Abstract
Aminoglycoside antibiotics play an important role in the treatment of infections with gram-negative bacteria. Gentamicin and tobramycin have been extensively used for several years, and more recently amikacin, sisomicin, and netilmicin were introduced to widen our therapeutic possibilities. These drugs are highly effective in septicemia and urinary tract infections, but their application is limited by a potential nephro-and ototoxicity. Much effort was therefore devoted to clarify the pharmacokinetic behaviour of aminoglycosides and to devise appropriate dosage regimens in different clinical situations. Measurement of serum levels was often recommended as a means to improve the safety of aminoglycoside treatment [1]. However, recent data on aminoglycosides [9, 13, 20] indicate that most of the previous studies did not completely describe the fate of these antibiotics in the human organism. The better understanding of aminoglycoside distribution and elimination is a direct consequence of an improved methodology for determination of drug levels and of a more refined data analysis. Therefore, it conforms to the subject of this symposium to review some of the problems connected with the use of these antibiotics and to discuss the practical importance of the currently proposed pharmacokinetic models.
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References
Barza, M., and Lauerman, M.: Why monitor serum levels of gentamicin? Clin. Pharmacokinetics: 3: 202–215 (1978)
Broughton, A., Strong, J. E., Pickering, L. K., and Bodey, G. P.: Radioimmunoassay of iodimated tobramycin. Antimicrob. Agents Chemother.: 10: 652–656 (1976)
Broughton, A., Strong, J. E., Pickering, L. K., Knight, J., and Bodey, G. P.: Radioimmunoassay and radioenzymatic assay of a new aminoglycoside antibiotic, netilmicin. Clin. Chem.: 24: 717–719 (1978)
Chauvin, J. M., Rudhardt, M., Blanchard, P., Gaillard, R., and Fabre, J.: Le comportement de la gentamicine dans le parenchyme rénale. Schweiz. Med. Wschr.: 108: 1020–1025 (1978)
Colburn, W. A., Schentag, J. J., Jusko, W. J., and Gibaldi M.: A model for prospective identification of the prenephrotoxic state during gentamicin therapy. J. Pharmacokin. Biopharm.: 6: 179–186 (1978)
Dettli, L.: Drug dosage in patients with renal disease. Clin. Pharmacol. Ther.: 16: 274–280 (1974)
Edwards, C. Q., Smith, C. R., Baughman, K. L., Rogers, J. F., and Lietman P.: Concentrations of gentamicin and amikacin in human kidneys. Antimicrob. Agents Chemother.: 9: 925–927 (1976)
Federspiel, P.: Zur Ototoxizität des Tobramycins. Infection, Suppl. 1: 50–57 (1975)
Follath, F., Spring, P., Wenk, M., Benelt, L. Z., and Dettli, L.: Comparative pharmacokinetics of sisomicin and netilmicin in healthy volunteers. In: Current Chemotherapy, Vol. II: pp. 997–980, Amer. Soc. Microbiology, Washington D.C., 1978
Holmes, R. K., and Sanford, J. P.: Enzymatic assays for gentamicin and related aminoglycoside antibiotics. J. Infect. Dis.: 129: 519–527 (1974)
Jahre, J. A., Fu, K. P., and Neu, H. C.: Kinetics of netilmicin and gentamicin. Clin. Pharmacol. Ther.: 23: 591–597 (1978)
Kahlmeter, G., Jonsson, S., and Kamme, C.: Multiple compartment pharmacokinetics of tobramycin. In: Current Chemotherapy, Vol. II, pp. 912–915, Amer. Soc. for Microbiology, Washington D. C. (1978)
Kahlmeter, G., Jonsson, S., and Kamme, C.: Longstanding posttherapeutic gentamicin serum and urine concentration in patients with unimpaired renal function. J. Antimicrob. Chemother.: 4: 132–152 (1978)
Kirby, W. M. M., Clarke, J. T., Libke, R. D., and Regamey, C.: Clinical pharmacology of amikacin and kanamycin. J. Infect. Dis.: 134: Suppl., 312–315 (1976)
Lode, H., Kemmerich, B., Koeppe, P., and Langmaack, H.: Vergleichende Pharmakokinetik und klinische Erfahrungen mit einem neuen Aminoglykosid-Derivat: Sisomicin. Dtsch. Med. Wschr.: 100: 2144–2150 (1975)
Mahon, W. A., Ezer, J., and Wilson, T. W.: Radioimmunoassay for measurement of gentamicin in blood. Antimicrob. Agents Chemother.: 3: 585–589 (1973)
Minishew, B. H., Holmes, R. K., and Baxter, C. R.: Comparison of a radioimmunoassay with and enzymatic assay for gentamicin. Antimicrob. Agents Chemother.: 7: 107–109 (1975)
Pechere, J. C., Dugal, R., and Pechere, M. M.: Kinetics of netilmicin in man. Clin. Pharmacol. Ther.: 23: 677–684 (1978)
Regamey, C., Gordon R., and Kirby, W. M.: Comparative pharmacokinetics of tobramycin and gentamicin. Clin. Pharmacol. Ther.: 14: 396–403 (1973)
Schentag, J. J., Jusko, W. J., Vance, J. W., Cumbo, T. J., Abrutyn, E., de Lattre, M., and Gerbracht, L.: Gentamicin disposition and tissue accumulation on multiple dosing. J. Pharmacokin. Biopharm.: 5: 559–577 (1977)
Schentag, J. J., Lasezkay, G., Cumbo, T., Plaut, M. E., and Jusko, W. J.: Accumulation pharmacokinetics of tobramycin. Antimicrob. Agents Chemother.: 13: 649–656 (1978)
Schentag, J. J., Plaut, M. E., Cerra, F. B., Wels, P. B., Walczak, P., and Buckley, R.: Aminoglycoside toxicity in critically ill surgical patients. J. Surg. Res.: 26: 270–279 (1979)
Smith, A. L., Waitz, J. A., Smith, D. H., Oden, E. M., and Emerson, B. B.: Comparison of enzymatic and microbiological gentamicin assays. Antimicrob. Agents Chemother: 6: 316–319 (1974)
Vozeh, S., Wenk, M., Spring, P., and Follath, F.: Verzögerte Ausscheidung der Aminoglykosid-Antibiotika: Bedeutung für die klinische Anwendung. Schweiz. Med. Wschr.: to be published (1979)
Watson, R. A. A., and Wenk, M.: New 1251 tracers in netilmicin and sisomicin radioimmunoassay. In: Current Chemotherapy, Vol. II, pp. 906–907, Amer. Soc. Microbiology, Washington D. C. (1978)
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© 1980 Springer Fachmedien Wiesbaden
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Follath, F., Spring, P., Vozeh, S., Wenk, M. (1980). Aminoglycoside antibiotics: problems and methods. In: Rietbrock, N., Woodcock, B.G., Neuhaus, G. (eds) Methods in Clinical Pharmacology. Methods in clinical pharmacology, vol 1. Vieweg+Teubner Verlag, Wiesbaden. https://doi.org/10.1007/978-3-663-14027-6_18
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DOI: https://doi.org/10.1007/978-3-663-14027-6_18
Publisher Name: Vieweg+Teubner Verlag, Wiesbaden
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