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Immunity to Low-Density Lipoprotein

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Inflammation and Atherosclerosis

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Abstract

Animal experiments, epidemiological studies and clinical investigations all show that high levels of plasma low-density lipoprotein (LDL) promote atherosclerotic cardiovascular disease [1]. LDL particles contain epitopes that trigger cellular and humoral immune responses. Autoimmunization during the course of atherosclerosis generates proinflammatory T cell responses whereas vaccination with LDL components can lead to atheroprotective immunity. Mechanisms underlying these responses are discussed in the present review.

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References

  1. Hansson GK (2005) Inflammation, atherosclerosis, and coronary artery disease. N Engl J Med 352(16):1685–1695

    Article  PubMed  CAS  Google Scholar 

  2. Tabas I, Williams KJ, Boren J (2007) Subendothelial lipoprotein retention as the initiating process in atherosclerosis: update and therapeutic implications. Circulation 116(16):1832–1844

    Article  PubMed  CAS  Google Scholar 

  3. Skalen K, Gustafsson M, Rydberg EK, Hulten LM, Wiklund O, Innerarity TL, Boren J (2002) Subendothelial retention of atherogenic lipoproteins in early atherosclerosis. Nature 417(6890):750–754

    Article  PubMed  CAS  Google Scholar 

  4. Steinberg D (2009) The LDL modification hypothesis of atherogenesis: an update. J Lipid Res 50(Suppl):S376–S381

    Article  PubMed  Google Scholar 

  5. Navab M, Ananthramaiah GM, Reddy ST, Van Lenten BJ, Ansell BJ, Fonarow GC, Vahabzadeh K, Hama S, Hough G, Kamranpour N, Berliner JA, Lusis AJ, Fogelman AM (2004) The oxidation hypothesis of atherogenesis: the role of oxidized phospholipids and HDL. J Lipid Res 45(6):993–1007

    Article  PubMed  CAS  Google Scholar 

  6. Bochkov VN, Mechtcheriakova D, Lucerna M, Huber J, Malli R, Graier WF, Hofer E, Binder BR, Leitinger N (2002) Oxidized phospholipids stimulate tissue factor expression in human endothelial cells via activation of ERK/EGR-1 and Ca(++)/NFAT. Blood 99(1):199–206

    Article  PubMed  CAS  Google Scholar 

  7. Gharavi NM, Alva JA, Mouillesseaux KP, Lai C, Yeh M, Yeung W, Johnson J, Szeto WL, Hong L, Fishbein M, Wei L, Pfeffer LM, Berliner JA (2007) Role of the Jak/STAT pathway in the regulation of interleukin-8 transcription by oxidized phospholipids in vitro and in atherosclerosis in vivo. J Biol Chem 282(43):31460–31468

    Article  PubMed  CAS  Google Scholar 

  8. Gargalovic PS, Gharavi NM, Clark MJ, Pagnon J, Yang WP, He A, Truong A, Baruch-Oren T, Berliner JA, Kirchgessner TG, Lusis AJ (2006) The unfolded protein response is an important regulator of inflammatory genes in endothelial cells. Arterioscler Thromb Vasc Biol 26(11):2490–2496

    Article  PubMed  CAS  Google Scholar 

  9. Dai L, Zhang Z, Winyard PG, Gaffney K, Jones H, Blake DR, Morris CJ (1997) A modified form of low-density lipoprotein with increased electronegative charge is present in rheumatoid arthritis synovial fluid. Free Radic Biol Med 22(4):705–710

    Article  PubMed  CAS  Google Scholar 

  10. Frostegard J, Svenungsson E, Wu R, Gunnarsson I, Lundberg IE, Klareskog L, Horkko S, Witztum JL (2005) Lipid peroxidation is enhanced in patients with systemic lupus erythematosus and is associated with arterial and renal disease manifestations. Arthritis Rheum 52(1):192–200

    Article  PubMed  CAS  Google Scholar 

  11. Holvoet P, Perez G, Zhao Z, Brouwers E, Bernar H, Collen D (1995) Malondialdehyde-modified low density lipoprotein in patients with atherosclerotic disease. J Clin Invest 95:2611–2619

