Skip to main content
SpringerLink
Log in

Tumormarker

  • Chapter
Labormedizin

  • 6502 Accesses

Auszug

Als Tumormarker werden Substanzen bezeichnet, deren Auftreten und Konzentrationsänderung in gewisser Beziehung mit der Entstehung und dem Wachstum von malignen Tumoren eines Individuums stehen. Es wäre von großem Vorteil, wenn es mit Hilfe eines einfachen Labortestes möglich wäre, ein Karzinom zu einem frühen, daher noch heilbaren Stadium, zu diagnostizieren. Auf alle Fälle in einem Stadium in dem noch keine Metastasen aufgetreten sind. Einen derartigen Test gibt es aber leider noch nicht. Dazu kommt, dass die Tumormarker-Spiegel in Körperflüssigkeiten (Blut, Harn etc.) auch bei benignen Erkrankungen, oder durch präanalytische Einflussgrößen erhöht sein können. Tumormarker sind daher als Screeningparameter (mit wenigen Ausnahmen) nicht geeignet! (1, 2, 3, 4).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 109.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 149.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

Allgemein

  • Thomas L (1998) Labor und Diagnose. TH-Books Verlagsgesellschaft mbH, Frankfurt/Main

    Google Scholar 

Speziell

  1. Joss R, Cerny T (1990) Sinn und Unsinn von Tumormarkern in der Praxis. Schweiz Med Wschr 120: 693–703

    PubMed  CAS  Google Scholar 

  2. Bates S E, Longo D L (1985) Tumor markers: value and limitations in the management of cancer patients. Cancer Treat Rev 12(3): 163–207

    Article  PubMed  CAS  Google Scholar 

  3. Berlin N I (1981) Tumor markers in cancer prevention and detection. Cancer 47[5 Suppl]: 1151–1153

    Article  PubMed  CAS  Google Scholar 

  4. Pavlidis N, Kalef-Ezra J, Briassoulis E, Skarlos D, Kosmidis P, Saferiadis K, Bairaktari E, Bafaloukos D, Maravegias A, Theoharis D (1994) Evaluaton of six tumor markers in patients with varcinoma of unknown primary. Med Pediatr Oncol 22(3):162–167

    Article  PubMed  CAS  Google Scholar 

  5. Sturgeon C (2002) Practice guidelines for tumor marker use in the clinic. Clin Chem 48(8): 1151–1159

    PubMed  CAS  Google Scholar 

  6. Sturgeon C (2001) Tumor markers in the laboratory: closing the guideline-practice gap. Clin Biochem 34: 353–359

    Article  PubMed  CAS  Google Scholar 

  7. Soletormos G, Schioler V, Nielsen D, Skovsgaard T, Dombernowsky P (1993) Interpretation of results for tumor markers on the basis of analytical imprecision and biological variation. Clin Chem 39(10): 2077–2083

    PubMed  CAS  Google Scholar 

  8. Tuxen M K, Söetormos G, Petersen P H, Schioler V, Dombernowsky P (1999) Assessment of biological variation and analytical imprecision of CA 125, CEA, and TPA in relation to monitoring of ovarian cancer. Gyn One 74: 12–22

    Article  CAS  Google Scholar 

  9. Plebani M, Giacomini A, Beghi L, de Paoli M, Roveroni G, Galeotti F, Vorsini A, Fraser CG (1996) Serum tumor markers in monitorino patients: interpretation of results using analytical and biological variation. Anti-cancer Res 16(4B): 2249–2252

    CAS  Google Scholar 

  10. Nap M, Mollgard K, Burtin P, Fleuren G J (1988) Immunohistochemistry of carcino-embryonic antigen in the embryo, fetus and adult. Tumour Biol 9(2–3): 145–153

    Article  PubMed  CAS  Google Scholar 

  11. Fukuda I, Yamakado M, Kiyose H (1998) Influence of smoking on serum carcinoembryonic antigen levels in subjects who underwent multiphasic health testing and services. J Med Syst 22(2): 89–93

    Article  PubMed  CAS  Google Scholar 

  12. Ohwada A, Takahashi H, Nagaoka I, Iwabuchi K, Mikami O, Kira S (1995) Effect of cigarette smoke on the mRNA and protein expression of carcinoembryonic antigen (CEA), a possible chemoattractant for neutrophils in human bronchioalveolar tissues. Thorax 50(6): 651–657

    Article  PubMed  CAS  Google Scholar 

  13. Lurie B B, Loewenstein M S, Zamcheck N (1975) Elevated carcinoembryonic antigen levels and biliary tract obstruction. JAMA 233(4): 326–330

    Article  PubMed  CAS  Google Scholar 

  14. Mihmanli M, Dilege E, Demir U, Coskun H, Eroglu T, Uysalol M D (2004) The use of tumor markers as predictors of prognosis in gastric cancer. Hepatogastroenterology 51(59): 1544–1547

    PubMed  Google Scholar 

  15. Duffy M J (2001) Carcinoembryonic antigen as a marker for colorectal cancer: Is it clinically useful? Clin Chem 47(4): 624–630

    PubMed  CAS  Google Scholar 

  16. Anonymous (1996) Clinical practice guidelines fort he use of tumor markers in breast and colorectal cancer. J Clin Oncol 14(10): 2843–2877

