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Probleme und aktueller Stand der Angina pectoris-Therapie

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Zusammenfassung

Bei der Therapie der Angina pectoris besteht Anlaß, eine ganze Reihe von Fragen neu zu diskutieren. In Tabelle 1 sind derartige Problemkreise aufgeführt, die hier besprochen werden sollen.

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Literatur

  1. Abrams, J.: The brief saga of transdermal nitroglycerin discs: Paradise lost? Am.J. Cardiol. 1984, 54, 220–224

    Article  PubMed  CAS  Google Scholar 

  2. Amsterdam, E.A., Martschinske, R., Laslett, L.J. et al.: Symptomatic and silent myocardial ischemia during exercise testing in coronary artery disease. Am.J. Cardiol. 1986, 58, 43B–46B.

    Article  Google Scholar 

  3. v. Arnim, Th.: ST-Segment-Analyse im Langzeit-EKG. Dtsch med. Wschr. 1985, 26, 1047

    Article  Google Scholar 

  4. Assey, M.E., Walters, G.L., Hendrix, G.H. et al.: Incidence of acute myocardial infarction in patients with exercise-induced silent ischemia. Am.J. Cardiol. 1987, 59, 497–500

    Article  PubMed  CAS  Google Scholar 

  5. Bassan, M.M., Weiler-Ravell, D.: Effect of twelve-hour hiatus in propranolol therapy on exercise tolerance in patients with angina pectoris. Am. Heart J. 1983, 105, 234–239

    Article  PubMed  CAS  Google Scholar 

  6. Beyerle, A., Reiniger, G., Rudolph, W.: Ausgeprägter antianginöser und antiischämischer Effekt unter Langzeitbehandlung mit Molsidomin: Kein Anhalt für Toleranzentwicklung. Z. Kardiol. 75, 93, 1986

    Google Scholar 

  7. Blasini, R., Reiniger, G., Brügmann, U., Rudolph, W.: Vermeidung einer Toleranzentwicklung unter Isosorbiddinitrat durch Intervalltherapie, Herz 1984, 9, 166–170

    PubMed  CAS  Google Scholar 

  8. Brown, B.G., Lee, A.B., Bolson, E.L., Dofge, H.T.: Reflex constriction of significant coronary stenosis as a mechanism contributing to ischemic left ventricular dysfunction during isimetric exercise. Circulation 1984, 70, 18

    Article  PubMed  CAS  Google Scholar 

  9. Cairns, J.A., Gent, M., Singer, J. et al.: Aspirin, Sulfinpyrazone or both in unstable angina. New Engl. J. Med. 1985, 313, 1369–1375

    CAS  Google Scholar 

  10. Campbell, S., Barry, J., Rebessa, G. et al.: Active transient myocardial ischemia during daily life in asymptomatic patients with positive exercise tests and coronary artery disease. Am. J. Cardiol. 1986, 57, 1010–1016

    Article  PubMed  CAS  Google Scholar 

  11. CASS principal investigators: Coronary artery surgery study (CASS): A randomized trial of coronary artery bypass surgery. Circulation 1983, 68, 939–950

    Article  Google Scholar 

  12. Christopher, T.D., Konstantinow, G., Jones, R.H.: Bayesian analysis of data from radionuclide angiocardiograms for diagnosis of coronary artery disease. Circulation 1984, 69, 65–72

    Article  PubMed  CAS  Google Scholar 

  13. Cohen, M., Fuster, V.: Unstable angina: Is it time for more aggresive Therapy? Europ. Heart J. 1986, 7, 1014–1015

    Google Scholar 

  14. Conn, P.F.: Prognostic significance of asymptomatic coronary artery disease. Am. J. Cardiol. 1986, 58, 51B–56B

    Article  Google Scholar 

  15. Come, PC, Bitt, B.: Nitroglycerin-induced severe hypotension and bradycardia in patients with acute myocardial infarction. Circulation 1976, 54, 624–628

    Article  PubMed  CAS  Google Scholar 

  16. Deanfield, J.E., Shea, M.J., Selwyn, A.P.: Clinical evaluation of transient myocardial ichemia during daily life in patients with stable angina: Its, Am. J. Med. 1985, 79 Suppl. 3A, 18–24