    Article  PubMed  CAS  Google Scholar 

  12. Miller YI, Choi SH, Wiesner P, Fang L, Harkewicz R, Hartvigsen K, Boullier A, Gonen A, Diehl CJ, Que X, Montano E, Shaw PX, Tsimikas S, Binder CJ, Witztum JL (2011) Oxidation-specific epitopes are danger-associated molecular patterns recognized by pattern recognition receptors of innate immunity. Circ Res 108(2):235–248

    Article  PubMed  CAS  Google Scholar 

  13. [a] Duewell P, Kono H, Rayner KJ, Sirois CM, Vladimer G, Bauernfeind FG, Abela GS, Franchi L, Nunez G, Schnurr M, Espevik T, Lien E, Fitzgerald KA, Rock KL, Moore KJ, Wright SD, Hornung V, Latz E (2010) NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals. Nature 464(7293):1357–1361; [b] Rajamaki K, Lappalainen J, Oorni K, Valimaki E, Matikainen S, Kovanen PT, Eklund KK (2010) Cholesterol crystals activate the nlrp3 inflammasome in human macrophages: A novel link between cholesterol metabolism and inflammation. PLoS ONE 5:e11765

    Article  PubMed  CAS  Google Scholar 

  14. Hansson GK, Hermansson A (2011) Immunity in atherosclerosis. Nat Immunol 12:204–212

    Article  PubMed  CAS  Google Scholar 

  15. Dansky HM, Charlton SA, Harper MM, Smith JD (1997) T and B lymphocytes play a minor role in atherosclerotic plaque formation in the apolipoprotein E-deficient mouse. Proc Natl Acad Sci USA 94:4642–4646

    Article  PubMed  CAS  Google Scholar 

  16. Reardon CA, Blachowicz L, White T, Cabana V, Wang Y, Lukens J, Bluestone J, Getz GS (2001) Effect of immune deficiency on lipoproteins and atherosclerosis in male apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol 21(6):1011–1016

    Article  PubMed  CAS  Google Scholar 

  17. Zhou X, Nicoletti A, Elhage R, Hansson GK (2000) Transfer of CD4(+) T cells aggravates atherosclerosis in immunodeficient apolipoprotein E knockout mice. Circulation 102(24):2919–2922

    PubMed  CAS  Google Scholar 

  18. Jonasson L, Holm J, Skalli O, Bondjers G, Hansson GK (1986) Regional accumulations of T cells, macrophages, and smooth muscle cells in the human atherosclerotic plaque. Arteriosclerosis 6(2):131–138

    Article  PubMed  CAS  Google Scholar 

  19. Jonasson L, Holm J, Skalli O, Gabbiani G, Hansson GK (1985) Expression of class II transplantation antigen on vascular smooth muscle cells in human atherosclerosis. J Clin Invest 76(1):125–131

    Article  PubMed  CAS  Google Scholar 

  20. Hansson GK, Holm J, Jonasson L (1989) Detection of activated T lymphocytes in the human atherosclerotic plaque. Am J Pathol 135(1):169–175

    PubMed  CAS  Google Scholar 

  21. Hansson GK, Robertson AKL, Söderberg-Nauclér C (2006) Inflammation and atherosclerosis. Annu Rev Pathol 1:297–329

    Article  PubMed  CAS  Google Scholar 

  22. Paulsson G, Zhou X, Tornquist E, Hansson GK (2000) Oligoclonal T cell expansions in atherosclerotic lesions of apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol 20(1):10–17

    Article  PubMed  CAS  Google Scholar 

  23. Liuzzo G, Goronzy JJ, Yang H, Kopecky SL, Holmes DR, Frye RL, Weyand CM (2000) Monoclonal T-cell proliferation and plaque instability in acute coronary syndromes. Circulation 101(25):2883–2888

    PubMed  CAS  Google Scholar 

  24. Olofsson PS, Soderstrom LA, Wagsater D, Sheikine Y, Ocaya P, Lang F, Rabu C, Chen L, Rudling M, Aukrust P, Hedin U, Paulsson-Berne G, Sirsjo A, Hansson GK (2008) CD137 is expressed in human atherosclerosis and promotes development of plaque inflammation in hypercholesterolemic mice. Circulation 117(10):1292–1301

