Abstract
The Diabetes Intervention Study is a prospective controlled three-part-study with 1 139 newly detected NIDDM. The present report analyses the significance of hypertriglyceridaemia (HTG) as an independent risk factor for myocardial infarction in NIDDM. Furthermore we tested whether “good” TG-control according to the target levels of the NIDDM-Policy Group reduces the incidence of infarction. In multivariate analysis TG was shown to be an independent risk factor ranking second after blood pressure. The incidence of myocardial infarction in the subgroup with TG < 1.7 mM was 32 % and with TG > 2.3 mM 106 % (p > 0.01) — our data confirm HTG as an independent risk factor in NIDDM. Strict control of TG-level was associated with lower incidence of infarction.
Zusammenfassung
Die Diabetesinterventionsstudie (DIS) ist eine prospektive dreiarmige kontrollierte Studie mit 1139 repräsentativen neu diagnostizierten Typ-II-Diabetikern. In der vorliegenden Arbeit wurde analysiert, welchen Stellenwert die Hypertriglyzeridämie (HTG) als Risikofaktor für den Infarkt bei dieser Krankheitsgruppe hat und inwieweit durch optimale TG-Einstellung entsprechend den sogenannten ‚Euronormen‘ die Infarktinzidenzgesenktwerden kann. Bei multivariater Auswertung waren die TG nach der Hypertonie der wichtigste unabhängige Risikofaktor. Bei TG-Werten < 1,7 mmol/I betrug die Infarktinzidenz 32 %, bei TG-Konzentrationen > 2,3 mmol/I 106 % (p < 0,01). Die Ergebnisse zeigen, daß die HTG bei NIDDM (nichtinsulinabhängigen Diabetikern) ein unabhängiger Risikofaktor ist. Konsequente Korrektur der HTG reduziert das Infarktrisiko.
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Literaturverzeichnis
Fontbonne A, Eschwege E, Gambien F et al. Hypertriglyceridemia as a risk factor for coronary heart disease mortality in subjects with impaired glucose tolerance or diabetes. Results from 11-year follow-up of the Paris Prospective Study. Diabetologia 1989; 32: 300–304.
Hanefeld M, Haller H, Schulze J, Julius U, Fischer S, Rothe G. Die Diabetesinterventionsstudie (DIS), eine multizentrische Multiinterventionsstudie bei Typ-2-Diabetikern. Dtsch Gesundh Wes 1984; 30: 1889–1894.
Hanefeld M, Fischer S, Schmechel H et al. Diabetes intervention study: Multiintervention trial in newly diagnosed NIDDM. Diabetes Care 1991; 14: 308–317.
Hanefeld M, Schmechel H, Julius U et al. Five year incidence of coronary heart disease related to major risk factors and metabolic control in newly diagnosed non insulin dependent diabetes. The Diabetes Intervention Study (DIS). Nutr Metab Cardiovasc Dis 1991; 1: 135140.
Hanefeld M. Relationship between insulin and coronary heart disease. In: Standl E (ed.). Perspectives of the hyperinsulinemia/insulin resistance syndrome in NIDDM. MMV Medizin Verlag: München 1991; 70–73.
Janka H, Standl E. Hyperinsulinemia as possible risk factor of macrovascular disease in diabetes mellitus–an overview. Diabete Metab 1978; 13: 279–283.
Reaven GM, Greenfeld MS. Diabetes hypertriglyceridemia. Evidence for three clinical syndroms. Diabetes 1981; 30 (Suppl 2): 66–75.
Santen RJ, Willis P, Fajans S. Atherosclerosis in diabetes mellitus. Correlations with serum lipid levels, adiposity and serum insulin level. Arch Intern Med 1972; 130: 833–43.
West K, Ahuja M, Bennet P. The Role of circulating glucose and triglyceride concentrations and their interaction with other risk factors as determinants of arterial disease in nine diabetic population samples from the WHO. Multinational Study. Diabetes Care 1963; 6: 361–369.
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© 1993 Springer Fachmedien Wiesbaden
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Hanefeld, M. et al. (1993). Hypertriglyceridaemia (HTG) as independent risk factor for myocardial infarction in type 2 diabetes: The Diabetes Intervention Study. In: Heinle, H., Schulte, H., Schaefer, H.E. (eds) Diätetik und Arteriosklerose. Vieweg+Teubner Verlag, Wiesbaden. https://doi.org/10.1007/978-3-663-01942-8_18
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DOI: https://doi.org/10.1007/978-3-663-01942-8_18
Publisher Name: Vieweg+Teubner Verlag, Wiesbaden
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