Advertisement

Serum-Kreatinin, Messung und Aussagekraft

  • R. Baethke
Chapter
  • 17 Downloads

Zusammenfassung

Kreatinin (2-Imino-l-Methylimazolidin-4-on) ist ein spontan, d. h. nicht-enzymatisch entstehendes Umwandlungsprodukt des Kreatins bzw. Kreatinphosphats, dessen Bildung ein konstantes Verhältnis zum Gesamtkreatin aufweist [1]. Seine Elimination erfolgt überwiegend renal — wenngleich nicht ausschließlich [2]; die Ausscheidung ist somit der Muskelmasse annähernd proportional und gilt üblicherweise als eine „individuelle Konstante“ des Menschen [3].

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Referenzen

  1. [1]
    Crim, M. C., Calloway, D. S. M., and Margen, S.: Creatinine metabolism in men: creatine pool size and turnover in relation to creatine intake. J. Nutr. 106: 371 (1976).Google Scholar
  2. [2]
    Mitch, W. E., and Walser, M.: A proposed mechanism for reduced creatinine excretion in severe chronic renal failure Nephron 21: 248 (1978).PubMedCrossRefGoogle Scholar
  3. [3]
    Karlson, P.: Kurzes Lehrbuch der Biochemie. Thieme-Verlag, 9. Aufl., Stuttgart 1974.Google Scholar
  4. [4]
    Doolan, P. D., Alpen, E. L., and Theil, G. B.: A clinical appraisal of the plasma concentration and endogenous clearance of creatinine. Amer. J. Med. 32: 65 (1962).PubMedCrossRefGoogle Scholar
  5. [5]
    Schirmeister, J., Willmann, H., Kiefer, H., und Hallauer, W.: Für und wider die Brauchbarkeit der endogenen Kretininclearance in der funktioneilen Nierendiagnostik. Dtsch. Med. Wschr. 89: 1640 (1964).PubMedCrossRefGoogle Scholar
  6. [6]
    Heierli, CH., THölen, H., und Bartels, H.: Schätzung des Glomerulusfiltrats durch das Serumkreatinin. Dtsch. Med. Wschr. 97: 67 (1972).PubMedCrossRefGoogle Scholar
  7. [7]
    Hierholzer, K., Butz, M., and Baethke, R.: Evaluation of reduced glomerular filtration rate in the severely diseased kidney in: Uremia (Eds. Kluthe, R., Berlyne, G., and Burton, B.), Thieme-Verlag, Stuttgart 1972.Google Scholar
  8. [8]
    Morgan, D. B., Dillon, S., and Payne, R. B.: The assessment of glomerular function: creatinine clearance or plasma creatinine? Postgrad. Med. J. 54: 302 (1978).Google Scholar
  9. [9]
    Chinn, E. K., Batsakis, J. G., Pilon, H., and Delbecg, K.: Serum creatinine, A Cap survey. Amer. J. Clin. Path. 70 (No. 3, Suppl): 503 (1978).Google Scholar
  10. [10]
    Weatherburn, M. W., Trotman, R. B. B., and Jackson, S. H.: Specific method for serum creatinine determination based on ion exchange chromatography and an automated alkaline picrate reaction — a proposed reference method. Clin. Biochem. 11: 159 (1978).PubMedCrossRefGoogle Scholar
  11. [11]
    Kassenärztliche Vereinigung Niedersachsen, 33. Ringversuch. Deutsche Gesellschaft für klinische Chemie e.V., Mai 1979.Google Scholar
  12. [12]
    Butler, A. R., Vasiliades, J.: Jaffé reaction mechanism debated (Letters to the editor). Clin. Chem. 23: 613 (1977).PubMedGoogle Scholar
  13. [13]
    Blass, K. G., Thibert, R., and Lam, L. K.: A study of the mechanism of the Jaffé reaction. J. Clin. Chem. Clin. Biochem. 12: 336 (1974).Google Scholar
  14. [14]
    Young, D. S., Pestaner, L. C., and Gibberman, V.: Effects of drugs on clinical laboratory tests. Clin. Chem. 21: 1D–432 D (April 1975).PubMedGoogle Scholar
  15. [15]