    Article  PubMed  CAS  Google Scholar 

  25. Ludewig B, Freigang S, Jaggi M, Kurrer MO, Pei YC, Vlk L, Odermatt B, Zinkernagel RM, Hengartner H (2000) Linking immune-mediated arterial inflammation and cholesterol-induced atherosclerosis in a transgenic mouse model [In process citation]. Proc Natl Acad Sci USA 97(23):12752–12757

    Article  PubMed  CAS  Google Scholar 

  26. Gotsman I, Sharpe AH, Lichtman AH (2008) T-cell costimulation and coinhibition in atherosclerosis. Circ Res 103:1220–1231

    Article  PubMed  CAS  Google Scholar 

  27. Bobryshev YV, Lord RS (1995) S-100 positive cells in human arterial intima and in atherosclerotic lesions. Cardiovasc Res 29(5):689–696

    PubMed  CAS  Google Scholar 

  28. Angeli V, Llodra J, Rong JX, Satoh K, Ishii S, Shimizu T, Fisher EA, Randolph GJ (2004) Dyslipidemia associated with atherosclerotic disease systemically alters dendritic cell mobilization. Immunity 21(4):561–574

    Article  PubMed  CAS  Google Scholar 

  29. Niessner A, Sato K, Chaikof EL, Colmegna I, Goronzy JJ, Weyand CM (2006) Pathogen-sensing plasmacytoid dendritic cells stimulate cytotoxic T-cell function in the atherosclerotic plaque through interferon-alpha. Circulation 114(23):2482–2489

    Article  PubMed  CAS  Google Scholar 

  30. Choi JH, Do Y, Cheong C, Koh H, Boscardin SB, Oh YS, Bozzacco L, Trumpfheller C, Park CG, Steinman RM (2009) Identification of antigen-presenting dendritic cells in mouse aorta and cardiac valves. J Exp Med 206(3):497–505

    Article  PubMed  CAS  Google Scholar 

  31. Niessner A, Weyand CM (2010) Dendritic cells in atherosclerotic disease. Clin Immunol 134(1):25–32

    Article  PubMed  CAS  Google Scholar 

  32. Kovanen PT (2007) Mast cells: multipotent local effector cells in atherothrombosis. Immunol Rev 217:105–122

    Article  PubMed  CAS  Google Scholar 

  33. Grabner R, Lotzer K, Dopping S, Hildner M, Radke D, Beer M, Spanbroek R, Lippert B, Reardon CA, Getz GS, Fu YX, Hehlgans T, Mebius RE, van der Wall M, Kruspe D, Englert C, Lovas A, Hu D, Randolph GJ, Weih F, Habenicht AJ (2009) Lymphotoxin beta receptor signaling promotes tertiary lymphoid organogenesis in the aorta adventitia of aged ApoE−/− mice. J Exp Med 206(1):233–248

    Article  PubMed  Google Scholar 

  34. Caligiuri G, Nicoletti A, Poirier B, Hansson GK (2002) Protective immunity against atherosclerosis carried by B cells of hypercholesterolemic mice. J Clin Invest 109(6):745–753

    PubMed  CAS  Google Scholar 

  35. Major AS, Fazio S, Linton MF (2002) B-lymphocyte deficiency increases atherosclerosis in LDL receptor-null mice. Arterioscler Thromb Vasc Biol 22(11):1892–1898

    Article  PubMed  CAS  Google Scholar 

  36. Ait-Oufella H, Herbin O, Bouaziz JD, Binder CJ, Uyttenhove C, Laurans L, Taleb S, Van Vre E, Esposito B, Vilar J, Sirvent J, Van Snick J, Tedgui A, Tedder TF, Mallat Z (2010) B cell depletion reduces the development of atherosclerosis in mice. J Exp Med 207(8):1579–1587

    Article  PubMed  CAS  Google Scholar 

  37. Kyaw T, Tay C, Khan A, Dumouchel V, Cao A, To K, Kehry M, Dunn R, Agrotis A, Tipping P, Bobik A, Toh BH (2010) Conventional B2 B cell depletion ameliorates whereas its adoptive transfer aggravates atherosclerosis. J Immunol 185(7):4410–4419

