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Mitogen-Activated Protein Kinases in Cerebral Vasospasm After Subarachnoid Hemorrhage: A Review

  • Conference paper
Early Brain Injury or Cerebral Vasospasm

Part of the book series: Acta Neurochirurgica Supplements ((NEUROCHIRURGICA,volume 110/1))

Abstract

Background: Mitogen-activated protein kinases (MAPKs) have been implicated in the pathogenesis of cerebral vasospasm after subarachnoid hemorrhage. The goal of this review is to bring together recent diverse data concerning the roles of MAPKs in cerebral vasospasm and to consider the future research. Emphasis Type="Italic">Method: A review of publications in the National Library of Medicine and National Institutes of Health database was conducted in August 2009 using specific keyword search terms pertaining to subarachnoid hemorrhage and MAPKs. Findings: There are nine in vitro studies and 17 in vivo studies published. Most of previous studies used MAPK inhibitors or their upstream molecule inhibitors, and showed that MAPK inhibitions prevented vasospasm. The MAPK cascade appears to interact with other signaling molecules, and MAPK may be an important final common pathway for the signaling transduction during cerebral vasospasm. However, the mechanism by which MAPK causes sustained vascular smooth muscle contraction remains unclear. In addition, the role of endogenous MAPK inhibitors, MAPK phosphatases, has not been investigated in cerebral vasospasm. Conclusions: The experimental data support the causative role of MAPK in cerebral vasospasm and warrant further research.

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Acknowledgments

This study was partially supported by grants (NS053407) from the National Institutes of Health to J.H.Z.

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Authors and Affiliations

  1. Department of Physiology, Loma Linda University School of Medicine, Risley Hall, Room 223, Loma Linda, CA, 92354, USA

    Hidenori Suzuki, Yu Hasegawa & John H. Zhang

  2. Department of Neurosurgery, Suzuka Kaisei Hospital, Suzuka, Japan

    Kenji Kanamaru

  3. Department of Neurosurgery, Loma Linda University School of Medicine, Risley Hall, Room 223, Loma Linda, CA, 92354, USA

    John H. Zhang

Authors
  1. Hidenori Suzuki
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  4. John H. Zhang
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Correspondence to John H. Zhang .

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Editors and Affiliations

  1. Department of Neurosurgery, Southwest Hospital, Third Military Medical University, Gaotanyan 30, Chongqing, 400038, China

    H.-J. Steiger  & Hua Feng  & 

  2. Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China

    Ying Mao

  3. Departments of Physiology and Neurosurgery, Loma Linda University School of Medicine, Risley Hall, Room 223, 92354, Loma Linda, California, USA

    John H. Zhang

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Suzuki, H., Hasegawa, Y., Kanamaru, K., Zhang, J.H. (2011). Mitogen-Activated Protein Kinases in Cerebral Vasospasm After Subarachnoid Hemorrhage: A Review. In: Feng, H., Mao, Y., Zhang, J.H. (eds) Early Brain Injury or Cerebral Vasospasm. Acta Neurochirurgica Supplements, vol 110/1. Springer, Vienna. https://doi.org/10.1007/978-3-7091-0353-1_23

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  • DOI: https://doi.org/10.1007/978-3-7091-0353-1_23

  • Publisher Name: Springer, Vienna

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