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Tumor Microenvironment for Melanoma Cells

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Melanoma Development

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Abstract

Melanoma represents an ideal experimental system to model the influence of tumor microenvironment on neoplastic cells given that a rich collection of cell types is localized in the physiological environment. Melanoma cells actively interact with the tumor microenvironment in a bidirectional manner by orchestrating the normal cells. Human epidermal melanocytes can readily be isolated and used as a paradigm to ­understand initiation and development of their malignant counterparts, melanoma cells. This chapter focuses on cell–cell communication between melanocytes and surrounding keratinocytes and fibroblasts, and summarizes key growth factors and inflammatory cytokines that are important for melanocyte function and homeostasis. We will then ­propose a model of malignant transformation of melanocytes, in which microenvironmental signals play key roles.

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Authors and Affiliations

  1. Molecular and Cellular Oncogenesis Program, The Wistar Institute Melanoma Research Center, The Wistar Institute, 3601 Spruce Street, Philadelphia, PA, 19104, USA

    Meenhard Herlyn

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  1. Gao Zhang
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  2. Meenhard Herlyn
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Correspondence to Meenhard Herlyn .

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Editors and Affiliations

  1. , Molecular Pathology, Institute of Pathololgy, Franz-Josef-Strauss-Allee 11, Regensburg, 93053, Germany

    Anja Bosserhoff

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Zhang, G., Herlyn, M. (2011). Tumor Microenvironment for Melanoma Cells. In: Bosserhoff, A. (eds) Melanoma Development. Springer, Vienna. https://doi.org/10.1007/978-3-7091-0371-5_14

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