesquiterpene trilactone from Ginkgo biloba, is an antagonist at recombinant alpha1beta2gamma2L GABA(A) receptors. Eur J Pharmacol 464:1–8

    PubMed  CAS  Google Scholar 

  • Huguet F, Tarrade T (1992) Alpha2-adrenoceptor changes during cerebral ageing: the effect of Ginkgo biloba extract. J Pharm Pharmacol 44:24–27

    PubMed  CAS  Google Scholar 

  • Huguet F, Drieu K, Piriou A (1994) Decreased cerebral 5-HT1A receptors during ageing: reversal by Ginkgo biloba extract EGb 761®). J Pharm Pharmacol 46:316–318

    PubMed  CAS  Google Scholar 

  • Ihl R, Bachinskaya N, Korczyn AD, Vakhapova V, Tribanek M, Hoerr R, Napryeyenko O, on behalf of the GOTADAY Study Group (2011) Efficacy and safety of a once-daily formulation of Ginkgo biloba extract EGb 761® in dementia with neuropsychiatric features – a randomized controlled trial. Int J Geriatr Psychiatry 26:1186–1194

    Google Scholar 

  • IQWiG Institut für Qualität und Wirtschaftlichkeit im Gesundheitswesen (2008) Ginkgohaltige Präparate bei Alzheimer Demenz – Abschlussbericht A05–19B. IQWiG, Köln

    Google Scholar 

  • Israël L, Dell’Accio E, Martin G, Hugonot R (1987) Ginkgo biloba extract and memory training programs – comparative assessment on elderly outpatients living in the community (in French). Psychol Med (Paris) 19:1431–1439

    Google Scholar 

  • Ivic L, Sands TT, Fishkin N, Nakanishi K, Kriegstein AR, Strømgaard K (2003) Terpene trilactones from Ginkgo biloba are antagonists of cortical glycine and GABA(A) receptors. J Biol Chem 278:49279–85

    PubMed  CAS  Google Scholar 

  • Jack CR, Knopman DS, Jagust WJ, Shaw LM, Aisen PS, Weiner MW, Petersen RC, Trojanowski JQ (2010) Hypothetical model of dynamic biomarkers of the Alzheimer’s pathological cascade. Lancet Neurol 9:119–128

    PubMed  CAS  Google Scholar 

  • Jaggy H, Koch E (1997) Chemistry and biology of alkylphenols from Ginkgo biloba L. Pharmazie 52(10):735–738

    PubMed  CAS  Google Scholar 

  • Janssens D, Michiels C, Delaive E, Eliaers F, Drieu K, Remacle J (1995) Protection of hypoxia-induced ATP decrease in endothelial cells by Ginkgo biloba extract and Bilobalide. Biochem Pharmacol 50:991–999

    PubMed  CAS  Google Scholar 

  • Janssens D, Remacle J, Drieu K, Michiels C (1999) Protection of mitochondrial respiration activity by Bilobalide. Biochem Pharmacol 58:109–119

    PubMed  CAS  Google Scholar 

  • Janssens D, Delaive E, Remacle J, Michiels C (2000) Protection by bilobalide of the ischaemia-induced alterations of the mitochondrial respiratory activity. Fundam Clin Pharmacol 14:193–201

    PubMed  CAS  Google Scholar 

  • Jessen F, Wiese B, Bachmann C, Eifflaender-Gorfer S, Haller F, Kölsch H, Luck T, Mösch E, van den Bussche H, Wagner M, Wollny A, Zimmermann T, Pentzek M, Riedel-Heller SG, Romberg HP, Weyerer S, Kaduszkiewicz H, Maier W, Bickel H, for the German Study on Aging, Cognition and Dementia in Primary Care Patients Study Group (2010) Prediction of dementia by subjective memory impairment. Arch Gen Psychiatry 67:414–422

    PubMed  Google Scholar 

  • Kampkötter A, Pielarski T, Rohrig R, Timpel C, Chovolou Y, Wätjen W, Kahl R (2007) The Ginkgo biloba extract EGb 761® reduces stress sensitivity, ROS accumulation and expression of catalase and glutathione S-transferase 4 in Caenorhabditis elegans. Pharmacol Res 55:139–47