    Google Scholar 

  17. Chalasani N, Horlander J C, Said A, Hoen H, Kopecky K K, Stockberger S M, Manam R, Kwo P Y, Lumeng L (1999) Screening for hepatocellular carcinoma in patients with advanced cirrhosis. Am J Gastroenterol 94: 2988–2993

    Article  PubMed  CAS  Google Scholar 

  18. Gambarin-Gelwan M, Wolf D C, Shapiro R, Schwartz M W, Min A D (2000) Sensitivity of commonly available screening tests in detecting hepatocellular carcinoma in cirrhotic patients undergoing liver transplantation. Am J Gastroenterol 95(6): 1535–1538

    Article  PubMed  CAS  Google Scholar 

  19. Arguedas M R, Chen V K, Eluobeidi M A, Fallon M B (2003) Screening for hepatocellular carcinoma in patients with hepatitis C cirrhosis: a cost-utility analysis. Am J Gastroenterol 98(3): 679–690

    Article  PubMed  Google Scholar 

  20. Stenman U H (2004) Standardization of assays for human chorionic gonadotropin. Clin Chem 50(5): 798–800

    Article  PubMed  CAS  Google Scholar 

  21. Birken S, Berger P, Bidart J M, Weber M, Britow A, Norman R, Sturgeon C, Stenman U H (2003) Preparation and characterization of new WHO reference reagents for human chorionic gonadotropin and metabolites. Clin Chem 49(1): 144–154

    Article  PubMed  CAS  Google Scholar 

  22. Huber P R, Bischof P, Kretschmer R, Truschnig M, Halwachs G, Schmidt M (1996) CA 15-3: A multicentre evaluation of automated and manual tests. Eur J Clin Chem Biochem 34: 77–84

    CAS  Google Scholar 

  23. Veltri R W, Miller M C, O’Dowd G J, Partin A W (2002) Impact of age on total and complexed prostate-specific antigen cutoffs in a contemporary referral series of men with prostate cancer. Urology 60[Suppl 4A]: 47–52

    Article  PubMed  Google Scholar 

  24. Cheli C D, Levine R, Cambetas D R, Kolker J D, Roberts S B (2002) Age-related reference ranger for complexed prostate-specific antigen and complexed total prostate-specific antigen ratio: results from east texas medical center cancer institute screening campaign. Urology 60[Suppl 4A]: 53–59

    Article  PubMed  Google Scholar 

  25. Ku J H, Kim M E, Lee N K, Park Y H, Ahn J O (2003) Influence of age, anthropometry, and hepatic and renal function on serum prostate-specific antigen levels in healthy middle-age men. Urology 61: 132–136

    Article  PubMed  Google Scholar 

  26. Minardi D, Galosi A B, Dell’Atti L, Hanitzsch H, Mario P, Muzzonigro G (2002) Production of serum-free and total prostate-specific antigen due to prostatic intraepithelial neoplasia. Scand J Urol Nephrol 36: 323–329

    Article  PubMed  Google Scholar 

  27. Tanguay S, Begin L R, Elhilali M M, Behlouli H, Karakiewicz P I, Aprikian A G (2002) Comparative evaluation of total PSA, free/total PSA, and complexed PSA in prostate cancer detection. Urology 59: 261–265

    Article  PubMed  CAS  Google Scholar 

  28. Guadagni F, Roselli M, Amato T, Cosimelli M, Perri P, Casale V, Carlini M, Santoro E, Cavaliere R, Greiner J W (1992) CA 72-4 measurement of tumor associated glycoprotein 72 (TAG-72) as a serum marker in the magagement of gastric carcinoma. Cancer Res 52(5): 1222–1227

    PubMed  CAS  Google Scholar 

  29. Lai I R, Lee W J, Huang M T, Lin H H (2002) Comparison of serum CA72-4, CEA, TPA, CA 19-9 and CA125 levels in gastric cancer patients and correlation with recurrence. Hepatogastroenterology 49(46): 1157–1160

    PubMed  Google Scholar 

  30. Filella X, Molina R, Jo J, Bedini J L, Joseph J, Ballesta A M (1992) Tumor associated glycoprotein-72 (TAG-72) levels in patients with non-malignant and malignant disease. Bull Cancer 79(3): 271–277

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institut für Medizinische und Chemische Labordiagnostik, Krankenhaus Steyr, Steyr, Österreich

    Prim. Univ.-Prof. Dr. Gabriele Halwachs-Baumann MSc, MBA

Authors
  1. Prim. Univ.-Prof. Dr. Gabriele Halwachs-Baumann MSc, MBA
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

Copyright information

© 2011 Springer-Verlag/Wien

About this chapter

Cite this chapter

Halwachs-Baumann, G. (2011). Tumormarker. In: Labormedizin. Springer, Vienna. https://doi.org/10.1007/978-3-7091-0203-9_14

Download citation

  • DOI: https://doi.org/10.1007/978-3-7091-0203-9_14

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-7091-0202-2

  • Online ISBN: 978-3-7091-0203-9

  • eBook Packages: Medicine (German Language)

Publish with us

Policies and ethics

Search

Navigation