New Regulatory, Signaling Pathways, and Sources of Nitric Oxide
Discovered in 1980 by the late Robert F. Furchgott, endothelium-derived relaxing factor, nitric oxide (NO), has been in the forefront of vascular research for several decades. What was originally a narrow approach, has been significantly widened due to major advances in understanding the chemical and biological properties of NO as well as its signaling pathways and discovering new sources of this notorious free radical gas. In this review, recent discoveries regarding NO and their implications on therapy for delayed cerebral vasospasm are presented.
KeywordsHemoglobin Neuroglobin Nitric oxide SAH Vasospasm
This research was supported by the Intramural Research Program of the National Institute of Neurological Disorders and Stroke at the NIH.
Conflict of interest statement
The author is one of holders of the international patent on sodium nitrite use in cerebrovascular diseases.
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