    Article  PubMed  CAS  Google Scholar 

  38. Nicoletti A, Kaveri S, Caligiuri G, Bariety J, Hansson GK (1998) Immunoglobulin treatment reduces atherosclerosis in apo E knockout mice. J Clin Invest 102(5):910–918

    Article  PubMed  CAS  Google Scholar 

  39. Yuan Z, Kishimoto C, Sano H, Shioji K, Xu Y, Yokode M (2003) Immunoglobulin treatment suppresses atherosclerosis in apolipoprotein E-deficient mice via the Fc portion. Am J Physiol Heart Circ Physiol 285(2):H899–H906

    PubMed  CAS  Google Scholar 

  40. Okabe TA, Kishimoto C, Shimada K, Murayama T, Yokode M, Kita T (2005) Effects of late administration of immunoglobulin on experimental atherosclerosis in apolipoprotein E-deficient mice. Circ J 69(12):1543–1546

    Article  PubMed  CAS  Google Scholar 

  41. Keren G, Keren P, Barshack I, Pri-Chen S, George J (2001) The effect of intravenous immunoglobulins on intimal thickening in a mouse model of arterial injury. Atherosclerosis 159(1):77–83

    Article  PubMed  CAS  Google Scholar 

  42. Persson L, Boren J, Nicoletti A, Hansson GK, Pekna M (2005) Immunoglobulin treatment reduces atherosclerosis in apolipoprotein E−/− low-density lipoprotein receptor−/− mice via the complement system. Clin Exp Immunol 142(3):441–445

    PubMed  CAS  Google Scholar 

  43. Hansson GK, Holm J, Jonasson L (1989) Detection of activated T lymphocytes in the human atherosclerotic plaque. Am J Pathol 135(169):169–175

    PubMed  CAS  Google Scholar 

  44. Paulsson G, Zhou X, Törnquist E, Hansson GK (2000) Oligoclonal T cell expansions in atherosclerotic lesions of apoE-deficient mice. Arterioscler Thromb Vasc Biol 20:10–17

    Article  PubMed  CAS  Google Scholar 

  45. Hansson GK, Libby P (2006) The immune response in atherosclerosis: a double-edged sword. Nat Rev Immunol 6(7):508–519

    Article  PubMed  CAS  Google Scholar 

  46. Palinski W, Rosenfeld ME, Yl:a-Herttuala S, Gurtner GC, Socher SS, Butler SW, Parthasarathy S, Carew TE, Steinberg D, Witztum JL (1989) Low density lipoprotein undergoes oxidative modification in vivo. Proc Natl Acad Sci USA 86(4):1372–1376

    Article  PubMed  CAS  Google Scholar 

  47. Palinski W, Yla-Herttuala S, Rosenfeld ME, Butler SW, Socher SA, Parthasarathy S, Curtiss LK, Witztum JL (1990) Antisera and monoclonal antibodies specific for epitopes generated during oxidative modification of low density lipoprotein. Arteriosclerosis 10(3):325–335

    Article  PubMed  CAS  Google Scholar 

  48. Palinski W, Hörkkö S, Miller E, Steinbrecher UP, Powell HC, Curtiss LK, Witztum JL (1996) Cloning of monoclonal autoantibodies to epitopes of oxidized lipoproteins from apolipoprotein E-deficient mice. Demonstration of epitopes of oxidized low density lipoprotein in human plasma. J Clin Invest 98:800–814

    Article  PubMed  CAS  Google Scholar 

  49. Binder CJ, Horkko S, Dewan A, Chang MK, Kieu EP, Goodyear CS, Shaw PX, Palinski W, Witztum JL, Silverman GJ (2003) Pneumococcal vaccination decreases atherosclerotic lesion formation: molecular mimicry between Streptococcus pneumoniae and oxidized LDL. Nat Med 9(6):736–743

    Article  PubMed  CAS  Google Scholar 

  50. Caligiuri G, Khallou-Laschet J, Vandaele M, Gaston AT, Delignat S, Mandet C, Kohler HV, Kaveri SV, Nicoletti A (2007) Phosphorylcholine-targeting immunization reduces atherosclerosis. J Am Coll Cardiol 50(6):540–546