    Cook, J. G. H.: Factors influencing the assay of creatinine. Ann. Clin. Biochem. 12: 219 (1975).PubMedGoogle Scholar
  16. [16]
    Dubos, R., and Miller, B.: Determination by a specific enzymatic method of creatinine content of blood and urine of normal and nephritic patients. J. Biol. Chem. 121: 457 (1937).Google Scholar
  17. [17]
    Tanzer, M. L., and Gilwarg, C.: Creatine and creatine kinase measurement. J. Biol. Chem. 234: 3201 (1959).PubMedGoogle Scholar
  18. [18]
    Wahlefeld, A. W., Herz, G., and Bergmeyer, H. U.: A completely enzymatic determination of creatinine in human sera or urine. Scand. J. Clin. Lab. Invest. 29: Suppl 126, Abstract 30.1 (1972).Google Scholar
  19. [19]
    Moss, G. A., Bondar, R. J. L., and Buzelli, D. M.: Kinetic enzymatic method for determining serum creatinine. Clin. Chem. 21: 1422 (1975).PubMedGoogle Scholar
  20. [20]
    Meyerhoff, M., and Rechnitz, G. A.: An activated enzyme electrode for creatinine. Anal. Chim. Acta 85: 277 (1976).PubMedCrossRefGoogle Scholar
  21. [21]
    Chiu, W. L., Gadalla, M. A. F., and Peng, G. W.: Simple, rapid and micro high pressure liquid Chromatographic determination of endogenous „true“ creatinine in plasma, serum, and urine. J. Pharm. Sci. 67: 182 (1978).CrossRefGoogle Scholar
  22. [22]
    Lim, C. K., Richmond, W., Robinson, D. P., and Brown, S. S.: Towards a definite assay of creatinine in serum and in urine: separation by high pressure performance liquid chromatography. J. Chromatography 145: 41 (1978).Google Scholar
  23. [23]
    BJörkhem, J., Blomstrand, R., and öhman, G.: Mass fragmentography of creatinine proposed as a reference method. Clin. Chem. 23: 2114 (1977).PubMedGoogle Scholar
  24. [24]
    Knoll, E., Rebel, F. C., und Wisser, H.: Kinetische Kreatininbestimmung mit dem Gemsaec-Fast-Analyser. Methodenvergleich mit der Fuller-Erde-Methode. J. Clin. Chem. Clin. Biochem. 16: 239 (1978).PubMedGoogle Scholar
  25. [25]
    Wahlefeld, A. W.: Persönliche Mitteilung. August 1979.Google Scholar
  26. [26]
    Knoll, E., Wisser, H., und Rebel, F. C.: Abhängigkeit der Konzentrationen von Kreatinin und Harnstoff im Serum von der Tageszeit bei normaler und eingeschränkter Nierenfunktion. J. Clin. Chem. Clin. Biochem. 16: 567 (1978).PubMedGoogle Scholar
  27. [27]
    Schwartz, G. J., Haycock, G. B., and Spitzer, A.: Plasma creatinine and urea concentration in children: normal values for age and sex. J. Pediatr. 88: 828 (1976).PubMedCrossRefGoogle Scholar
  28. [28]
    Donckerwolcke, R. A. M. G., Sander, P. C., Von Stekelenburg, G. J., Stoop, J. W., and Tiddens, H. A. W. M.: Serum creatinine values in healthy children. Acta Paediatr. Scand. 59: 399 (1970).PubMedCrossRefGoogle Scholar
  29. [29]
    Ahlert, G., Bruschke, G., Dietze, F., Franke, H., und Haase, J.: Altersabhängige Veränderungen und normale Schwankungen der Kreatin-und Kreatininausscheidung. Z. Altersforsch. 20: 113 (1967).Google Scholar
  30. [30]
    Kampmann, J. P., Siersbaeck-Nielsen, K., Kristensen, M., and Molholm-Hansen, J.: Aldersbetingede variationer i urinkreatinin og endogen kreatininclearance. Ugeskr. Laeger 133: 2369 (1971).PubMedGoogle Scholar
  31. [31]
