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Abstract

Diabetes mellitus represents one of the main risk factors of arteriosclerosis. Vascular complications are the most important cause of its mortality. Many questions relating the correlation between diabetes mellitus and arteriosclerosis are open: is the macroangiopathia diabetica a specific disease? Which factors are responsible for the development of vascular disease in diabetes mellitus, effects of glucose and insulin on the arterial wall, effects of circulating lipoproteins, abnormalities of blood clotting, elevated blood pressure? Even the influence of antidiabetic treatment itself has been suggested.

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References

  • Bar-On, H., Roheim, P. S., and Eder, H. A. (1976): Serum lipoproteins and apolipoproteins in rats with Streptozotocin-induced diabetes. J. Clin. Invest 57, 714 to 721.

    Article  PubMed  CAS  Google Scholar 

  • Benditt, E. P., and Benditt, J. M. (1973): Evidence for a monoclonal origin of human atherosclerotic plaques. Proc. nat. Acad. Sci. (Wash.) 70, 1753 to 1756.

    Article  CAS  Google Scholar 

  • Dénes, R., Kammerer, L., Virâg, S., Stützel, M., Steingaszner, O., and Lévai, J. (1973): Die Wirkung von oralen Antidiabetica und Insulin an normalen und alloxan-diabetischen Ratten auf die 125I-markierte Beta-Lipoprotein-Aufnahme der Aorta. In: “III. Internationales Donau-Symposium über Diabetes mellitus, Salzburg”, pp. 493 to 503. Wilhelm Maudrich, Wien.

    Google Scholar 

  • Dénes, R., Kerényi, T., Lehmann, R., Hauss, W. H., and Jellinek, H. (1978): Permeability changes of the aortic wall in short-term Streptozotocin diabetes. In: “Atherogenese III. Proceedings of the First International Atherosclerosis Conference”. Wilhelm Maudrich, Wien (in press).

    Google Scholar 

  • Dzoga, K., Wissler, R. W., and Vesselinovitch, D. (1971): The effect of normal and hyperlipemic low density lipoprotein fractions on aortic tissue culture cells. Circulation 44, Suppl. II, 6.

    Google Scholar 

  • Fischer-Dzoga, K., and Wissler, R. W. (1976): Stimulation of proliferation in stationary primary cultures of monkey aortic smooth muscle cells. Part 2. Effect of varying concentrations of hyperlipemic serum and low density lipoproteins of varying dietary fat origins. Atherosclerosis 24, 515 to 525.

    Article  PubMed  CAS  Google Scholar 

  • Geer, J. C., and Haust, M. D. (1972): Smooth muscle cells in atherosclerosis. Monographs on atherosclerosis. Vol. 2, pp. 1 to 140. S. Karger, Basel.

    Google Scholar 

  • Gerte, S., Bihari-Varga, M., and Virâg, S. (1973): Studies on the functional properties of vascular mucopolysaccharides. In: “Vascular and Neurological Changes in Early Diabetes” ( R. A. Camerini-Davalos, H. S. Cole, eds.), pp. 103 to 110. Academic Press, New York.

    Google Scholar 

  • Haimovici, H., and Maier, N. (1971): Experimental canine atherosclerosis in autogenous abdominal aortic grafts implanted into the jugular vein. Atherosclerosis 13, 375 to 384.

    Article  PubMed  CAS  Google Scholar 

  • Hauss, W. H. (1963): Pathogenese der Coronarsklerose und des Herzinfarktes. Verh. Dtsch. Ges. Inn. Med. LXIX, 554 to 573.

    Google Scholar 

  • Hauss, W. H. (1973): Über die Rolle des Mesenchyms in der Genese der Arteriosklerose. Virchows Arch. Abt. A Path. Anat. 359, 135 to 156.

    Article  CAS  Google Scholar 

  • Hauss, W. H. (1976a): The role of the mesenchymal cells in arteriosclerosis. Front. Matrix Biol. Vol. 2, pp. 89 to 124. S. Karger, Basel.

    Google Scholar 

  • Hauss, W. H. (1976b): Role of arterial wall cells in sclerogenesis. Ann. N.Y. Acad. Sci. 275, 286 to 301.

    Article  PubMed  CAS  Google Scholar 

  • Hauss, W. H., Junge-Hülsing, G., and Gerlach, U. (1968): Die unspezifische Mesenchymreaktion. pp. 1 to 155. Georg Thieme, Stuttgart.

    Google Scholar 

  • Hauss, W. H., Junge-Hülsing, G., Kuckulies, I., Otto, H., Rawytsch, J., and Wagner, H. (1968): Verlängerte biologische Halbwertszeit der sulfatierten Mucopolysaccharide bei Alloxandiabetes als Ursache der diabetischen Mesenchymstoffwechselstörung. Z. klin. Chem. Biochem. 6, 241 to 244.

