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Balanced Alpha/Beta Blockade of Adrenoceptors / Balancierte Blockade von Alpha- und Beta-Adrenozeptoren pp 151–159Cite as

The Concept of Combined Alpha-Beta-Blockade in Coronary Heart Disease

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Part of the book series: Methods in Clinical Pharmacology ((MECLPH))

Summary

The pathophysiological haemodynamic profile of coronary heart disease is dominated by the activities of the sympathetic nervous system. Attenuation of stimuli over a single sympathetic pathway allows unrestrained and enhanced acitivity of a potentially hazardous nature over the unblocked pathway. Controlled combined alphabeta-adrenoceptor blockade appears to afford the most rational therapeutic approach to this common disease syndrome. Simultaneous blockade of both sympathoadrenergic receptors does not appear to adversely alter the metabolic or other neuroendocrine profiles, thus enhancing the therapeutic prospects for labetalol in the long-term treatment of this common chronic disease syndrome.

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Authors and Affiliations

  1. Department of Cardiovascular Studies, University of Leeds, England

    S. H. Taylor

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  1. S. H. Taylor
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Editors and Affiliations

  1. University Clinic, Frankfurt am Main, Federal Republic of Germany

    Norbert Rietbrock (Professor of Clinical Pharmacology) & Barry G. Woodcock (Senior Lecturer in Clinical Pharmacology) (Professor of Clinical Pharmacology) &  (Senior Lecturer in Clinical Pharmacology)

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© 1984 Springer Fachmedien Wiesbaden

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Taylor, S.H. (1984). The Concept of Combined Alpha-Beta-Blockade in Coronary Heart Disease. In: Rietbrock, N., Woodcock, B.G. (eds) Balanced Alpha/Beta Blockade of Adrenoceptors / Balancierte Blockade von Alpha- und Beta-Adrenozeptoren. Methods in Clinical Pharmacology. Vieweg+Teubner Verlag, Wiesbaden. https://doi.org/10.1007/978-3-663-20205-9_16

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  • DOI: https://doi.org/10.1007/978-3-663-20205-9_16

  • Publisher Name: Vieweg+Teubner Verlag, Wiesbaden

  • Print ISBN: 978-3-528-07922-2

  • Online ISBN: 978-3-663-20205-9

  • eBook Packages: Springer Book Archive

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