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Messenger RNA Vaccines

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Gene Vaccines

Abstract

Twenty years after the seminal observation of Wolff et al. that injection of naked RNA and DNA vectors results in protein expression in vivo, messenger RNA (mRNA) vaccines have found entry into clinical development. Through improved vector design, formulation, and delivery, mRNA, initially perceived as unstable and difficult to manipulate, has been developed into a convenient, efficacious, and flexible vaccine platform. Importantly, the same production process can be used to produce a variety of different vaccines, independent of the specifics of particular constructs, which ultimately decreases costs and development time.

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Authors and Affiliations

  1. CureVac GmbH, Tübingen, Germany

    Jochen Probst, Mariola Fotin-Mleczek, Thomas Schlake, Andreas Thess, Thomas Kramps & Karl-Josef Kallen

Authors
  1. Jochen Probst
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  2. Mariola Fotin-Mleczek
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  3. Thomas Schlake
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  4. Andreas Thess
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  5. Thomas Kramps
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  6. Karl-Josef Kallen
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Correspondence to Jochen Probst .

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Editors and Affiliations

  1. , Department of Molecular Biology, University of Salzburg, Hellbrunnerstrasse 34, Salzburg, 5020, Austria

    Josef Thalhamer

  2. , Department of Molecular Biology, University of Salzburg, Hellbrunnerstrasse 34, Salzburg, 5020, Austria

    Richard Weiss

  3. , Department of Molecular Biology, University of Salzburg, Hellbrunnerstrasse 34, Salzburg, 5020, Austria

    Sandra Scheiblhofer

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Probst, J., Fotin-Mleczek, M., Schlake, T., Thess, A., Kramps, T., Kallen, KJ. (2012). Messenger RNA Vaccines. In: Thalhamer, J., Weiss, R., Scheiblhofer, S. (eds) Gene Vaccines. Springer, Vienna. https://doi.org/10.1007/978-3-7091-0439-2_11

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