    PubMed  Google Scholar 

  • Kanowski S, Herrmann WM, Stephan K, Wierich W, Hörr R (1996) Proof of efficacy of the Ginkgo biloba special extract EGb 761® in outpatients suffering from mild to moderate primary degenerative dementia of the Alzheimer type or multi-infarct dementia. Pharmacopsychiatry 29:47–56

    PubMed  CAS  Google Scholar 

  • Karcher L, Zagrmann P, Krieglstein J (1984) Effect of an extract of Ginkgo biloba on rat brain energy metabolism in hypoxia. Naunyn-Schmiedeberg’s Arch Pharmacol 327:31–35

    CAS  Google Scholar 

  • Kaschel R, Hörr R, Kresimon J, Rychlik R (2007) Einfluss von Ginkgo-Spezialextrakt EGb 761® auf die Leistungsfähigkeit bei gesunden Probanden am Bildschirmarbeitsplatz – Offene klinische Studie im Prä-Post-Design mit Kontrollgruppe. Perfusion 16:3–9

    Google Scholar 

  • Kasper S, Schubert H (2009) Ginkgo biloba extract EGb 761® in the treatment of dementia: evidence of efficacy and tolerability (in German). Fortschr Neurol Psychiatr 77:494–506

    PubMed  CAS  Google Scholar 

  • Keles MS, Demirci N, Yildirim A, Atamanalp SS, Altinkaynak K (2008) Protective effects of N-acetylcysteine and Ginkgo biloba extract on ischaemia-reperfusion-induced hepatic DNA damage in rats. Clin Exp Med 8:193–8

    PubMed  Google Scholar 

  • Kellermann AJ, Kloft C (2011) Is there a risk of bleeding associated with standardized Ginkgo biloba extract therapy? A systematic review and meta-analysis. Pharmacotherapy 31:490–502

    PubMed  CAS  Google Scholar 

  • Klein J, Chatterjee SS, Loeffelholz K (1995) Hypoxia-induced release of choline from rat brain: potent inhibition by bilobalide. Biol Chem Hoppe-Seyler 376(suppl):S116

    Google Scholar 

  • Klein J, Chatterjee SS, Loeffelholz K (1997) Phospholipid breakdown and choline release under hypoxic conditions: inhibition by bilobalide, a constituent of Ginkgo biloba. Brain Res 755:347–350

    PubMed  CAS  Google Scholar 

  • Klein J, Weichel O, Hilgert M, Rupp J, Chatterjee SS, Nawrath H (2003) Excitotoxic hippocampal membrane breakdown and its inhibition by bilobalide: role of chloride fluxes. Pharmacopsychiatry 36(suppl 1):78–83

    Google Scholar 

  • Koch E (2005) Inhibition of platelet activating factor (PAF)-induced aggregation of human thrombocytes by ginkgolides: considerations on possible bleeding complications after oral intake of Ginkgo biloba extracts. Phytomedicine 12:10–16

    PubMed  CAS  Google Scholar 

  • Koch E, Chatterjee SS (1993) Experimentelle Grundlagen fuer die therapeutische Anwendung von Ginkgoextrakt EGb 761® bei der Behandlung vaskulaerer Erkrankungen. Haemostaseologie 13:11–27

    CAS  Google Scholar 

  • Koh PO (2009) Ginkgo biloba extract (EGb 761®) prevents increase of Bad-Bcl-X(L) interaction following cerebral ischemia. Am J Chin Med 37:867–876

    PubMed  Google Scholar 

  • Koltermann A (2007) Influence of Ginkgo biloba extract EGb 761® on signaling pathways in endothelial cells. Dissertation, Pharm Biol Pharm, Ludwig-Maximilians-Universitaet, Muenchen DE. p 155

    Google Scholar 

  • Költringer P, Langsteger W, Eber O (1995) Dose-dependent hemorheological effects and microcirulatory modifications following intravenous administration of Ginkgo biloba special extract EGb 761®. Clin Hemorheol 15:649–656

    Google Scholar 

  • Krieglstein J, Beck T, Seibert A (1986) Influence of an extract of Ginkgo biloba on cerebral blood flow and metabolism. Life Sci 39:2327–34

    PubMed  CAS  Google Scholar 

  • Krieglstein J, Ausmeier F, El-Abhar H, Lippert K, Welsch M, Rupalla K, Henrich-Noack P (1995) Neuroprotective effects of Ginkgo biloba constituents. Eur J Pharm Sci 3:39–48

