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Early Brain Injury or Cerebral Vasospasm pp 9–11Cite as

Mechanisms of Statin Treatment in Cerebral Vasospasm

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Part of the book series: Acta Neurochirurgica Supplements ((NEUROCHIRURGICA,volume 110/2))

Abstract

3-Hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase inhibitors, commonly known as statins, are widely used clinically for their lipid lowering properties. Recent experimental evidence shows that statins are also effective in ameliorating cerebral vasospasm, which occurs as sequelae of subarachnoid hemorrhage. This literature review focuses on the literature-based putative mechanisms involved in statin mediated attenuation of cerebral vasospasm, such as eNOS, vascular inflammation, apoptosis, especially the phosphatidylinositol 3-kinase/Akt (PI3K/Akt) pathway from our experimental study.

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Author information

Authors and Affiliations

  1. Department of Physiology and Pharmacology, Loma Linda University, Loma Linda, CA, USA

    Takashi Sugawara, Robert Ayer, Vikram Jadhav, Wanqiu Chen, Tamiji Tsubokawa & John H. Zhang

  2. Department of Neurosurgery, Loma Linda University Medical Center, 11234 Anderson Street, Room 2562B, Loma Linda, CA, 92354, USA

    John H. Zhang

  3. Department of Anesthesiology, Loma Linda University, Loma Linda, CA, USA

    John H. Zhang

  4. Department of Neurosurgery, National Hospital Organization Disaster Medical Center, Tokyo, Japan

    Takashi Sugawara

Authors
  1. Takashi Sugawara
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  2. Robert Ayer
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  3. Vikram Jadhav
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  4. Wanqiu Chen
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  5. Tamiji Tsubokawa
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  6. John H. Zhang
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Corresponding author

Correspondence to John H. Zhang .

Editor information

Editors and Affiliations

  1. Department of Neurosurgery, Southwest Hospital, Third Military Medical University, Gaotanyan 30, Chongqing, 400038, China

    Hua Feng

  2. Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China

    Ying Mao

  3. Departments of Physiology and Neurosurgery, Loma Linda University School of Medicine, Risley Hall, Room 223, 92354, Loma Linda, California, USA

    John H. Zhang

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© 2011 Springer-Verlag/Wien

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Cite this paper

Sugawara, T., Ayer, R., Jadhav, V., Chen, W., Tsubokawa, T., Zhang, J.H. (2011). Mechanisms of Statin Treatment in Cerebral Vasospasm. In: Feng, H., Mao, Y., Zhang, J.H. (eds) Early Brain Injury or Cerebral Vasospasm. Acta Neurochirurgica Supplements, vol 110/2. Springer, Vienna. https://doi.org/10.1007/978-3-7091-0356-2_2

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  • DOI: https://doi.org/10.1007/978-3-7091-0356-2_2

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-7091-0355-5

  • Online ISBN: 978-3-7091-0356-2

  • eBook Packages: MedicineMedicine (R0)

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