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Generation of adipose tissue based on tissue engineering: An overview

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Handbook of Burns

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Abstract

Reconstruction of soft tissue is a very common scenario in plastic and reconstructive surgery. In 2008, 4.9 millions of patients had to undergo plastic reconstructive treatment in the USA, 3.8 of those in connection with tumor removal [1]. Apart from that, more than 12.8 millions of cosmetic surgeries were carried out including different forms of soft tissue augmentation with biologic and synthetic filling material and implants [1]. Shortcomings of the conventional plastic-surgical reconstruction of tissue defects i. e. transplanting autologous or allogenic tissue include donor site morbidity in autologous transplants and immunogenicity of allogenic transplants [27, 45, 46, 50]. In addition, the body’s own resources are limited so availability is restricted.

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References

  1. Alhadlaq A, Tang M, Mao JJ (2005) Engineered adipose tissue from human mesenchymal stem cells maintains predefined shape and dimension: implications in soft tissue augmentation and reconstruction. Tissue Eng 11 (3–4): 556–566

    Article  PubMed  CAS  Google Scholar 

  2. Beahm EK, Walton RL, Patrick Jr CW (2003) Progress in adipose tissue construct development. Clin Plast Surg 30 (4): 547–558

    Article  PubMed  Google Scholar 

  3. Boschert MT, Beckert BW, Puckett ChL, Concannon MJ (2002) Analysis of lipocyte viability after liposuction. Plast Reconstr Surg 109: 761–765

    Article  PubMed  Google Scholar 

  4. Burg KJ, Holder WD, Culberson CR, Beiler RJ, Greene KG, A. B. Loebsack AB et al (1999) Parameters affecting cellular adhesion to polylactide films. J Biomater Sci Polym Ed 10 (2): 147–161

    Article  PubMed  CAS  Google Scholar 

  5. Burg KJ, Boland T (2003) Minimally invasive tissue engineering composites and cell printing. IEEE Eng Med Biol Mag 22 (5): 84–91

    Article  PubMed  Google Scholar 

  6. Butterwith SC (1994) Molecular events in adipocyte development. Pharmacol Ther 61 (3): 399–411

    Article  PubMed  CAS  Google Scholar 

  7. Cao Y, Sun Z, Liao L, Meng Y, Han Q, Zhao RC (2005) Human adipose tissue-derived stem cells differentiate into endothelial cells in vitro and improve postnatal neovascularization in vivo. Biochem Biophys Res Commun 332 (2): 370–379

    Article  PubMed  CAS  Google Scholar 

  8. Cavin AN, Ellis SE, Burg KJL (2005) Adipocyte response to injectable breast tissue engineering scaffolds. In: Transactions of the 30 th annual meeting of the Society for Biomaterials, Memphis, TN

    Google Scholar 

  9. Choi YS, Park SN, Suh H (2005) Adipose tissue engineering using mesenchymal stem cells attached to injectable PLGA spheres. Biomaterials 26 (29): 5855–5863

    Article  PubMed  CAS  Google Scholar 

  10. Coleman SR, Saboeiro A (2007) Fat grafting to the breast revisited: safety and efficacy. Ann Plast Surg 119(3): 775–785

    CAS  Google Scholar 

  11. Cornelius P, MacDougald OA, Lane MD (1994) Regulation of adipocyte development. Annu Rev Nutr 14: 99–129

    Article  PubMed  CAS  Google Scholar 

  12. Cowan C, Shi Y, Aalami O et al (2004) Adipose-derived adult stromal cells heal critical-size mouse calvarial defects. Nat Biotechnol 22(5): 560–567

    Article  PubMed  CAS  Google Scholar 

  13. Croissandeau G, Chretien M, Mbikay M (2002) Involvement of matrix metalloproteinases in the adipose conversion of 3T3-L1 preadipocytes, Biochem J 364 (Part 3): 739–746

    Article  PubMed  CAS  Google Scholar 

  14. De Bari C, Dell Accio F, Luyten FP (2004) Failure of in vitro-differentiated mesenchymal stem cells from the synovial membrane to form ectopic stable cartilage in vivo. Arthritis Rheum 50: 142–150

    Google Scholar 

  15. De Ugarte DA, Ashjian PH, Elbarbary A, Hedrick MH (2003) Future of fat as raw material for tissue regeneration, Ann Plast Surg 50 (2): 215–219

    Article  PubMed  Google Scholar 

  16. Eiselt P, Yeh J, Latvala RK, Shea LD, Mooney DJ (2000) Porous carriers for biomedical applications based on alginate hydrogels. Biomaterials 21 (19): 1921–1927