    CAS  Google Scholar 

  • Kristofikova Z, Benesova O, Tejkalova H (1992) Changes of high-affinity choline uptake in the hippocampus of old rats after long-term administration of two nootropic drugs (Tacrine and Ginkgo biloba extract). Dementia 3:304–307

    Google Scholar 

  • Krzywon M, Tawab M, Schubert-Zsilavecz M (2008) Ginkgohaltige Teeprodukte nicht ohne Risiko. Pharm Ztg 153(13):4474–4479

    Google Scholar 

  • Le Bars PL, Katz MM, Berman N, Itil TM, Freedman AM, Schatzberg AF, for the North American EGb Study Group (1997) A placebo-controlled, double-blind randomized trial of an extract of Ginkgo biloba for dementia. JAMA 278:1327–1332

    PubMed  Google Scholar 

  • Le Poncin-Lafitte M, Rapin J, Rapin JR (1980) Effects of Ginkgo Biloba on changes induced by quantitative cerebral microembolization in rats. Arch Int Pharmacodyn Ther 243:236–44

    PubMed  Google Scholar 

  • Leistner E, Drewke C (2010a) Ginkgo biloba and ginkgotoxin. J Nat Prod 73:86–92

    PubMed  CAS  Google Scholar 

  • Leistner E, Drewke C (2010b) Arznei- und Nahrungsmittel aus Ginkgo biloba Potenziell toxische Inhaltsstoffe und ihre Wirkmechanismen [Drug and nutrition aspects of Ginkgo biloba] Dtsch. Apoth Ztg 150(17):1930–1935

    Google Scholar 

  • Lin FY, Chen YH, Chen YL, Wu TC, Li CY, Chen JW, Lin SJ (2007) Ginkgo biloba extract inhibits endotoxin-induced human aortic smooth muscle cell proliferation via suppression of toll-like receptor 4 expression and NADPH oxidase activation. J Agric Food Chem 55:1977–1984

    PubMed  CAS  Google Scholar 

  • Liu KX, Wu WK, He W, Liu CL (2007) Ginkgo biloba extract (EGb 761®) attenuates lung injury induced by intestinal ischemia/reperfusion in rats: roles of oxidative stress and nitric oxide. World J Gastroenterol 14:299–305

    Google Scholar 

  • Longpre F, Garneau P, Christen Y, Ramassamy C (2006) Protection by EGb 761® against beta-amyloid-induced neurotoxicity: involvement of NF-kappa B, SIRT1, and MAPKs pathways and inhibition of amyloid fibril formation. Free Radic Biol Med 41:1781–1794

    PubMed  CAS  Google Scholar 

  • Luo Y, Smith JV, Paramasivam V, Burdick A, Curry KJ, Buford JP, Khan I, Netzer WJ, Xu H, Butko P (2002) Inhibition of amyloid-beta aggregation and caspase-3 activation by the Ginkgo biloba extract EGb761. Proc Natl Acad Sci USA 99:12197–202

    PubMed  CAS  Google Scholar 

  • Mahadevan S, Park Y (2008) Multifaceted therapeutic benefits of Ginkgo biloba L.: chemistry, efficacy, safety, and uses. J Food Sci 73:R14–R19

    PubMed  CAS  Google Scholar 

  • Martin R, Mozet C, Martin H, Welt K, Engel C, Fitzl G. (2010) Effect of Ginkgo biloba extract ( EGb 761® ) on parameters of oxidative stress in different regions of aging rat brain after acute hypoxia. Aging Clin. Exp. Res. [Epub ahead of print], DOI: 10.3275/7229

    Google Scholar 

  • Meier B, Hasler A, Sticher O (1992) HPLC analyses of the main Ginkgo acylflavonol glycosides. Planta Med 58(suppl 7):A688–A689

    Google Scholar 

  • Meyer B (1986) A mulitcentre, randomized, double-blind drug versus placebo study of Ginkgo biloba extract in the treatment of tinnitus (in French). Presse Med 15:1562–1564

    PubMed  CAS  Google Scholar 

  • Mizuno M, Droy-Lefaix MT, Packer L (1996) Ginkgo biloba extract EGb 761® is a suppressor of AP-1 transcription factor stimulated by phorbol 12-myristate 13-acetate. Biochem Mol Biol Int 39:395–401