    Article  PubMed  CAS  Google Scholar 

  17. Deanfield, J.E., Shea M., Wilson, R.A. et al.: Direct effects of smoking on the heart: Silent ischemic disturbances of coronary flow. Am. J. Cardiol. 1986, 57, 1005

    Article  PubMed  CAS  Google Scholar 

  18. De Busk, R., Blomqvist, C.G., Koechoukas, N.T. et al.: Identification and treatment of low risk patients after acute myocardial infarction and coronary-artery bypass graft surgery. New Engl. J. Med. 1986, 314, 161–166

    Article  Google Scholar 

  19. Diamond, G.A., Forrester, J.S.: Analysis of probability as an aid in the clinical diagnosis of coronary artery disease. New Engl. J. Med. 1979, 300, 1350–1358

    Article  PubMed  CAS  Google Scholar 

  20. Erikssen, J., Thaulow, E.: Follow-up of patients with asymptomatic myocardial ischemia. In: Rutishauser, W., Roskamm, H. (eds): Silent myocardial Ischemia. Berlin-Heidelberg-New York — Tokyo (Springer) 1984, p. 156–164

    Chapter  Google Scholar 

  21. Fitzgerald, D.J., Roy, L., Catella, F. et al.: Platelet activation in unstable coronary disease, New Engl. J. Med. 1986, 3125, 983–989

    Article  Google Scholar 

  22. Flessas, M.R., Ryan, C.K.: Elevation of left ventricular filling pressure resulting from isometric exercise in ischemic heart disease. Am. Heart J. 1983, 105, 339–342

    Article  Google Scholar 

  23. Fuster, V., Chesebro, J.H.: Mechanism of unstable angina. New Engl. J. Med. 1986, 315, 1023–1025

    Article  PubMed  CAS  Google Scholar 

  24. Gage, J.E., Hess, O.M., Murakami, T., Ritter, M., Grimm, J., Krayenbühl, P.: Vasoconstriction of stenotoc coronary arteries during dynamic exercise in patients with classic angina pectoris: Reversibility by nitroglycerin, Circulation 1986, 73, 865–876

    Article  PubMed  CAS  Google Scholar 

  25. Goldstein, S., Medendorp, S.V., Landis, J.R. et al.: Analysis of cardiac symptoms preceeding cardiac arrest. Am. J. Cardiol. 1986, 58, 1195–1198

    Article  PubMed  CAS  Google Scholar 

  26. Gottlieb, S.O., Weisfeldt, M.L., Ouyang, P. et al.: Silent ischemia as a marker for early unfavourable outcomes in patients with unstable angina New. Eng. J. Med. 1986, 314, 1214–1219

    Article  PubMed  CAS  Google Scholar 

  27. Higginbotham, M.B., Morris, K.G., Coleman, R.E., Cobb, F.R.: Comparison of Nifedipine alone with Propranolol alone for stable angina pectoris including hemodynamics at rest and during exercise. Am. J Cardiol. 1986, 57, 1022–1028

    Article  PubMed  CAS  Google Scholar 

  28. The HINT research group: Report of the Holland interuniversity Nifedipine Metoprolol trial (HINT) research group: Early treatment of unstable angina in the coronary care unit: A randomized, double blind, placebo controlled comparison of recurrent ischemia in patients treated with Nifedipine or metoprolol or both. Brit. Heart J. 1986, 56, 400–413

    Article  Google Scholar 

  29. Hollenstein, U., Blümchen, G.: Die medikamentöse Therapie der koronaren Herzerkrankung. J. Am. Med. Ass., dtsch. Ausg., 1986, 524–526

    Google Scholar 

  30. Holmes, D.R., Davis, K.B., Mock, M.B. et al.: The CASS study: The effect of medical and surgical treatment on subsequent sudden cardiac death in patients with coronary artery disease: A report from the coronary artery surgery study. Circulation 1986,73, 1254–1263

