Abstract
The therapeutic value of lignocaine in acute myocardial infarction is still a subject of debate [1]. Some of the lack of success with this drug may arise from the use of inadequate dosage. Thus, several trials, such as those of Bennett et al [2] and Chopra et al [3], failed to show benefit, whereas relatively higher doses were used by Lie et al [4] who did report success in preventing ventricular fibrillation. However, this was achieved at the expense of a 15% incidence of toxicity, underlining the fact that the therapeutic index of lignocaine is low.
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Tucker, G.T., Bax, N.D.S., Lennard, M.S., Woods, H.F. (1980). Can lignocaine kinetics be predicted?. In: Rietbrock, N., Woodcock, B.G., Neuhaus, G. (eds) Methods in Clinical Pharmacology. Methods in clinical pharmacology, vol 1. Vieweg+Teubner Verlag, Wiesbaden. https://doi.org/10.1007/978-3-663-14027-6_30
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DOI: https://doi.org/10.1007/978-3-663-14027-6_30
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