    Article  PubMed  CAS  Google Scholar 

  51. Schiopu A, Bengtsson J, Soderberg I, Janciauskiene S, Lindgren S, Ares MP, Shah PK, Carlsson R, Nilsson J, Fredrikson GN (2004) Recombinant human antibodies against aldehyde-modified apolipoprotein B-100 peptide sequences inhibit atherosclerosis. Circulation 110(14):2047–2052

    Article  PubMed  CAS  Google Scholar 

  52. Stemme S, Faber B, Holm J, Wiklund O, Witztum JL, Hansson GK (1995) T lymphocytes from human atherosclerotic plaques recognize oxidized low density lipoprotein. Proc Natl Acad Sci USA 92(9):3893–3897

    Article  PubMed  CAS  Google Scholar 

  53. Zhou X, Robertson AK, Hjerpe C, Hansson GK (2006) Adoptive transfer of CD4+ T cells reactive to modified low-density lipoprotein aggravates atherosclerosis. Arterioscler Thromb Vasc Biol 26(4):864–870

    Article  PubMed  CAS  Google Scholar 

  54. Palinski W, Miller E, Witztum JL (1995) Immunization of low density lipoprotein (LDL) receptor-deficient rabbits with homologous malondialdehyde-modified LDL reduces atherogenesis. Proc Natl Acad Sci USA 92:821–825

    Article  PubMed  CAS  Google Scholar 

  55. Ameli S, Hultgardh-Nilsson A, Regnstrom J, Calara F, Yano J, Cercek B, Shah PK, Nilsson J (1996) Effect of immunization with homologous LDL and oxidized LDL on early atherosclerosis in hypercholesterolemic rabbits. Arterioscler Thromb Vasc Biol 16(8):1074–1079

    Article  PubMed  CAS  Google Scholar 

  56. Klingenberg R, Lebens M, Hermansson A, Fredrikson GN, Strodthoff D, Rudling M, Ketelhuth DF, Gerdes N, Holmgren J, Nilsson J, Hansson GK (2010) Intranasal immunization with an apolipoprotein B-100 fusion protein induces antigen-specific regulatory T cells and reduces atherosclerosis. Arterioscler Thromb Vasc Biol 30(5):946–952

    Article  PubMed  CAS  Google Scholar 

  57. Greaves DR, Gordon S (2009) The macrophage scavenger receptor at 30 years of age: current knowledge and future challenges. J Lipid Res 50(Suppl):S282–S286

    Article  PubMed  Google Scholar 

  58. Nicoletti A, Caligiuri G, Törnberg I, Kodama T, Stemme S, Hansson GK (1999) The macrophage scavenger receptor type A directs modified proteins to antigen presentation. Eur J Immunol 29:512–521

    Article  PubMed  CAS  Google Scholar 

  59. Hjerpe C, Johansson D, Hermansson A, Hansson GK, Zhou X (2010) Dendritic cells pulsed with malondialdehyde modified low density lipoprotein aggravate atherosclerosis in Apoe(−/−) mice. Atherosclerosis 209(2):436–441

    Article  PubMed  CAS  Google Scholar 

  60. Hermansson A, Ketelhuth DF, Strodthoff D, Wurm M, Hansson EM, Nicoletti A, Paulsson-Berne G, Hansson GK (2010) Inhibition of T cell response to native low-density lipoprotein reduces atherosclerosis. J Exp Med 207(5):1081–1093

    Article  PubMed  CAS  Google Scholar 

  61. Fredrikson GN, Hedblad B, Berglund G, Alm R, Ares M, Cercek B, Chyu KY, Shah PK, Nilsson J (2003) Identification of immune responses against aldehyde-modified peptide sequences in apoB associated with cardiovascular disease. Arterioscler Thromb Vasc Biol 23(5):872–878

    Article  PubMed  CAS  Google Scholar 

  62. Luth S, Huber S, Schramm C, Buch T, Zander S, Stadelmann C, Bruck W, Wraith DC, Herkel J, Lohse AW (2008) Ectopic expression of neural autoantigen in mouse liver suppresses experimental autoimmune neuroinflammation by inducing antigen-specific Tregs. J Clin Invest 118(10):3403–3410

    PubMed  Google Scholar 

  63. Thomson AW, Knolle PA (2010) Antigen-presenting cell function in the tolerogenic liver environment. Nat Rev Immunol 10(11):753–766

