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Interleukin-33 and Atherosclerosis

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Inflammation and Atherosclerosis

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Abstract

Interleukin (IL)-33 (also known as IL-1 F11) is a newly identified member of the IL-1 cytokine family with close amino acid sequence homology to IL-18 [1]. The human and mouse sequences for IL-33 have been mapped to chromosomes 9 (9p24.1) and 19 (19qc1), encoding proteins of 270 and 266 amino acids respectively. The protein is 30 kDa with a β-sheet trefoil fold structure characteristic of IL-1 family members. IL-33 appears to be a cytokine with dual function, acting both as a classical cytokine via its C-terminal domain and as an intracellular nuclear factor with autocrine transcriptional regulatory properties via its N-terminal domain.

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Authors and Affiliations

  1. Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, GBRC, University of Glasgow, Glasgow, G12 8TA, UK

    Foo Y. Liew & Ashley M. Miller

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  1. Foo Y. Liew
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  2. Ashley M. Miller
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Correspondence to Foo Y. Liew .

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Editors and Affiliations

  1. Medical University Innsbruck, Peter-Mayr-Strasse 4 a, Innsbruck, 6020, Austria

    Georg Wick

  2. Laboratory of Autoimmunity, Division of Experimental Pathophysiology, Biocenter, Innsbruck Medical University, Schöpfstraße 41, Innsbruck, 6020, Austria

    Cecilia Grundtman

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Liew, F.Y., Miller, A.M. (2012). Interleukin-33 and Atherosclerosis. In: Wick, G., Grundtman, C. (eds) Inflammation and Atherosclerosis. Springer, Vienna. https://doi.org/10.1007/978-3-7091-0338-8_12

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