    Article  PubMed  Google Scholar 

  31. Hugenholtz, P.G.: Unstable angina revisited once more. Europ. Heart J. 1986, 7, 1010–1013

    CAS  Google Scholar 

  32. Hugenholtz, P.G., Serruys, P.W., Fleckenstein, A., Nayler, W.: Why Ca antagonists will be most useful before or during early myocardial ischemia and not after infarction has been established. Europ. Heart J. 1986, 7, 270–278

    CAS  Google Scholar 

  33. Kannel, W.B., Abbott, R.D.: Incidence and prognosis of unrecognized myocardial infarction: An update on the Framingham study. New Engl. J. Med. 1984, 311, 1144–1147

    Article  PubMed  CAS  Google Scholar 

  34. Kenedy, P.: Intraindividuelle Dosis-Wirkungsbeziehung von Elantan long. In: Borchard, U., Raffleinbeul, W., Schrey, A. (eds): Mononitrat. München (Dr. C.Wolf Verlag) 1985, pp. 108–115

    Google Scholar 

  35. Lawrence, J.R., Sheherd, J.T., Bone, I. et al.: Fibrinolytic therapy in unstable angina pectoris: A controlled trial. Thromb. Res. 1980, 17, 1767–1777

    Article  Google Scholar 

  36. Leon, M.B., Rosing, D.R., Bnow, R.O. et al.: Clinical efficacy of Verapamil alone and combined with propranolol in treating patients with chronic stable angina pectoris. Am. J. Cardiol. 1981, 48, 131–139

    Article  PubMed  CAS  Google Scholar 

  37. Lewis, H., Davis, J., Archibald, D. et al.: Protective effects of aspirin against myocardial infarction and death in man with unstable angina. New Engl. J. Med. 1983, 309, 396–403

    Article  PubMed  Google Scholar 

  38. Maetzel, F.-K., Castedello, Th.: Stress-Ergometrie. Herz/Kreislauf 1986, 329–336

    Google Scholar 

  39. MRFIT, Multiple Risk Factor Intervention Trial Research Group: Exercise electrocardiogram and coronary heart disease mortality. Am. J. Cardiol. 55, 15, 1985

    Google Scholar 

  40. Muller, J.E., Turi, Z.G., Pearle, D.L. et al.: Nifedipine and concentional therapy for unstable angina pectoris: A randomized double blind comparison. Circulation 1984 ,69, 728–739

    Article  PubMed  CAS  Google Scholar 

  41. The Multifactor Postinfarction Research group: Risk stratification and survival after myocardial infarction. New Engl. J. Med. 1983, 309, 331–336

    Google Scholar 

  42. Nademanee, K., Intarachot, V., Piontek, M. et al.: Silent myocardial ischemia in exercise-induced angina: on Holter: Has it clinical significance? Circulation 1984, 70, Suppl. 11, 451

    Article  Google Scholar 

  43. Nademanee, K., Intarachot, V., Singh, P.N. et al.: Characteristics and clinical significance of silent myocardial ischemia in unstable angina. Am.J. Cardiol. 1986, 58, 26B–35B

    Article  Google Scholar 

  44. Pepine, C.J., Feldman, R.L., Ludbrook, P. et al.: Left ventricular dyskinesia reversed by intravenous Nitroglycerin: A manifestation of silent myocardial ischemia. Am. J. Cardiol. 1986, 58, 38B–42B

    Article  Google Scholar 

  45. Quyyumi, A.A., Efthimiou, J., Quyyumi, A. et al.: Nocturnal angina: precipitating factors in patients with coronary artery disease and those with variant angina. Brit. Heart. J. 1986, 56, 346–352

    Article  PubMed  CAS  Google Scholar 

  46. Riecker, G.: Stumme Myokardischämie. Arzneimitteltherapie 4, 181–183, 1986

    Google Scholar 

  47. Robertson, R.M., Wood, A.J.J., Vaughn, W.K., Robertson, D.: Exacerbation of vasotonic angina pectoris by propranolol. Circulation 1982, 65, 281–285

    Article  PubMed  CAS  Google Scholar 

  48. Rosoff, M.H., Cohen, M.V.: Profound bradycardia after amylnitrite in patients with a tendency to vasovagal episodes. Brit. Heart. J. 1986, 55, 97–100