    CAS  Google Scholar 

  • Hauss, W. H., Junge-Hülsing, G., Kuckulies, I., Otto, H., Rawytsch, I., and Wagner, H. (1969): Synthese und Umsatzrate sulfatierter Mucopolysaccharide bei alloxandiabetischen Ratten. Beitrag zur Pathogenese des diabetischen Mesenchymschadens. Diabetologica 5, 128 to 129.

    Google Scholar 

  • Ledet, T. (1976): Growth of rabbit aortic smooth muscle cells in serum from patients with juvenile diabetes. Acta path. microbiol. stand. Sect. A 84, 508 to 516.

    CAS  Google Scholar 

  • Ledet, T. (1978): A factor in diabetic serum stimulating proliferation of arterial medial cell culture. In “State of Prevention and Therapy in Human Arteriosclerosis and in Animal Models”. Abh. der Rhein.-Westf. Akademie der Wissenschaften, Bd. 63, Westdeutscher Verlag, Opladen, 333 to 342.

    Google Scholar 

  • Ledet, T., Fischer-Dzoga, K., and Wissler, R. W. (1977): Growth of rabbit aortic smooth muscle cells cultured in media containing diabetic and hyperlipemic serum. Diabetes 25, 207 to 215.

    Article  Google Scholar 

  • Lee, K. T., Thomas, W. A., Florentin, R. A., Reiner, J. M., and Lee, W. M. (1976): Evidence for a polyclonal origin and proliferative heterogeneity of atherosclerotic lesions induced by dietary cholesterol in young swine. Ann. N.Y. Acad. Sci. 275, 336 to 347.

    Article  PubMed  CAS  Google Scholar 

  • Lehmann, R., Dénes, R., Kerényi, T., and Hauss, W. H. (1978): Alteration of DNA template activity in artery wall cells induced by risk factors. In: “State of Prevention and Therapy in Human Arteriosclerosis and in Animal Models”. Abh. der Rhein.-Westf. Akademie der Wissenschaften, Bd. 63, Westdeutscher Verlag, Opladen, 267 to 283.

    Google Scholar 

  • Martin, G. M., Sprague, C. A., Norwood, T. H., and Pendergass, W. R. (1974): Clonal selection, attenuation and differentiation in an in vitro model of hyperplasia. Am. J. Pathol. 74, 137 to 154.

    PubMed  CAS  Google Scholar 

  • Ross, R. (1975): Smooth muscle cell and atherosclerosis. Verh. Dtsch. Ges. Inn. Med. LXXXI, 843 to 847.

    Google Scholar 

  • Ross, R., and Glomset, I. A. (1973): Atherosclerosis and the arterial smooth muscle cell. Science 180, 1332 to 1339.

    Article  PubMed  CAS  Google Scholar 

  • Schmitt, G., Knoche, H., Junge-Hülsing, G., Koch, R., and Hauss, W. H. (1970): Ober die Reduplication von Aortenwandzellen bei arterieller Hypertonie. Z. Kreislaufforsch. 59, 481 to 487.

    CAS  Google Scholar 

  • Stary, H. C. (1974): Proliferation of arterial cell in atherosclerosis. In: “Arterial Mesenchyme and Arteriosclerosis” (W. D. Wagner, T. B. Clarkson, eds.), pp. 59–81. Advances in Experimental Medicine and Biology. Vol. 43. Plenum Press, New York.

    Google Scholar 

  • Stout, R. W., Bierman, E. L., and Ross, R. (1975): Effect of insulin on the proliferation of cultured arterial smooth muscle cells. Circ. Res. 36, 319 to 327.

    Article  PubMed  CAS  Google Scholar 

  • Thomas, W. A., Florentin, R. A., Reiner, J. M., Lee, W. M., and Lee, K. I. (1976): Alterations in population dynamics of arterial smooth muscle cells during atherogenesis. IV. Evidence for a polyclonal origin of hypercholesterolemic diet-induced atherosclerotic lesions in young swine. Exp. mol. Path. 24, 244 to 260.

    Article  CAS  Google Scholar 

  • Virâg, S., Dénes, R., and Pozsonyi, T. (1970): Uptake of l25I-ß-lipoprotein by aortas and veins of normal and cholesterol-fed rabbits. Atherosclerosis 11, 361 to 363.

    Article  PubMed  Google Scholar 

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© 1978 Springer Fachmedien Wiesbaden

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Dénes, R., Mey, J., Lehmann, R., Hauss, W.H. (1978). Vascular Smooth Muscle Cells in Culture after Experimental Diabetes. In: International Symposium State of Prevention and Therapy in Human Arteriosclerosis and in Animal Models. Abhandlungen der Rheinisch-Westfälischen Akademie der Wissenschaften. VS Verlag für Sozialwissenschaften, Wiesbaden. https://doi.org/10.1007/978-3-663-06754-2_29

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  • DOI: https://doi.org/10.1007/978-3-663-06754-2_29

  • Publisher Name: VS Verlag für Sozialwissenschaften, Wiesbaden

  • Print ISBN: 978-3-531-05077-5

  • Online ISBN: 978-3-663-06754-2

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