    Article  PubMed  CAS  Google Scholar 

  17. Fischbach C, Spruss T, Weiser B, Neubauer M, Becker C, Hacker M et al (2004) Generation of mature fat pads in vitro and in vivo utilizing 3-D long-term culture of 3T3-L1 preadipocytes. Exp Cell Res 300 (1): 54–64

    Article  PubMed  CAS  Google Scholar 

  18. Fuchs JR, Nasseri BA, Vacanti JP (2001) Tissue engineering: a 21st century solution to surgical reconstruction. Ann Thorac Surg 72 (2): 577–591

    Article  PubMed  CAS  Google Scholar 

  19. Gabbay JS, Heller JB, Mitchell SA, Zuk PA, Spoon DB, Wasson KL, Jarrahy R, Benhaim P, Bradley JP (2006) Osteogenic potentiation of human adipose-derived stem cells in a 3-dimensional matrix. Ann Plast Surg 57(1): 89–93

    Article  PubMed  CAS  Google Scholar 

  20. Gentleman E, Nauman EA, Livesay GA, Dee KC (2006) Collagen composite biomaterials resist contraction while allowing development of adipocytic soft tissue in vitro. Tissue Eng 12 (6): 1639–1649

    Article  PubMed  CAS  Google Scholar 

  21. Giorgino F, Laviola L, Eriksson JW (2005) Regional differences of insulin action in adipose tissue: insights from in vivo and in vitro studies. Acta Physiol Scand 183 (1): 13–30

    Article  PubMed  CAS  Google Scholar 

  22. Goessler UR, Hörmann K, Riedel F (2005) Adult stem cells in plastic reconstructive surgery. Int J Mol Med 15: 899–905

    PubMed  CAS  Google Scholar 

  23. Halberstadt C, Austin C, Rowley J, Culberson C, Loebsack A, Wyatt S et al (2002) A hydrogel material for plastic and reconstructive applications injected into the subcutaneous space of a sheep. Tissue Eng 8 (2): 309–319

    Article  PubMed  CAS  Google Scholar 

  24. Halbleib M, Skurk T, de Luca C, von Heimburg D, Hauner H (2003) Tissue engineering of white adipose tissue using hyaluronic acid-based scaffolds. I: in vitro differentiation of human adipocyte precursor cells on scaffolds. Biomaterials 24 (18): 3125–3132

    Google Scholar 

  25. Hemmrich K, von Heimburg D, Rendchen R, Di Bartolo C, Milella E, Pallua N (2005) Implantation of preadipocyte-loaded hyaluronic acid-based scaffolds into nude mice to evaluate potential for soft tissue engineering. Biomaterials 26 (34): 7025–7037

    Article  PubMed  CAS  Google Scholar 

  26. Hurvitz KA, Kobayashi M, Evans GR (2006) Current options in head and neck reconstruction. Plast Reconstr Surg 118: 122e–133e

    Article  PubMed  Google Scholar 

  27. Junqueira LC, Carneiro J, Gratzl M (2005) Fettgewebe In: Histologie. Springer, Berlin Heidelberg, S 75–80

    Google Scholar 

  28. Katz AJ, Llull R, Hedrick MH, Futrell JW (1999) Emerging approaches to the tissue engineering of fat. Clin Plast Surg 26 (4): 587–603

    PubMed  CAS  Google Scholar 

  29. Kaufman MR, Bradley JP, Dickinson B et al (2007) Autologous fat transfer national consensus survey: trends in techniques for harvest, preparation, and application, and perception of short-and long-term results. Plast Reconstr Surg 119(1): 323–331

    Article  PubMed  CAS  Google Scholar 

  30. Kawaguchi N, Toriyama K, Nicodemou-Lena E, Inou K, Torii S, Kitagawa Y (1998) De novo adipogenesis in mice at the site of injection of basement membrane and basic fibroblast growth factor. Proc Natl Acad Sci USA 95 (3): 1062–1066

    Article  PubMed  CAS  Google Scholar 

  31. Keck M, Janke J, Ueberreiter K (2007) The influence of different local anaesthetics on the viability of preadipocytes. Handchir Mikrochir Plast Chir 39(3): 215–9

    Article  PubMed  CAS  Google Scholar 

  32. Keck M, Haluza D, Burjak S, Eisenbock B, Kamolz L P, Frey M (2009) Cultivation of keratinocytes and preadipocytes on a collagen-elastin scaffold (Matriderm®): First results of an in vitro study. Eur Surg 41/4: 189–193

    Article  Google Scholar 

  33. Kimura Y, Ozeki M, Inamoto T, Tabata Y (2002) Time course of de novo adipogenesis in matrigel by gelatin microspheres incorporating basic fibroblast growth factor. Tissue Eng 8 (4): 603–613

    Article  PubMed  CAS  Google Scholar 

  34. Kral JG, Crandall DL (1999) Development of a human adipocyte synthetic polymer scaffold. Plast Reconstr Surg 104 (6): 1732–1738