    Article  PubMed  CAS  Google Scholar 

  49. Rudolph, W., Dirschinder, J., Kraus, F.: Medikamentöse Behandlung der Angina pectoris. Med. Welt 1986, 431–437

    Google Scholar 

  50. Schneider, W., Stahl, B., Bussmann, W.D., Kaltenbach, M.: Long term effects of high-dose ISDN therapy in patients with coronary heart disease. In: M. Kaltenbach, G. Kober (eds): Nitrates and nitrate tolerance in angina pectoris. Darmstadt (Steinkopf-Verlag) 1983, pp. 131–137

    Chapter  Google Scholar 

  51. Scholl, J.M., Benacerraf, A., Ducimetiere, P. et al.: Comparison of risk factors in vasospastic angina without significant fixed coronary narrowing to significant fixed coronary narrowing and no vasospastic angina. Am. J. Cardiol. 1986, 57, 199–202

    Article  PubMed  CAS  Google Scholar 

  52. Selwyn, A.P., Shea, M., Deanfield, J.E. et al.: Character of transient ischemia in angina pectoris. Am. J. Cardiol. 1986, 58, 21B–25B

    Article  Google Scholar 

  53. Sherman, C.T., Litvack, F., Grundfest, W. et al.: Coronary angioskopy in patients with unstable angina pectoris. New Engl. J. Med. 1986, 315, 913–919

    CAS  Google Scholar 

  54. Silber, S.: Nitrattoleranz. Dtsch. med. Wschr. 1984, 109, 1124–1132

    Article  PubMed  CAS  Google Scholar 

  55. Silber, S.: Wann ist ein Patient mit koronarer Herzerkrankung optimal behandelt? Internist 1986, 27, 525–540

    PubMed  CAS  Google Scholar 

  56. Silber, S.: Nitrat-Therapie. Herz + Gefäße 1986, 9, 372–380

    Google Scholar 

  57. Silber, S.: Nitrattoleranz: Induktion, sinnvolle Vermeidung und Konsequenzen für eine Kombinationstherapie. Habil.schrift, München 1986

    Google Scholar 

  58. Silber, S.: Kann das Leben von Patienten mit koronarer Herzerkrankung verlängert werden? Dtsch. Ärztebl. 1986, 2084–2090

    Google Scholar 

  59. Silber, S., Krause, K.H., Garner, Ch., Theisen, K., Jahrmärker, H.: Anti-ischemic effects of an 80 mg tablet of isosorbide-dinitrate in sustained-release form before and after two weeks treatment with 80 mg once or twice daily. Z. Kardiol. 1983, 72, Suppl. 3, 211–217

    PubMed  Google Scholar 

  60. Silber, S., Vogler, A.: Die stumme Myokardischämie: Dimensionierung eines Problems. Intensivmedizin 1986, 23, 52–63

    Google Scholar 

  61. Silber, S., Vogler, A., Spiegelsberger, F., Theisen, K.: Zuverlässige Erkennung von ST-Strecken-Veränderungen im Langzeit-EKG in Ruhe und während Belastung. Klin. Wschr. 1986, 64, Suppl. V., 117–118

    Google Scholar 

  62. Silber, S., Vogler, A., Theisen, K.: Problems of anti-ischemic drug therapy in patients with insufficient nitrate response. J. Am. Coll. 1986, 7, 28A

    Google Scholar 

  63. Silber, S., Vogler, A., Theisen, K.: Equal anti-ischemic properties of isosorbide dinitrate plus verapamil and isosorbide dinitrate plus propranolol. A randomized double blind and crossover study. Z. Kardiol. 1986, 75, Suppl. 3, 100–105

    PubMed  Google Scholar 

  64. Singh, B.N., Nademanee, K., Figueras, J., Josephson, M.A.: Hemodynamic and electrocardiographic correlates of symptomatic and silent myocardial ischemia: Pathophysiology and therapeutic implications. Am. J. Cardiol. 1986, 58, B3–B10

