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Biological Adhesive Systems pp 237–259Cite as

Properties and Potential Alternative Applications of Fibrin Glue

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Abstract

Clot formation is an essential mechanism for wound closure and its principle is ubiquitous in the animal kingdom, comprising invertebrates such as arthropods, echinoderms, and cephalopods as well as all classes of vertebrates (Alsberg and Clark, 1908; Xu and Doolittle, 1990; Feral, 2010). The general principle of coagulation is the conversion of proteins to fibrous material by enzyme reaction in the presence of blood cells. Although the reacting partners (proteins, enzymes, and cell types) strongly differ between the animal groups, the final product always consists mainly or partly of fibrous material. Its functionality seems to rely on the formation of a gauze-like cover sealing the lesion.

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Authors and Affiliations

  1. Department of Traumatology, Medical University of Vienna, Waehringer Guertel 18–20, 1090, Vienna, Austria

    Sylvia Nürnberger

  2. Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Austrian Cluster for Tissue Regeneration, Donaueschingenstrasse 13, 1200, Vienna, Austria

    Sylvia Nürnberger, Susanne Wolbank, Tatjana J. Morton, Georg A. Feichtinger, Alexandra Meinl, Martijn van Griensven & Heinz Redl

  3. Red Cross Blood Transfusion Service of Upper Austria, Austrian Cluster for Tissue Regeneration, Krankenhausstrasse 7, 4017, Linz, Austria

    Anja Peterbauer-Scherb & Christian Gabriel

  4. Baxter Innovations GmbH, Industriestraße 131, 1221, Vienna, Austria

    Alfred Gugerell, Michaela Bittner & Waltraud Pasteiner

  5. Department of Biomedical Engineering, Tampere University of Technology, P.O. Box 692, 331010, Tampere, Finland

    Lila Nikkola

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  1. Sylvia Nürnberger
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  2. Susanne Wolbank
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  3. Anja Peterbauer-Scherb
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  9. Michaela Bittner
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  10. Waltraud Pasteiner
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  11. Lila Nikkola
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  12. Christian Gabriel
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  13. Martijn van Griensven
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  14. Heinz Redl
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Editor information

Editors and Affiliations

  1. Core Facility Cell Imaging and Ultrastructure Research Faculty of Life Science, University of Vienna, Vienna, Austria

    Janek von Byern

  2. Department of Adhesive Bonding Technology and Surfaces, Adhesives and Polymer Chemistry, Fraunhofer Institute for Manufacturing Technology and Advanced Materials (IFAM), Bremen, Germany

    Ingo Grunwald

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Nürnberger, S. et al. (2010). Properties and Potential Alternative Applications of Fibrin Glue. In: von Byern, J., Grunwald, I. (eds) Biological Adhesive Systems. Springer, Vienna. https://doi.org/10.1007/978-3-7091-0286-2_16

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