    Rowe, J. W., Andres, R., Tobin, J. D., Norris, A. H, and Shock, N. W.: The effect of age on creatinine clearance in men: a cross sectional and longitudinal study. J. Gerontol. 31: 155 (1976).PubMedCrossRefGoogle Scholar
  32. [32]
    Vestal, R. E.: Drug use in the elderly: a review of problems and special considerations. Drugs 16: 358 (1978).PubMedCrossRefGoogle Scholar
  33. [33]
    Wesson, L. G.: Physiology of the human kidney. Grune & Stratton, New York and London 1969.Google Scholar
  34. [34]
    Forbes, G. B., and Bruining, G. J.: Urinary creatinine excretion and lean body mass. Amer. J. Clin. Nutr. 29: 1359 (1976).PubMedGoogle Scholar
  35. [35]
    Haugen, H. N., and Blegen, E. M.: Plasma „creatinine“ concentration and creatinine clearance in clinical work. Ann. Int. Med. 43: 731 (1935).Google Scholar
  36. [36]
    Effersöe, P.: Relationship between endogenous 24-hour creatinine clearance and serum creatinine concentration in patients with chronic renal disease. Acta Med. Scand. 156: 429 (1957).PubMedCrossRefGoogle Scholar
  37. [37]
    Mertz, D. P., Sarre, H., und Cremer, Z.: Über den diagnostischen Wert semiquantitativer Nierenfunktionsproben. I. Korrelation zwischen der Plasmakonzentration von „wahrem“ endogenem Kreatinin und Inulinclearance. Klin. Wschr. 40: 687 (1962).PubMedCrossRefGoogle Scholar
  38. [38]
    BRöchner-Mortensen, J., Jensen, S., and Rödbro, P.: Assessment of renal function from plasma creatinine in adult patients. Scand. J. Urol. Nephrol. 11: 263 (1977).PubMedCrossRefGoogle Scholar
  39. [39]
    Höffler, D.: Antibakterielle Therapie bei Niereninsuffizienz. Beecham Pharma, Mainz 1971.Google Scholar
  40. [40]
    Robson, M. D.: Estimation of creatinine clearance. Ann. Int. Med. 82: 125 (1977).Google Scholar
  41. [41]
    Jelliffe, R. W.: Creatinine clearance. Bedside estimate. Ann. Int. Med. 79: 604 (1973).CrossRefGoogle Scholar
  42. [42]
    Cockroft, D. W., and Gault, M. H.: Prediction of creatinine clearance from serum creatinine. Nephron 16: 31 (1976).CrossRefGoogle Scholar
  43. [43]
    Chyský, V., und Pütter, J.: Aminoglykosid-Antibiotika bei Patienten mit eingeschränkter Nierenfunktion: ein Dosierungsrechner für die Klinik. Klinikarzt 8: 56 (1979).Google Scholar
  44. [44]
    Kampmann, J., Siersbaek-Nielsen, K., Kristensen, M., and Mölholm-Hansen, J.: Rapid evaluation of creatinine clearance. Acta Med. Scand. 196: 517 (1974).PubMedCrossRefGoogle Scholar
  45. [45]
    Mawer, G. E.: Computer assisted prescribing of drugs. Clin. Pharmacokinetics 1: 67 (1976).CrossRefGoogle Scholar
  46. [46]
    Schwartz, G. J., Haycock, G. B., Edelmann, C. M., and Spitzer, A.: A simple estimate of glomerular filtration rate in children derived from body length and plasma creatinine. Pediatr. 58: 259. (1976).Google Scholar
  47. [47]
    Counahan, R., Chantler, C., Ghazali, S., Kirkwood, B., Rose, F., and Barratt, T. M.: Estimation of glomerular filtration rate from plasma creatinine concentration in children. Arch. Dis. Child. 51: 857 (1976).Google Scholar
  48. [48]
    Shull, B. C., Haughey, D., Koup, J. R., Baliah, T., and Li, P. K.: A useful method for predicting creatinine clearance in children. Clin. Chem. 24: 1167 (1978).PubMedGoogle Scholar
  49. [49]
    Schwab, M.: Methodik und Indikation moderner Nierenfunktionsprüfungen. Verh. Dtsch. Ges. Inn. Med. 1963: 299.Google Scholar
  50. [50]
