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Fibrin: The Very First Biomimetic Glue — Still a Great Tool

  • Chapter
Biological Adhesive Systems

Abstract

The phenomenon of blood clotting fascinated even the very earliest of philosophers and scientists. They marveled at the fact that the body could repair itself, stopping blood flow and healing its own defect. The idea of using the clotting mechanism to heal and close wounds also seems to have been a dream of the first medical doctors. Galen (129–199 AD) observed the clotting process in more detail and described “fibrae” or “threads” in both circulating blood and in clots and in 1666 Malpighi found “long tough threads” and “a nerve-like network of threads” in washed clots. These “threads” or fibers would later be identified as fibrin, the substance that is the end product of the coagulation cascade and that forms the basis of the blood clot. In 1905, the modern coagulation cascade as we know it was consolidated by Morawitz.

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Authors and Affiliations

  1. Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Austrian Cluster for Tissue Regeneration, Donaueschingenstrasse 13, 1200, Vienna, Austria

    James Ferguson, Sylvia Nürnberger & Heinz Redl

  2. Department of Traumatology, Medical University of Vienna, Waehringer Guertel 18–20, 1090, Vienna, Austria

    Sylvia Nürnberger

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  1. James Ferguson
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  2. Sylvia Nürnberger
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  3. Heinz Redl
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Editors and Affiliations

  1. Core Facility Cell Imaging and Ultrastructure Research Faculty of Life Science, University of Vienna, Vienna, Austria

    Janek von Byern

  2. Department of Adhesive Bonding Technology and Surfaces, Adhesives and Polymer Chemistry, Fraunhofer Institute for Manufacturing Technology and Advanced Materials (IFAM), Bremen, Germany

    Ingo Grunwald

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© 2010 Springer-Verlag/Wien

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Ferguson, J., Nürnberger, S., Redl, H. (2010). Fibrin: The Very First Biomimetic Glue — Still a Great Tool. In: von Byern, J., Grunwald, I. (eds) Biological Adhesive Systems. Springer, Vienna. https://doi.org/10.1007/978-3-7091-0286-2_15

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