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Zusammenfassung der Vorträge

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Bildgebende Verfahren in der Neurologie und Psychiatrie

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Zusammenfassung

Glatirameracetat (GLAT, Synomina: Copolymer-1, COP-1; Copaxone®) ist ein synthetisches Tetrapeptid aus den 4 Aminosäuren L-Glutaminsäure, L-Lysin und L-Alanin, L-Tyrosin in zufälliger Mischungsreihenfolge. Die ursprüngliche Absicht bei der Entwicklung von GLAT in den 60er Jahren am Weizmann Institut in Rehovot (Israel) bestand darin, Peptide zu generieren, die den immunbiologischen Eigenschaften von basischem Myelinprotein (MBP) als vermutetem Antigen bei MS ähneln und eine experimentelle Encephalomyelitis (EAE) erzeugen können. Im Gegensatz dazu standen die konsekutiven In-vivoBefunde. Es zeigte sich, dass GALT nicht wie gewünscht pathogen war und zudem wider der Erwartung sogar eine protektive Wirkung bei der Induktion der EAE besitzt (Teitelbaum et al. 1971).

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Authors and Affiliations

  1. Rostock, Deutschland

    U. K. Zettl, U. Walter, A. Kloth, R. Benecke, E. Kunesch, A. Wolters, J. Classen, S. Weirich, S. Bischof, T. H. Broese, W. Lüdemann, M. Schicke, G. Schmid, K. Titz, D. Schläfke, S. Bohne, A. Grossmann, J. Buchmann, J. Höppner, J. Richter, W. Gierow, G. Irmisch, C. Göhre, D. Unger, U. Wartemann, F. Hässler, E. Respondek, B. Greim, S. Ruckert & U. K. Zettll

  2. Stralsund, Deutschland

    K. U. Kuehn, W. Schroeder, J. Armbruster, G. Abraham, A. Schattenberg, M. Gaensicke, S. Barnow, F. H. Herrmann, H. J. Freyberger, B. Mundt, K. Stutz, H. Tretzel, F. Michels-Lucht, C. Spitzer, M. Lucht, U. Siebel, H. J. Grabe, D. Alte & U. John

  3. Güstrow, Deutschland

    M. Roth, S. Gabriel, P. Vetter, D.-R. Meyer & R. Andresen

  4. Berlin, Deutschland

    W. Müller

  5. Würzburg, Deutschland

    R. Gold

  6. Ueckermünde, Deutschland

    A. Nguento, M. Schulz & T. Krüger

  7. Plau, Am, See, Deutschland

    K. Terstegge

  8. Essen, Deutschland

    H. Henkes

  9. Wismar, Deutschland

    A. Stiebler & M. Nichtweiss

  10. Neubrandenburg, Deutschland

    M. Müller, R. Jahns, B. Bauer, G. Zinapold, B. Veit & A. Bock

  11. Greifswald, Deutschland

    G. Kallwellis, U. Schminke, K. Rieck, B. Gaida-Hommernick, M. R. Gaab, G. Rabending, U. Runge, U. Hartmann, R. Herzer, A. Heinrich, M. Klampe, I. Ringel, B. Müller-Oerlinghausen, M. Dudeck, S. Vogelgesang, H. Röder, C. H. Kessler, A. Fister, V. Steinhagen, G. Kirsch, M. R. Gaab, A. V. Khaw & A. Bleiss

  12. Schwerin, Deutschland

    K. Konnopka, G. Schoefer-Timpe, K. Wegmann, P. Schütte, K.-R. Bogun & L. M. Drach

  13. Frankfurt A. Main, Deutschland

    S. Weidauer & S. Herminghaus

  14. Freiburg, Deutschland

    J. Spreer

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© 2001 Springer Fachmedien Wiesbaden

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Zettl, U.K. et al. (2001). Zusammenfassung der Vorträge. In: Bildgebende Verfahren in der Neurologie und Psychiatrie. Deutscher Universitätsverlag, Wiesbaden. https://doi.org/10.1007/978-3-663-09415-9_1

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  • DOI: https://doi.org/10.1007/978-3-663-09415-9_1

  • Publisher Name: Deutscher Universitätsverlag, Wiesbaden

  • Print ISBN: 978-3-8244-2149-7

  • Online ISBN: 978-3-663-09415-9

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