Skip to main content
SpringerLink
Log in

Immunological Response in Early Brain Injury After SAH

  • Conference paper
Book cover Early Brain Injury or Cerebral Vasospasm

Part of the book series: Acta Neurochirurgica Supplements ((NEUROCHIRURGICA,volume 110/1))

Abstract

This study summarized the role of inflammation in the early brain injury after subarachnoid hemorrhage. Elevation of cytokines, activation of MMPs and phosphorylation of MAPK contributes to neuronal apoptosis and brain edema. Anti-inflammation may be potential strategy for the prevention and suppression of early brain injury after subarachnoid hemorrhage.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Broderick JP, Brott T, Tomsick T, Miller R, Huster G. Intracerebral hemorrhage more than twice as common as subarachnoid hemorrhage. J Neurosurg. 1993;78:188–91.

    Article  PubMed  CAS  Google Scholar 

  2. Schievink WI, Riedinger M, Jhutty TK, Simon P. Racial disparities in subarachnoid hemorrhage mortality: Los Angeles County, California, 1985–1998. Neuroepidemiology 2004;23:299–305.

    Google Scholar 

  3. Hütter BO, Kreitschmann-Andermahr I, Gilsbach JM. Health-related quality of life after aneurysmal subarachnoid hemorrhage: impacts of bleeding severity, computerized tomography findings, surgery, vasospasm, and neurological grade. J Neurosurg. 2001;94:241–51.

    Article  PubMed  Google Scholar 

  4. Cahill J, Calvert JW, Zhang JH. Mechanisms of early brain injury after subarachnoid hemorrhage. J Cereb Blood Flow Metab. 2006;26:1341–53.

    Article  PubMed  CAS  Google Scholar 

  5. Ostrowski RP, Colohan AR, Zhang JH. Molecular mechanisms of early brain injury after subarachnoid hemorrhage. Neurol Res. 2006;28:399–414.

    Article  PubMed  CAS  Google Scholar 

  6. Sercombe R, Dinh YR, Gomis P. Cerebrovascular inflammation following subarachnoid hemorrhage. Jpn J Pharmacol. 2002;88:227–49.

    Article  PubMed  CAS  Google Scholar 

  7. McKeating EG, Andrews PJ. Cytokines and adhesion molecules in acute brain injury. Br J Anaesth. 1998;80:77–84.

    Article  PubMed  CAS  Google Scholar 

  8. Mathiesen T, Andersson B, Loftenius A, von Holst H. Increased interleukin-6 levels in cerebrospinal fluid following subarachnoid hemorrhage. J Neurosurg. 1993;78:562–7.

    Article  PubMed  CAS  Google Scholar 

  9. Gaetani P, Tartara F, Pignatti P, Tancioni F, Rodriguez y Baena R, De Benedetti F. Cisternal CSF levels of cytokines after subarachnoid hemorrhage. Neurol Res. 1998;20:337–42.

    PubMed  CAS  Google Scholar 

  10. Mathiesen T, Edner G, Ulfarsson E, Andersson B. Cerebrospinal fluid interleukin-1 receptor antagonist and tumor necrosis factor-alpha following subarachnoid hemorrhage. J Neurosurg. 1997;87:215–20.

    Article  PubMed  CAS  Google Scholar 

  11. Allan SM, Tyrrell PJ, Rothwell NJ. Interleukin-1 and neuronal injury. Nat Rev Immunol. 2005;5:629–40.

    Article  PubMed  CAS  Google Scholar 

  12. Prunell GF, Svendgaard NA, Alkass K, Mathiesen T. Inflammation in the brain after experimental subarachnoid hemorrhage. Neurosurgery 2005;56:1082–92.

    PubMed  Google Scholar 

  13. Kwon KY, Jeon BC. Cytokine levels in cerebrospinal fluid and delayed ischemic deficits in patients with aneurysmal subarachnoid hemorrhage. J Korean Med Sci. 2001;16:774–80.

    PubMed  CAS  Google Scholar 

  14. Wolburg H, Lippoldt A. Tight junctions of the blood–brain barrier: development, composition and regulation. Vascul Pharmacol. 2002;38:323–37.

    Article  PubMed  CAS  Google Scholar 

  15. Yang Y, Estrada EY, Thompson JF, Liu W, Rosenberg GA. Matrix metalloproteinase-mediated disruption of tight junction proteins in cerebral vessels is reversed by synthetic matrix metalloproteinase inhibitor in focal ischemia in rat. J Cereb Blood Flow Metab. 2007;27:697–709.

