Abstract
The hepatic first pass effect is defined as the elimination of a substance during its first passage of the liver. The systemic bioavailability is contingent on the route of administration. The hepatic first pass effect is dependent on the intrinsic hepatic clearance, liver blood flow and liver architecture (e. g. intra-hepatic shunts). Interestingly the phenomenon of the first-pass effect was alluded to as early as 1893, Figure 1.
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Literature
Breimer, D. D.: Pharmacokinetics of methohexitone following intravenous infusion in humans. Brit. J., Anaesth. 48, 643 (1976)
Bush, M. T., Berry, G., Hume, A.: Ultra-short-acting barbiturates as oral hypnotic agents in man. Clin. Pharmac. Therap. 7, 373 (1966)
Heusler, H., Epping, J., Heusler, S., Richter, E., Vermeulen, N. P. E., Breimer, D. D.: Simultaneous determination of blood concentrations of methohexital and its hydroxymetabolite by gaschromatography and identification of 4-hydroxymethohexital by GC-MS (in press)
Lehmann, Ch.: Das Ultrakurznarkotikum Methohexital. Anaesthesiology and Resuscitation 57. Springer-Verlag-Berlin—Heidelberg—New York (1972)
Levin, W., Sernatinger, E., Jacobsen, M., Kuntzman, R.: Destruction of cytochrome p 450 by secobarbital and other barbiturates containing ally! groups. Science 16, 1341 (1972)
Loo, J. C. K., Riegelman, S.: Assessment of pharmacokinetic constants from postinfusion blood curves obtained after i. v. infusion. J. Pharm. Sci. 59, 53 (1970)
Murphy, P. J.: Biotransformation of methohexital. Internat. Anaesthesol. Clinics 12, 139 (1974)
Omura, T., Sato, R.: The carban-monoxide-binding pigment of liver microsomes. J. biol. Chem. 239, 23 (1964)
Reutter, W., Lesch, R., Keppler, D., Decker, K.: Galactosamin-Hepatitis. Naturwiss. 55, 497 (1968)
Schaffner, H., Scharnbeck, H., Hutterer, F., Denk, H., Greim, H. A., Popper, H.: Mechanism of cholestasis: VII a-Naphtylisothiocyanate induced jaundice. Lab. Invest. 28, 231 (1973)
Schoene, B., Fleischmann, R. A., Remmer, H., Oldershausen, H. F. v.: Determination of drug metabolizing enzymes in needle biopsies of human liver. Europ. J. clin. Pharmacol. 4, 565 (1972)
Welles, J. S., Mc Mahan, R. E., Doran, W. J.: The metabolism and excretion of Methohexital in the rat and dog. J. Pharmacol. Exp. Therap. 139, 166 (1962)
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© 1980 Springer Fachmedien Wiesbaden
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Epping, J., Heusler, H., Brachtel, D., Richter, E. (1980). First pass pharmacokinetics of methohexital in experimental liver disease of the rat. In: Rietbrock, N., Woodcock, B.G., Neuhaus, G. (eds) Methods in Clinical Pharmacology. Methods in clinical pharmacology, vol 1. Vieweg+Teubner Verlag, Wiesbaden. https://doi.org/10.1007/978-3-663-14027-6_29
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DOI: https://doi.org/10.1007/978-3-663-14027-6_29
Publisher Name: Vieweg+Teubner Verlag, Wiesbaden
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