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Bioceramics in Tissue Engineering

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Biomaterials for Tissue Engineering Applications

Abstract

This chapter is focused on the classification of bioceramics and their medical applications. Alumina, zirconia or alumina–zirconia-based composite bioinert ceramics are currently used as femoral heads, acetabular cups for hip replacement, and dental implants. Nano-structured bioinert ceramics with significantly improved toughness and stability are desirable for future clinical needs. Bioactive glass and calcium phosphates are being investigated as bone fillers, bone cements, coatings, and scaffolds for bone repair and regeneration. Cell-laden biodegradable bioceramic/biopolymer hybrid composites mimicking the bony hierarchical structure present the desired properties for bone substitution and tissue engineering and are creating a new generation of regeneration materials. Bioceramics for dental and cancer treatment are also introduced in this chapter. Further challenges in bioceramic scaffold fabrication for tissue engineering are also discussed.

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Acknowledgments

We would like to acknowledge the grant support from the Wallace H. Coulter Foundation, the March of Dimes Birth Defect Foundation, the Airlift Research Foundation, DOD W81XWH-10-1-0966, and NIH R01AR057837.

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Authors and Affiliations

  1. Houston Biomaterials Research Center, Department of Restorative Dentistry and Biomaterials, University of Texas Health Science Center at Houston, 6516 M.D. Anderson Blvd., D 4.133, Houston, TX, 77030, USA

    Yunzhi Yang

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  1. Yunzhi Yang
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  2. Yunqing Kang
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  3. Milan Sen
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  4. Sangwon Park
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Correspondence to Yunzhi Yang .

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  1. Dept. of Bioengineering, University of Pennsylvania, 210 S. 33rd Street, 240 Skirkanich Hall, 19104-6321, Philadelphia, Pennsylvania, USA

    Jason A. Burdick

  2. Dept. of Orthopaedic Surgery McKay Orthopaedic Research Laboratory, University of Pennsylvania, 36th Street and Hamilton Walk, 19104, Philadelphia, Pennsylvania, USA

    Robert L. Mauck

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Yang, Y., Kang, Y., Sen, M., Park, S. (2011). Bioceramics in Tissue Engineering. In: Burdick, J.A., Mauck, R.L. (eds) Biomaterials for Tissue Engineering Applications. Springer, Vienna. https://doi.org/10.1007/978-3-7091-0385-2_7

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