    PubMed  CAS  Google Scholar 

  • Moeller CK, Kurt S, Scheich H, Schulze H (2009) Improvement of auditory discrimination learning by Ginkgo biloba extract EGb 761® (R). Neurosci Lett 463:219–222

    PubMed  CAS  Google Scholar 

  • Moreau P (1975) Un nouveau stimulant circulatoire cérébral. Nouv Presse Med 4:2401–2402

    PubMed  CAS  Google Scholar 

  • Moreau J-P, Bommelaer G, Buscail L, Benque A, Jacob CO, Galleyrand J, Ribet (1986) A preliminary results of a multicentric double blind trial of somatostatin [s] vs placebo [p] in akute pancreatitis [ap] [Abstr. 85], 8th Congr. Gastroenterol. (OMGE), 6th Congr. Dig. Endosc. (OMED), 3rd. Congr. Colo-Proctol., Sao Paolo BR, 7.-12.9.1986, Dig Dis Sci 31(10, Suppl.)

    Google Scholar 

  • Morgenstern C, Biermann E (1997) Ginkgo special extract (EGb 761®) in the treatment of tinnitus aurium – results of a randomized, double-blind, placebo-controlled study (in German). Fortschr Med Orig 115:7–11

    Google Scholar 

  • Morgenstern C, Biermann E (2002) The efficacy of Ginkgo special extract EGb 761® in patients with tinnitus. Int J Clin Pharmacol Ther 40:188–197

    PubMed  CAS  Google Scholar 

  • Müller WE, Abdel-Kader RM, Fehske CJ, Leuner K (2009) Grundlagen der therapeutischen Anwendung von EGb 761® (R). Wirkung auf die Kraftwerke der Zellen. Pharm Unserer Zeit 38:408–416

    PubMed  Google Scholar 

  • Mußgnug G, Alemany J (1968) Studies on disorders of peripheral arterial circulation. Part XV: problems of conservative therapy of obliterating disorders of peripheral circulation demonstrated on tincture and extract of Ginkgo biloba (in German). Arzneimittelforschung 18:453–550

    Google Scholar 

  • Myers S (2007) The complexities of botanical quality, natural products insider, http://www.naturalproductsinsider.com. Accessed 05 July 2011, Article not accessible)

  • Napryeyenko O, Borzenko I, for the GINDEM-NP Study Group (2007) Ginkgo biloba special extract in dementia with neuropsychiatric features – a randomized, placebo-controlled, double-blind clinical trial. Arzneimittelforschung 57:4–11

    PubMed  CAS  Google Scholar 

  • Neuropathology Group of the Medical Research Council Cognitive Function and Ageing Study (2001) Pathological correlates of late-onset dementia in a multicentre, community-based population in England and Wales. Lancet 357:169–175

    Google Scholar 

  • Niizuma K, Yoshioka H, Chen H, Kim GS, Jung JE, Katsu M, Okami N, Chan PH (2010) Mitochondrial and apoptotic neuronal death signaling pathways in cerebral ischemia. Biochim Biophys Acta 1802:92–9

    PubMed  CAS  Google Scholar 

  • Noeldner M, Chatterjee SS (1994) Anxiolytic-like activity of bilobalide [Abstr. 388]. Naunyn Schmiedeberg’s Arch Pharmacol 349(suppl):R97

    Google Scholar 

  • Oberpichler-Schwenk H, Beck T, Abdel-Rahman MM, Bielenberg GW, Krieglstein J (1988) Effects of Ginkgo biloba constituents related to protection against brain damage caused by hypoxia. Pharmacol Res Commun 20:349–368

    Google Scholar 

  • Otani M, Chatterjee SS, Gabard BL, Kreutzberg GW (1986) Effect of an extract of Ginkgo biloba on Triethyltin-induced cerebral edema. Acta Neuropathol 69:54–65

    PubMed  CAS  Google Scholar 

  • Pardon MC, Joubert C, Perez-Diaz F, Christen Y, Launay JM, Cohen-Salmon C (2000) In vivo regulation of cerebral monoamine oxidase activity in senescent controls and chronically stressed mice by long-term treatment with Ginkgo biloba extract (EGb 761®). Mech Ageing Dev 113:157–68