    Article  PubMed  CAS  Google Scholar 

  35. Mandrup S, Lane MD (1997) Regulating adipogenesis. J Biol Chem 272(9): 5367–5370

    Article  PubMed  CAS  Google Scholar 

  36. Masuda T, Furue M, Matsuda T (2004) Novel strategy for soft tissue augmentation based on transplantation of fragmented omentum and preadipocytes. Tissue Eng 10 (11–12): 1672–1683

    Article  PubMed  CAS  Google Scholar 

  37. Masuda T, Furue M, Matsuda T (2004) Photocured, styrenated gelatin-based microspheres for de novo adipogenesis through corelease of basic fibroblast growth factor, insulin, and insulin-like growth factor I. Tissue Eng 10 (3–4): 523–535

    Article  PubMed  CAS  Google Scholar 

  38. Patel PN, Gobin AS, West JL, Patrick Jr CW (2005) Poly(ethylene glycol) hydrogel system supports preadipocyte viability, adhesion, and proliferation. Tissue Eng 11 (9–10): 1498–1505

    Article  PubMed  CAS  Google Scholar 

  39. Patrick CW, Mikos AG, McIntire LV (1998) Frontiers in tissue engineering, 1st edn. Pergamon, Oxford, UK and New York

    Google Scholar 

  40. Patrick Jr CW (2000) Adipose tissue engineering: the future of breast and soft tissue reconstruction following tumor resection. Semin Surg Oncol 19 (3): 302–311

    Article  PubMed  Google Scholar 

  41. Patrick Jr CW (2001) Tissue-engineering strategies for adipose tissue repair. Anat Rec 263 (4): 361–366

    Article  PubMed  CAS  Google Scholar 

  42. Patrick CW Jr, Uthamanthil R, Beahm E, Frye C (2008) Animal models for adipose tissue engineering. Tissue Eng Part B Rev 14(2): 167–178

    Article  PubMed  CAS  Google Scholar 

  43. Riedel F, Hormann K (2005) Plastic surgery of skin defects in the face-principles and perspectives. HNO 53: 1020–1036

    Article  PubMed  CAS  Google Scholar 

  44. Riedel F, Reinhart Goessler U, Grupp S, Bran G, Hörmann K, Verse T (2006) Management of radiation-induced tracheocutaneous tissue defects by transplantation of an ear cartilage graft and deltopectoral flap. Auris Nasus Larynx 33(1): 79–84

    Article  PubMed  Google Scholar 

  45. Riedel F, Goessler UR, Stern-Straeter J, Riedel K, Hörmann K (2008) Regenerative medicine in head and neck reconstructive surgery. HNO 56(3): 262–274

    Article  PubMed  CAS  Google Scholar 

  46. Rowley JA, Madlambayan G, Mooney DJ (1999) Alginate hydrogels as synthetic extracellular matrix materials. Biomaterials 20 (1): 45–53

    Article  PubMed  CAS  Google Scholar 

  47. Rubin JP, Bennett JM, Doctor JS, Tebbets BM, Marra KG (2007) Collagenous microbeads as a scaffold for tissue Engineering with adipose-derived stem cells. Plast Reconstr Surg 120(2): 414–424

    Article  PubMed  CAS  Google Scholar 

  48. Schipper BM, Marra KG, Zhang W, Donnenberg AD, Rubin JP(2008) Regional anatomic and age effects on cell function of human adipose-derived stem cells. Ann Plast Surg 60(5): 583–544

    Article  Google Scholar 

  49. Shenaq SM, Yuksel E (2002) New research in breast reconstruction: adipose tissue engineering. Clin Plast Surg 29 (1): 111–125

    Article  PubMed  Google Scholar 

  50. Shiffman MA, Mirrafati S (2001) Fat transfer techniques: The effect of harvest and transfer methods on adipocyte viability and review of the literature. Dermatol Surg 27(9): 819–826

    Article  PubMed  CAS  Google Scholar 

  51. Smith P, Adams WP, Lipschitz, AH et al (2006) Autologous human fat grafting: effect of harvesting and preparation techniques on adipocyte graft survival. Plast Reconstr Surg 117(6): 1836–1844

    Article  PubMed  CAS  Google Scholar 

  52. Tabata Y, Miyao M, Inamoto T, Ishii T, Hirano Y, Yamaoki Y, et al (2000) De novo formation of adipose tissue by controlled release of basic fibroblast growth factor. Tissue Eng 6(3): 279–289

    Article  PubMed  CAS  Google Scholar 

  53. Tholpady SS, Llull R, Ogle RC, Rubin JP, Futrell JW, Katz AJ (2006) Adipose tissue: stem cells and beyond. Clin Plast Surg 33(1): 55–62

