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Grundlagen der Theophyllintherapie: Durchführung und Bewertung von Konzentrationsbestimmungen im Serum

  • A. H. Staib
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Zusammenfassung

Theophyllin (1,3-Dimethylxanthin) wurde als ein wirkungsbestimmender Inhaltsstoff der Blätter des Teestrauchs Ende des 19. Jahrhunderts isoliert und seine Struktur in der ersten Dekade des 20. Jahrhunderts aufgeklärt. Mit der Herstellung des Theophyllin-Aethylendiamin-Komplexes (Aminophyllin) wurde die Substanz infolge dessen besserer Löslichkeit intravenös einsetzbar. Die Indikationen ergeben sich aus dem Wirkungsprofil, das dem anderer in der Natur vorkommender Methylxanthine (Koffein, Theobromin) qualitativ entspricht:
  • Stimulation von Zns-Funktionen (vegetativ, motorisch, sensorisch und psychisch)

  • positiv inotrope und chronotrope Wirkung am Herzen

  • Relaxation der glatten Muskulatur (Atemwege, Gefäße, Intestinaltrakt und Urogenitalsystem)

  • diuretischer Effekt

  • Wechselwirkung mit anderen Pharmaka (so additive oder potenzierende Effekte zu Analgetika und Spasmolytika).

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Copyright information

© Springer Fachmedien Wiesbaden 1980

Authors and Affiliations

  • A. H. Staib
    • 1
  1. 1.Klinische PharmakologieKlinikum der J. W. G.-Universität Frankfurt/M.Frankfurt 70Deutschland

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