    Article  PubMed  CAS  Google Scholar 

  16. Yong VW, Power C, Forsyth P, Edwards DR. Metalloproteinases in biology and pathology of the nervous system. Nat Rev Neurosci. 2001;2:502–11.

    Article  PubMed  CAS  Google Scholar 

  17. Ruhul Amin AR, Senga T, Oo ML, Thant AA, Hamaguchi M. Secretion of matrix metalloproteinase-9 by the proinflammatory cytokine, IL-1beta: a role for the dual signaling pathways, Akt and Erk. Genes Cells. 2003;8:515–23.

    Article  PubMed  CAS  Google Scholar 

  18. Vecil GG, Larsen PH, Corley SM, Herx LM, Besson A, Goodyer CG, et al. Interleukin-1 is a key regulator of matrix metalloproteinase-9 expression in human neurons in culture and following mouse brain trauma in vivo. J Neurosci Res. 2000;61:212–24.

    Article  PubMed  CAS  Google Scholar 

  19. Guan Z, Buckman SY, Miller BW, Springer LD, Morrison AR. Interleukin-1beta-induced cyclooxygenase-2 expression requires activation of both c-Jun NH2-terminal kinase and p38 MAPK signal pathways in rat renal mesangial cells. J Biol Chem. 1998;273:28670–6.

    Article  PubMed  CAS  Google Scholar 

  20. Larsen CM, Wadt KA, Juhl LF, Andersen HU, Karlsen AE, Su MS, et al. Interleukin-1beta-induced rat pancreatic islet nitric oxide synthesis requires both the p38 and extracellular signal-regulated kinase 1/2 mitogen-activated protein kinases. J Biol Chem. 1998;273:15294–300.

    Article  PubMed  CAS  Google Scholar 

  21. Wu CY, Hsieh HL, Jou MJ, Yang CM. Involvement of p42/p44 MAPK, p38 MAPK, JNK and nuclear factor-kappa B in interleukin-1beta-induced matrix metalloproteinase-9 expression in rat brain astrocytes. J Neurochem. 2004;90:1477–88.

    Article  PubMed  CAS  Google Scholar 

Download references

Acknowledgments

This study was partially supported by grants (NS053407) from the National Institutes of Health to J.H.Z.

Author information

Authors and Affiliations

  1. Department of Neurosurgery, University of Occupational and Environmental Health, Japan 1-1, Iseigaoka, Yahata-nishi-ku, Kitakyushu, Fukuoka, 807-8555, Japan

    Takumi Sozen

  2. Department of Neurosurgery, University of Occupational and Environmental Health, Japan

    Takumi Sozen & Shigeru Nishizawa

  3. Department of Physiology, Loma Linda University of Medicine, Loma Linda, CA, 92350, USA

    Reiko Tsuchiyama, Yu Hasegawa, Hidenori Suzuki, Vikram Jadhav & John H. Zhang

  4. Department of Neurosurgery, Loma Linda University of Medicine, Loma Linda, CA, 92350, USA

    John H. Zhang

Authors
  1. Takumi Sozen
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Reiko Tsuchiyama
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Yu Hasegawa
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Hidenori Suzuki
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Vikram Jadhav
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Shigeru Nishizawa
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. John H. Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Takumi Sozen .

Editor information

Editors and Affiliations

  1. Department of Neurosurgery, Southwest Hospital, Third Military Medical University, Gaotanyan 30, Chongqing, 400038, China

    H.-J. Steiger  & Hua Feng  & 

  2. Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China

    Ying Mao

  3. Departments of Physiology and Neurosurgery, Loma Linda University School of Medicine, Risley Hall, Room 223, 92354, Loma Linda, California, USA

    John H. Zhang

Rights and permissions

Reprints and permissions

Copyright information

© 2011 Springer-Verlag/Wien

About this paper

Cite this paper

Sozen, T. et al. (2011). Immunological Response in Early Brain Injury After SAH. In: Feng, H., Mao, Y., Zhang, J.H. (eds) Early Brain Injury or Cerebral Vasospasm. Acta Neurochirurgica Supplements, vol 110/1. Springer, Vienna. https://doi.org/10.1007/978-3-7091-0353-1_10

Download citation

  • DOI: https://doi.org/10.1007/978-3-7091-0353-1_10

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-7091-0352-4

  • Online ISBN: 978-3-7091-0353-1

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation