Abstract
Antibiotics used in clinical medicine for the treatment of infectious diseases frequently target bacterial protein synthesis, as illustrated by macrolides, ketolides, lincosamides, oxazolidinones, aminoglycosides, and tetracyclines (Gale et al., 1981). In general, antibiotics target the ribosome at sites of functional relevance, e. g. the sites of decoding, translocation, and peptidyl transfer. The emergence of antibiotic resistance and the toxicity associated with some of the available agents ask for a further exploitation of the ribosome as a drug target.
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Akbergenov, R. et al. (2011). Decoding and deafness: Two sides of a coin. In: Rodnina, M.V., Wintermeyer, W., Green, R. (eds) Ribosomes. Springer, Vienna. https://doi.org/10.1007/978-3-7091-0215-2_20
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DOI: https://doi.org/10.1007/978-3-7091-0215-2_20
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