    PubMed  CAS  Google Scholar 

  • Peter H, Fisel J, Weisser W (1966) Zur Pharmakologie der Wirkstoffe aus Ginkgo biloba. Arzneimittelforschung 16:719–25

    PubMed  CAS  Google Scholar 

  • Pietta PG, Gardana C, Mauri PL, Maffei FR, Carini M (1995) Identification of flavonoid metabolites after oral administration to rats of a Ginkgo biloba extract. J Chromatogr B Biomed Appl 673(1):75–80

    PubMed  CAS  Google Scholar 

  • Pincemail J, Deby C (1986) The antiradical properties of Ginkgo biloba extract. Presse Med 15(31):1475–1479

    PubMed  CAS  Google Scholar 

  • Porsolt RD, Martin P, Lenegre A, Fromage S, Drieu K (1990) Effects of an extract of Ginkgo biloba (EGb 761® [TANAKAN]) on “learned helplessness” and other models of stress in rodents. Pharmacol Biochem Behav 36:963–971

    PubMed  CAS  Google Scholar 

  • Rangel-Ordóñez L, Noeldner M, Schubert-Zsilavecz M, Wurglics M (2010) Plasma levels and distribution of flavonoids in rat brain after single and repeated doses of standardized Ginkgo biloba extract EGb 761® (R). Planta Med 76(15):1683–1690

    PubMed  Google Scholar 

  • Rickard NS, Kowadlo N, Gibbs ME (2001) Effect of the Ginkgo biloba extract, EGb 761®, on memory formation in day-old chicks. Pharmacol Biochem Behav 69:351–358

    PubMed  CAS  Google Scholar 

  • Rimbach G, Cermak R, Wolffram S (2004) Gene regulatory activity of Ginkgo biloba L. (Chap. 5). In: Bao Y, Fenwick R (eds) Phytochemicals in health and disease. Marcel Dekker, New York, pp 105–119

    Google Scholar 

  • Rojas P, Rojas-Castañeda J, Vigueras RM, Rojas C (2000) Ginkgo biloba pretreatment partially protects from the dopaminergic neurotoxicity of 1-methyl-4-phenylpyridinium. Proc West Pharmacol Soc 43:87–8

    PubMed  CAS  Google Scholar 

  • Rojas P, Garduño B, Rojas C, Vigueras RM, Rojas-Castañeda J, Rios C, Serrano-Garcia N (2001) EGb761 blocks MPP+-induced lipid peroxidation in mouse corpus striatum. Neurochem Res 26:1245–51

    PubMed  CAS  Google Scholar 

  • Rojas P, Serrano-García N, Mares-Sámano JJ, Medina-Campos ON, Pedraza-Chaverri J, Ogren SO (2008) EGb761 protects against nigrostriatal dopaminergic neurotoxicity in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinsonism in mice: role of oxidative stress. Eur J Neurosci 28:41–50

    PubMed  Google Scholar 

  • Sakakibara H, Ishida K, Grundmann O, Nakajima JI, Seo S, Butterweck V, Minami Y, Saito S, Kawai Y, Nakaya Y, Terao J (2006) Antidepressant effect of extracts from Ginkgo biloba leaves in behavioral models. Biol Pharm Bull 29:1767–1770

    PubMed  CAS  Google Scholar 

  • Saleem S, Zhuang H, Biswal S, Christen Y, Dore S (2008) Ginkgo Biloba extract neuroprotective action is dependent on heme oxygenase 1 in ischemic reperfusion brain injury. Stroke 39:3389–3396

    PubMed  Google Scholar 

  • Sanceario G, Kreutzberg GW (1986) Stimulation of astrocytes affects cytotoxic brain edema. Acta Neuropathol 72:3–14

    Google Scholar 

  • Saponaro A, Gambelli G, Cosentino F (1971) First results from a clinical and instrumental investigation of the effects of a new phytotherapeutic substance on the cerebral and peripheral arterial circulation (in Italian). Minerva Med 62:4838–4849

    PubMed  CAS  Google Scholar 

  • Schennen A (1988) Neue Inhaltsstoffe aus den Blaettern von Ginkgo biloba. l. sowie Praeparation 14c-markierter Ginkgo-flavonoidepharm Biol. Dissertation, Univ. Marburg

    Google Scholar 

  • Schindowski K, Leutner S, Kressmann S, Eckert A, Mueller WE (2001) Age-related increase of oxidative stress-induced apoptosis in mice: prevention by Ginkgo biloba extract (EGb 761®). J Neural Transm 108:969–978