    Article  PubMed  Google Scholar 

  54. Toma JG, Akhavan M, Fernandes KJ et al (2001) Isolation of multipotent adult stem cells from the dermis of mammalian skin. Nat Cell Biol 3: 778–784

    Article  PubMed  CAS  Google Scholar 

  55. Toriyama K, Kawaguchi N, Kitoh J, Tajima R, Inou K, Kitagawa Y et al (2002) Endogenous adipocyte precursor cells for regenerative soft-tissue engineering. Tissue Eng 8(1): 157–165

    Article  PubMed  CAS  Google Scholar 

  56. von Heimburg D, Serov G, Oepen T, Pallua N (2003) Fat tissue engineering. In: Ashammakhi N, Ferretti P (eds) Topics in Tissue Engineering. Chapter 8: 1–16

    Google Scholar 

  57. Von Heimburg D, Kuberka M, Rendchen R, Hemmrich K, Rau G, Pallua N (2003) Preadipocyte-loaded collagen scaffolds with enlarged pore size for improved soft tissue engineering. Int J Artif Organs 26 (12): 1064–1076

    Google Scholar 

  58. Wei Y, Hu Y, Lv R, Li D (2006) Regulation of adipose-derived adult stem cells differentiating into chondrocytes with the use of rhBMP-2. Cytotherapy 8(6): 570–579

    Article  PubMed  CAS  Google Scholar 

  59. Wozniak SE, Gee LL, Wachtel MS, Frezza EE (2009) Adipose tissue: the new endocrine organ? A review article. Dig Dis Sci 54(9): 1847–1856

    Article  PubMed  Google Scholar 

  60. Yuksel E, Weinfeld AB, Cleek R, Waugh JM, Jensen J, Boutros S et al (2000) De novo adipose tissue generation through long-term, local delivery of insulin and insulin-like growth factor-1 by PLGA/PEG microshperes in an in vivo rat model: a novel concept and capability. Plast Reconstr Surg 105: 1721–1729

    Article  PubMed  CAS  Google Scholar 

  61. Zuk PA, Zhu M, Mizuno H et al (2001) Multilineage cells from human adipose tissue: implications for cellbased therapies. Tissue Eng 7: 211–228

    Article  PubMed  CAS  Google Scholar 

  62. Zuk PA, Zhu M, Ashjian P, De Ugarte DA, Huang JI, Mizuno H et al (2002) Human adipose tissue is a source of multipotent stem cells. Mol Biol Cell 13 (12): 4279–4295

    Article  PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Surgery, Division of Plastic and Reconstructive Surgery, Medical University of Vienna, Vienna, Austria

    Maike Keck, David B. Lumenta & Lars-Peter Kamolz M.D., Ph.D., M.Sc.

  2. Department of Surgery, Section of Plastic, Aesthetic and Reconstructive Surgery, State Hospital Wiener Neustadt, Wiener Neustadt, Austria

    Lars-Peter Kamolz M.D., Ph.D., M.Sc.

Authors
  1. Maike Keck
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  2. David B. Lumenta
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  3. Lars-Peter Kamolz M.D., Ph.D., M.Sc.
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Correspondence to Lars-Peter Kamolz M.D., Ph.D., M.Sc. .

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Editors and Affiliations

  1. Plastische, Aesthetische und Rekonstruktive Chirurgie, Landesklinikum Wiener Neustadt, Wiener Neustadt, Austria

    Lars-Peter Kamolz M.D., M.Sc

  2. Sunnybrook Health Sciences Centre, Department of Surgery, Division of Plastic Surgery, University of Toronto, Sunnybrook Research Institute, Toronto, ON, Canada

    Marc G. Jeschke M.D., Ph.D.

  3. Universitätsklinikum Erlangen, Plastisch- und Handchirurgische Klinik, Erlangen, Germany

    Raymund E. Horch M.D., Ph.D.

  4. Evangelische Elisabeth Klinik Krankenhausbetriebs gGmbH, Berlin, Germany

    Markus Küntscher M.D., Ph.D.

  5. Prednosta Kliniky popálenin, a rekonstrukcní chirurgie, FN Brno, Czech Republic

    Pavel Brychta M.D., Ph.D., C.Sc.

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Keck, M., Lumenta, D.B., Kamolz, LP. (2012). Generation of adipose tissue based on tissue engineering: An overview. In: Kamolz, LP., Jeschke, M.G., Horch, R.E., Küntscher, M., Brychta, P. (eds) Handbook of Burns. Springer, Vienna. https://doi.org/10.1007/978-3-7091-0315-9_15

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  • DOI: https://doi.org/10.1007/978-3-7091-0315-9_15

  • Publisher Name: Springer, Vienna

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  • Online ISBN: 978-3-7091-0315-9

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