Abstract
Translation initiation is the most strongly regulated phase of protein synthesis during which the synthesis of a given protein is decided on. Initiation is the least conserved step of translation, since bacteria, archaea and eukarya have distinct and very different ways to initiate translation, and many different trans-acting factors are involved in the process. In bacteria, translation initiation comprises the consecutive formation of three major intermediary initiation complexes that are assembled via a multi-step process and that differ in composition and in conformation. At the end of the initiation process, an active 70S ribosomal initiation complex (70S IC) has formed which can enter peptide bond formation.
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Simonetti, A., Marzi, S., Myasnikov, A.G., Ménétret, JF., Klaholz, B.P. (2011). Insights into translation initiation and termination complexes and into the polysome architecture. In: Rodnina, M.V., Wintermeyer, W., Green, R. (eds) Ribosomes. Springer, Vienna. https://doi.org/10.1007/978-3-7091-0215-2_10
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