Abstract
White New Zealand rabbits were fed with a semisynthetic diet for varying lengths of time. This diet contained 0,5% cholesterol (CH-F) and casein or soy protein as the sole protein. A group of 10 animals were fed for 42 days with CH-F/casein and then for a further 50 days with standard food.
After removal of the aorta, cross-sections were prepared, HE-stained and evaluated automatically with a computerized image-analyzer. The relative plaque length and lumen occlusion of the different groups were compared. We found in the casein fed animals a higher grade of atherosclerosis than in the soy protein fed animals. After discontinuing the cholesterol supplement to the diet, we found that the plaques continued to increase in size over the subsequent 50 days. Relative plaque length and lumen occlusion in this group were similar to these in the group fed CH-F/Sojamin for 90 days.
Zusammenfassung
ANITSCHKOW beschrieb 1913 die Induktion von Plaques in der Kaninchenaorta durch Cholesterinzusatz zum Futter dieser Tiere [1]. Seither dient das hypercholesterinämische Kaninchen als Modell für die Analyse der Pathogenese und -physiologie der Atherosklerose [4, 6]. Es zeigte sich, daß die Progredienz der Plaques stark variiert. Als ursächlich für diese Variationen wurden u.a. die Cholesterinmenge im Futter und die Dauer der Cholesteringabe diskutiert [3, 7]. In unserer Studie untersuchten wir den Einfluß der Fütterungsdauer mit einem cholesterinangereicherten Futter und die Wirkung verschiedener Proteine als Nahrungszusätze auf die Progression der atherosklerotischen Plaques in weißen Neuseeland(NZW)-Kaninchen.
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Literaturverzeichnis
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© 1992 Springer Fachmedien Wiesbaden
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Pagenstecher, A., Skatulla, L., Tran, N., Gorniak, R., Metz, J., Pill, J. (1992). The influence of cholesterol in the diet on the progression of atherosclerosis in the aorta of rabbits. In: Heinle, H., Schulte, H., Schaefer, H.E. (eds) Arteriosklerotische Gefäßerkrankungen. Vieweg+Teubner Verlag, Wiesbaden. https://doi.org/10.1007/978-3-663-19646-4_36
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DOI: https://doi.org/10.1007/978-3-663-19646-4_36
Publisher Name: Vieweg+Teubner Verlag, Wiesbaden
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Online ISBN: 978-3-663-19646-4
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