    Article  Google Scholar 

  65. Subramanian, V.B.: Clinical and research application of ambulatory Holter ST-segment and heart rate monitoring. Am. J. Cardiol. 1986, 58, 11B–20B

    Article  Google Scholar 

  66. Subramanian, V.B., Bowles, M.J., Davies, A., Raftery, E.B.: Combined therapy with verapamil and propranolol in chronic stable angina. Am. J. Cardiol. 1982, 49,125–132

    Article  PubMed  CAS  Google Scholar 

  67. Subramanian, V.B., Bowles, M.J., Khurmi, N.S. et al.: Randomized double-blind comparison of verapamil and nifedipine in chronic stable angina. Am. J. Cardiol. 1982, 50, 696–703

    Article  PubMed  CAS  Google Scholar 

  68. Symposion coronary artery disease: Prevention of thrombosis following angioplasty, bypass, infarction, Lysis. München, Jan. 24.–25., 1986

    Google Scholar 

  69. Telford, A., Wilson, C: Trial of heparin versus atenolol in prevention of myocardial infarction in the intermediate coronary syndrom. Lancet, 1981, 1, 1225–1228

    Article  PubMed  CAS  Google Scholar 

  70. Theisen, K., Angermann, Ch., Silber, S., Weber, M., Jahrmärker, H.: Überflüssige kardiologische Diagnostik. Internist 1986, 27, 552–565

    PubMed  CAS  Google Scholar 

  71. Timolol study. Norwegian multicenter study group: Timolol induced reduction in mortality and reinfarction in patients surviving acute myocardial infarction. New Engl. J. Med. 1981, 305, 801–807

    Google Scholar 

  72. Tzivoni, D., Gavish, A., Benhorin, J. et al.: Myocardial ischemia during daily activities and stress. Am. J. Cardiol. 1986, 58, 47B–50B

    Article  Google Scholar 

  73. Usitalo, A., Arstila, M., Bae, E.A. et al.: Metoprolol, Nifedipine, and the combination in stable effort angina. Am. J. Cardiol. 1986, 57, 733–737

    Article  Google Scholar 

  74. Vogler, A., Spiegelsberger, F., Silber, S., Theisen, K.: Placebokontrollierte Beurteilung von Wirkungsausmaß und -dauer einer 120 mg Kapsel Isosorbiddinitrat (ISDN)-retard. Z. Kardiol. 1986, 75, 81

    Google Scholar 

  75. Weber, M.A., v. Schacky, C, Lorenz, R. et al.: Niedrig dosierte Acetylsalizylsäure nach aortokoronarer Bypassoperation. Klin. Wschr. 1984, 62, 458–464

    Article  PubMed  CAS  Google Scholar 

  76. Weber, M.A.: Koronare Herzerkrankung: Verhinderung von Progression und Rezidiv nach revascularisierenden Interventionen durch antithrombotische Therapie. Habil. schritt, München 1987

    Google Scholar 

  77. Winniford, M., Fulton, K.L., Corbett, J.R. et al.: Propranolol-Verapamil versus Propranolol-Nifedipine in severe angina pectoris of effort: A randomized, double blind, crossover study. Am. J. Cardiol. 1985, 55, 281–285

    Article  PubMed  CAS  Google Scholar 

  78. Winniford, M.D., Gabliani, G., Johnson, S.M. et al.: Concomitant calcium antagonist plus isosorbide dinitrate therapy for markedly active variant angina. Am. Heart. J. 1984, 108, 1269–1278

    Article  PubMed  CAS  Google Scholar 

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© 1988 Springer Fachmedien Wiesbaden

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Jahrmärker, H. (1988). Probleme und aktueller Stand der Angina pectoris-Therapie. In: Herz- und Kreislauferkrankungen. Vieweg+Teubner Verlag, Wiesbaden. https://doi.org/10.1007/978-3-663-14091-7_1

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  • DOI: https://doi.org/10.1007/978-3-663-14091-7_1

  • Publisher Name: Vieweg+Teubner Verlag, Wiesbaden

  • Print ISBN: 978-3-528-07947-5

  • Online ISBN: 978-3-663-14091-7

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