    Bastl, C., Katz, M. A., and Shear, L.: Uremia with low serum creatinine — and entity produced by marked creatinine secretion. Amer. J. Med. Sci 273: 289 (1977).PubMedGoogle Scholar
  51. [51]
    BRäutigam, M., Froese, P., Baethke, R., und Kessel, M.: Zur Kreatininausscheidung beim Menschen nach Gabe von Co-Trimoxazol. Klin. Wschr. 57: 95 (1979).PubMedCrossRefGoogle Scholar
  52. [52]
    Steiness, E.: Increased serum creatinine without change in renal function during treatment with amilorid hydrochloride in: Diuresis, Kaliuresis and Hypertension (Ed.: B. Magnani). Futura Publ. Comp., New York 1977.Google Scholar
  53. [53]
    Selkurt., E. E., Wathen, R. L., and Santos-Martinez: Creatinine excretion in the squirrel monkey (Saimiri Sciureus). Fed. Proc. 26: 266 (1967).Google Scholar
  54. [54]
    Richards, R. K., Bjornosson, T. D., and Waterbury, L. D.: Rise in serum and urine creatinine after phenacemide. Clin. Pharmacol. Ther. 23: 430 (1978).PubMedGoogle Scholar
  55. [55]
    Arisz, L., Donker, A. J. M., Brentjens, J. R. H.: The effect of indomethacin on proteinuria and kidney function in the nephrotic syndrome. Acta Med. Scand. 199: 121 (1976).PubMedCrossRefGoogle Scholar
  56. [56]
    Kimberley, R. P. and Plotz, P. H.: Correspondence: Aspirin and renal function. New Engl. J. Med. 296: 1169 (1977).CrossRefGoogle Scholar
  57. [57]
    Mitch, W. E., Buffington, G. A., Lemann, J., and Walser, M.: A simple method of estimating progression of chronic renal failure. Lancet 1976/II: 1326.Google Scholar
  58. [58]
    Rutherford, W. E., Blondin, J., Miller, J. P., Greenwalt, A. S., and Vavra, J. D.: Chronic progressive renal disease: rate of change of serum creatinine concentration. Kidney Int. II: 62 (1977).CrossRefGoogle Scholar
  59. [59]
    Wichmann, H. E, Vlaho, M., Peitz, R., und Sieberth, H. G.: Erlaubt die mathematische Analyse der Änderung des Serumkreatinins oder der Clearance eine Aussage über die Prognose der Nierenerkrankung oder Effektivität einer Therapie? Verh. Dtsch. Ges. Inn. Med. 1978: 1272.Google Scholar
  60. [60]
    Talwalkar, Y. B., and Mandel, S.: Monitoring progress of chronic renal failure. Lancet 1977/I: 366.Google Scholar
  61. [61]
    Thommen, K., Dubach, N. C., und Sutter, A.: Mathematische Erfassung des Nierenfunktionsverlustes bei chronischem Nierenversagen. Dtsch. Med. Wschr. 102: 1038 (1977).PubMedGoogle Scholar
  62. [62]
    Leumann, E. P.: Progression of renal insufficiency in pédiatric patients: estimation from serum creatinine. Helv. Paediatr. Acta 33: 25 (1978).PubMedGoogle Scholar
  63. [63]
    Maher, J. F., Nolph, K. D., and Bryan, C. W.: Prognosis of advanced chronic renal failure. I. Unpredictability of survival and reversibility. Ann. Int. Med. 81: 43 (1974).CrossRefGoogle Scholar
  64. [64]
    Merck, E.: Klinisches Labor. 12. Aufl., Darmstadt 1974.Google Scholar
  65. [65]
    Szasz, G., und Börner, U.: Reference values for creatinine in serum established by a highly specific enzymatic method. Clin. Chem. 23: 1172 (1977).Google Scholar

Copyright information

© Springer Fachmedien Wiesbaden 1980

Authors and Affiliations

  • R. Baethke
    • 1
  1. 1.Abteilung für Nieren- und HochdruckkrankePeter Friedrich Ludwig HospitalOldenburgDeutschland

Personalised recommendations