    PubMed  CAS  Google Scholar 

  • Schneider LS, DeKosky ST, Farlow MR, Tariot PN, Hoerr R, Kieser M (2005) A randomized, double-blind, placebo-controlled trial of two doses of Ginkgo biloba extract in dementia of the Alzheimer’s type. Curr Alzheimer Res 2:541–551

    PubMed  CAS  Google Scholar 

  • Schneider JA, Arvanitakis Z, Bang W, Bennett DA (2007) Mixed brain pathologies account for most dementia cases in community-dwelling older persons. Neurology 69:2197–2204

    PubMed  Google Scholar 

  • Scholtyssek H, Damerau W, Wessel R, Schimke I (1997) Antioxidative activity of ginkgolides against superoxide in an aprotic environment. Chem Biol Interact 106:183–190

    PubMed  CAS  Google Scholar 

  • Schötz K (2002) Detection of allergenic urushiols in Ginkgo biloba leaves. Pharmazie 57(7):508–510

    Google Scholar 

  • Shah ZA, Nada SE, Doré S (2011) Heme oxygenase 1, beneficial role in permanent ischemic stroke and in Gingko biloba (EGb 761®) neuroprotection. Neuroscience 180:248–255

    PubMed  CAS  Google Scholar 

  • Shen J, Lee W, Gu Y, Tong Y, Fung PC, Tong L (2011) Ginkgo biloba extract EGb 761®) inhibits mitochondria-dependent caspase pathway and prevents apoptosis in hypoxia-reoxygenated cardiomyocytes. Chin Med 6:8

    PubMed  CAS  Google Scholar 

  • Shi C, Wu F, Yew DT, Xu J, Zhu Y (2010) Bilobalide prevents apoptosis through activation of the PI3K/Akt pathway in SH-SY5Y cells. Apoptosis 15:715–727

    PubMed  CAS  Google Scholar 

  • Smith JV, Burdick AJ, Golik P, Khan I, Wallace D, Luo Y (2002) Anti-apoptotic properties of Ginkgo biloba extract EGb 761® in differentiated PC12 cells. Cell Mol Biol 48:699–707

    PubMed  CAS  Google Scholar 

  • Snowdon DA, Greiner LH, Mortimer JA, Riley KP, Greiner PA, Markesbery WR (1997) Brain infarction and the clinical expression of Alzheimer disease – The Nun Study. JAMA 277:813–817

    PubMed  CAS  Google Scholar 

  • Soulie C, Nicole A, Christen Y, Ceballos-Picot I (2002) The Ginkgo biloba extract EGb 761® increases viability of hnt human neurons in culture and affects the expression of genes implicated in the stress response. Cell Mol Biol 48:641–646

    PubMed  CAS  Google Scholar 

  • Spiess E, Juretzek W (2004) Hagers Handbuch der Pharmazeutischen Praxis, CD-Ausg. Hager ROM, Springer, Berlin, Heidelberg Ginkgo biloba, HN 2032700

    Google Scholar 

  • Sram RJ, Binkova B (1993) Side-effects of psychotropic therapy. In: Packer L, Prilipko L, Christen Y (eds) Free radicals in the brain – aging, neurological and mental disorders; Joint Meeting World Health Organization (WHO), Found. IPSEN. Springer, Berlin, pp 153–166

    Google Scholar 

  • Stackman RW, Eckenstein F, Frei B, Kulhanek D, Nowlin J, Quinn JF (2003) Prevention of age-related spatial memory deficits in a transgenic mouse model of Alzheimer’s disease by chronic Ginkgo biloba treatment. Exp Neurol 184:510–20

    PubMed  Google Scholar 

  • Sticher O (1992) Ginkgo biloba – Analytik und Zubereitungsformen. Pharm Unserer Zeit 21(6):253–265

    PubMed  CAS  Google Scholar 

  • Stoll S, Scheuer K, Pohl O, Mueller WE (1996) Ginkgo biloba extract (EGb-761) independently improves changes in passive avoidance learning and brain membrane fluidity in the aging mouse. Pharmacopsychiatry 29:144–149