    Article  PubMed  CAS  Google Scholar 

  64. Veillard NR, Steffens S, Burger F, Pelli G, Mach F (2004) Differential expression patterns of proinflammatory and antiinflammatory mediators during atherogenesis in mice. Arterioscler Thromb Vasc Biol 24(12):2339–2344

    Article  PubMed  CAS  Google Scholar 

  65. de Boer OJ, van der Meer JJ, Teeling P, van der Loos CM, van der Wal AC (2007) Low numbers of FOXP3 positive regulatory T cells are present in all developmental stages of human atherosclerotic lesions. PLoS One 2(1):e779

    Article  PubMed  Google Scholar 

  66. Ait-Oufella H, Salomon BL, Potteaux S, Robertson AK, Gourdy P, Zoll J, Merval R, Esposito B, Cohen JL, Fisson S, Flavell RA, Hansson GK, Klatzmann D, Tedgui A, Mallat Z (2006) Natural regulatory T cells control the development of atherosclerosis in mice. Nat Med 12(2):178–180

    Article  PubMed  CAS  Google Scholar 

  67. Mor A, Planer D, Luboshits G, Afek A, Metzger S, Chajek-Shaul T, Keren G, George J (2007) Role of naturally occurring CD4+ CD25+ regulatory T cells in experimental atherosclerosis. Arterioscler Thromb Vasc Biol 27(4):893–900

    Article  PubMed  CAS  Google Scholar 

  68. Hermansson A, Johansson DK, Ketelhuth DF, Andersson J, Zhou X, Hansson GK (2011) Immunotherapy with tolerogenic apolipoprotein B-100 loaded dendritic cells attenuates atherosclerosis in hypercholesterolemic mice. Circulation 123:1083–1091

    Article  PubMed  CAS  Google Scholar 

  69. Nilsson J, Hansson GK, Shah PK (2005) Immunomodulation of atherosclerosis: implications for vaccine development. Arterioscler Thromb Vasc Biol 25(1):18–28

    PubMed  CAS  Google Scholar 

  70. Hulthe J, Wikstrand J, Lidell A, Wendelhag I, Hansson GK, Wiklund O (1998) Antibody titers against oxidized LDL are not elevated in patients with familial hypercholesterolemia. Arterioscler Thromb Vasc Biol 18:1203–1211

    Article  PubMed  CAS  Google Scholar 

  71. Tornvall P, Waeg G, Nilsson J, Hamsten A, Regnstrom J (2003) Autoantibodies against modified low-density lipoproteins in coronary artery disease. Atherosclerosis 167(2):347–353

    Article  PubMed  CAS  Google Scholar 

  72. Fredrikson GN, Hedblad B, Berglund G, Alm R, Nilsson JA, Schiopu A, Shah PK, Nilsson J (2007) Association between IgM against an aldehyde-modified peptide in apolipoprotein B-100 and progression of carotid disease. Stroke 38(5):1495–1500

    Article  PubMed  CAS  Google Scholar 

  73. Sjogren P, Fredrikson GN, Samnegard A, Ericsson CG, Ohrvik J, Fisher RM, Nilsson J, Hamsten A (2008) High plasma concentrations of autoantibodies against native peptide 210 of apoB-100 are related to less coronary atherosclerosis and lower risk of myocardial infarction. Eur Heart J 29(18):2218–2226

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Medicine, Karolinska Institute, Stockholm, Sweden

    Göran K. Hansson

  2. Center for Molecular Medicine, Karolinska University Hospital L8:03, SE-17176, Stockholm, Sweden

    Göran K. Hansson

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Correspondence to Göran K. Hansson .

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  1. Medical University Innsbruck, Peter-Mayr-Strasse 4 a, Innsbruck, 6020, Austria

    Georg Wick

  2. Laboratory of Autoimmunity, Division of Experimental Pathophysiology, Biocenter, Innsbruck Medical University, Schöpfstraße 41, Innsbruck, 6020, Austria

    Cecilia Grundtman

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Hansson, G.K. (2012). Immunity to Low-Density Lipoprotein. In: Wick, G., Grundtman, C. (eds) Inflammation and Atherosclerosis. Springer, Vienna. https://doi.org/10.1007/978-3-7091-0338-8_21

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