    PubMed  CAS  Google Scholar 

  • Su SY, Hsieh CL, Wu SL, Cheng WY, Li CC, Lo HY, Ho TY, Hsiang CY (2009) Transcriptomic analysis of EGb 761®-regulated neuroactive receptor pathway in vivo. J Ethnopharmacol 123:68–73

    PubMed  CAS  Google Scholar 

  • Taillandier J, Ammar A, Rabourdin JP, Ribeyre JP, Pichon J, Niddam S, Pierart H (1986) Ginkgo biloba extract in the treatment of cerebral disorders due to ageing – a longitudinal, multicentric, double-blind, drug versus placebo trial (in French). Presse Med 15:1583–1587

    PubMed  CAS  Google Scholar 

  • Tawab M, Krzywon M, Schubert-Zsilavecz M (2010) Nahrungsergänzungs-mittel mit Ginkgo unter der Lupe. Pharm Ztg 155(20):1994–1999

    Google Scholar 

  • Tchantchou F, Xu Y, Wu Y, Christen Y, Luo Y (2007) EGb 761® enhances adult hippocampal neurogenesis and phosphorylation of CREB in transgenic mouse model of Alzheimer’s disease. FASEB J 21:2400–2408

    PubMed  CAS  Google Scholar 

  • Tendi EA, Bosetti F, Dasgupta SF, Stella AM, Drieu K, Rapoport SI (2002) Ginkgo biloba extracts EGb 761® and bilobalide increase NADH dehydrogenase mRNA level and mitochondrial respiratory control ratio in PC12 cells. Neurochem Res 27:319–323

    PubMed  CAS  Google Scholar 

  • Ude C, Paulke A, Noeldner M, Schubert-Zsilavecz M, Wurglics M (2011) Plasma and brain levels of terpene trilactones in rats after an oral single dose of standardized Ginkgo biloba extract EGb 761® (R). Planta Med 77(3):259–264

    PubMed  CAS  Google Scholar 

  • Upton R, (2003) Ginkgo leaf Ginkgo leaf dry extract Ginkog biloba L: standards of analysis, quality control and therapeutics. American Herbal Pharmacopoeia and Therapeutic Compendium, Santa Cruz, CA, USA

    Google Scholar 

  • Uríková A, Babusíková E, Dobrota D, Drgová A, Kaplán P, Tatarková Z, Lehotský J (2006) Impact of Ginkgo biloba Extract EGb 761® on ischemia/reperfusion-induced oxidative stress products formation in rat forebrain. Cell Mol Neurobiol 26:1343–53

    PubMed  Google Scholar 

  • van Beek TA (ed) (2000) Ginkgo biloba. Harwood Academic Publishers, Amsterdam

    Google Scholar 

  • van Beek TA, Montoro P (2009) Chemical analysis and Quality control of Ginkgo biloba leaves, extracts and phytopharmaceuticals. J Chromatogr A 1216(11):2002–2032

    Google Scholar 

  • Vellas B, Coley N, Ousset PJ, Berrut G, Dartigues JF, Dubois B, Grandjean H, Pasquier F, Piette F, Robert P, Touchon J, Garnier P, Mathiex-Fortunet H, Andrieu S, for the GuidAge Study Group (2010) Results of GuidAge – a 5-year placebo-controlled study of the efficacy of EGb 761® 120 mg to prevent or delay Alzheimer’s dementia onset in elderly subjects with memory complaint. J Nutr Health Aging 14(suppl 2):S23

    Google Scholar 

  • Walesiuk A, Trofimiuk E, Braszko JJ (2005) Gingko biloba extract diminishes stress-induced memory deficits in rats. Pharmacol Rep 57:176–87

    PubMed  Google Scholar 

  • Watanabe CMH, Wolffram S, Ader P, Rimbach G, Packer L, Maguire JJ, Schultz PG, Gohil K (2001) The in vivo neuromodulatory effects of the herbal medicine Ginkgo biloba. Proc Natl Acad Sci USA 98:6577–6580

    PubMed  CAS  Google Scholar 

  • Wang BS, Wang H, Song YY, Qi H, Rong ZX, Wang BS, Zhang L, Chen HZ (2010) Effectiveness of standardized Ginkgo biloba extract on cognitive symptoms of dementia with a six-month treqatment: a bivariate random effect meta-analysis. Pharmacopsychiatry 43:86–91

    Google Scholar 

  • Weichel O, Hilgert M, Chatterjee SS, Lehr M, Klein J (1999) Bilobalide, a constituent of Ginkgo biloba, inhibits NMDA-induced phospholipase A2 activation and phospholipid breakdown in rat hippocampus. Naunyn Schmiedebergs Arch Pharmacol 360:609–15

    PubMed  CAS  Google Scholar 

  • Weinmann S, Roll S, Schwarzbach C (2010) Effects of Ginkgo biloba in dementia: systematic review and meta-analysis. BMC Geriatr 10(14)

    Google Scholar 

  • Weitbrecht WU, Jansen W (1986) Ginkgo biloba extract in the treatment of primary degenerative dementia – placebo-controlled, double-blind and comparative study (in German). Fortschr Med 104:199–202

    PubMed  CAS  Google Scholar 

  • Wesnes K, Simmons D, Rook M, Simpson P (1987) A double-blind placebo-controlled trial of Tanakan in the treatment of idiopathic cognitive impairment in the elderly. Hum Psychopharmacol 2:159–169

    Google Scholar 

  • Wilson RS, Leurgans SE, Boyle PA, Schneider JA, Bennett DA (2010) Neurodegenerative basis of age-related cognitive decline. Neurology 75:1070–1078

    PubMed  CAS  Google Scholar 

  • Winter E (1991) Effects of an extract of Ginkgo biloba on learning and memory in mice. Pharmacol Biochem Behav 38:109–14

    PubMed  CAS  Google Scholar 

  • Winter JC (1998) The effects of an extract of Ginkgo biloba, EGb 761®, on cognitive behavior and longevity in the rat. Physiol Behav 63:425–33

    PubMed  CAS  Google Scholar 

  • Wirth S, Stemmelin J, Will B, Christen Y, Di Scala G (2000) Facilitative effects of EGb 761® on olfactory recognition in young and aged rats. Pharmacol Biochem Behav 65:321–6

    PubMed  CAS  Google Scholar 

  • Wu Y, Wu Z, Butko P, Christen Y, Lambert MP, Klein WL, Link CD, Luo Y (2006) Amyloid-beta-induced pathological behaviors are suppressed by Ginkgo biloba extract EGb 761® and ginkgolides in transgenic Caenorhabditis elegans. J Neurosci 26:13102–13113

    PubMed  CAS  Google Scholar 

  • Yan FL, Zheng Y, Zhao FD (2008) Effects of Ginkgo biloba extract EGb-761 on expression of RAGE and LRP-1 in cerebral microvascular endothelial cells under chronic hypoxia and hypoglycemia. Acta Neuropathol 116:529–535

    PubMed  Google Scholar 

  • Yeh YC, Liu TJ, Wang LC, Lee HW, Ting CT, Lee WL, Hung CJ, Wang KY, Lai HC, Lai HC (2009) A standardized extract of Ginkgo biloba suppresses doxorubicin-induced oxidative stress and p53-mediated mitochondrial apoptosis in rat testes. Br J Pharmacol 156:48–61

    PubMed  CAS  Google Scholar 

  • Yoshitake T, Yoshitake S, Kehr J (2010) The Ginkgo biloba extract EGb 761® and its main constituent flavonoids and ginkgolides increase extracellular dopamine levels in the rat prefrontal cortex. Br J Pharmacol 159:659–68

    PubMed  CAS  Google Scholar 

  • Zhuang H, Pin S, Christen Y, Dore S (2002) Induction of heme oxygenase 1 by Ginkgo biloba in neuronal cultures and potential implications in ischemia. Cell Mol Biol 48:647–653

    PubMed  CAS  Google Scholar 

  • Zou W, Kim BO, Zhou BY, Liu Y, Messing A, He JJ (2007) Protection against human immunodeficiency virus type 1 Tat neurotoxicity by Ginkgo biloba extract EGb 761® involving glial fibrillary acidic protein. Am J Pathol 171:1923–35

    PubMed  CAS  Google Scholar 

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Lang, F., Hoerr, R., Noeldner, M., Koch, E. (2013). Ginkgo biloba Extract EGb 761®: From an Ancient Asian Plant to a Modern European Herbal Medicinal Product. In: Wagner, H., Ulrich-Merzenich, G. (eds) Evidence and Rational Based Research on Chinese Drugs. Springer, Vienna. https://doi.org/10.1007/978-3-7091-0442-2_11

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