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Treatment of Chronic Salmonella Carriers with Ciprofloxacin

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Ciprofloxacin

Part of the book series: Current Topics in Infectious Diseases and Clinical Microbiology ((CTIDCM,volume 1))

Abstract

As chronic salmonella carriers represent a hazard to the community it is in the public interest to terminate excretion of the organisms. Antimicrobial agents used for this purpose include ampicillin, cotrimoxazole and rifampicin, the success rates being about 60% (1, 2, 3). Ciprofloxacin, an oxiquinolone derivative, shows rapid bactericidal action, is highly active against salmonella and does not influence the anaerobic faecal flora. Ciprofloxacin concentrations achieved in bile are approximately tenfold those in serum (4). These favourable bacteriological and pharmacokinetic characteristics formed the rationale for a study using ciprofloxacin to treat chronic salmonella carriers.

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References

  1. Freerksen, E., Rosenfeld, M., Freerksen, R.: Treatment of chronic salmonella carriers. Chemotherapy 1977, 23: 192–210.

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  2. Pichler, H., Spitzy, K. H., Knothe, H.: Zur Sanierung von Salmonellen-Dauerausscheidern mit Trimethoprim-Sulfonamid. Zentralbatt für Bakteriologie und Hygiene 1976, 252: 129–132.

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  3. Dinbar, A., Altmann, G., Tulcinsky, D. B.: The treatment of chronic biliary salmonella carriers. American Journal of Medicine 1969, 47: 236–242.

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  4. Shah, P. M.: Enterohepatischer Kreislauf von Ciprofloxacin. Zeitschrift für antimikrobielle und antineoplastische Chemotherapie 1985, 3: 85–86.

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Author information

Authors and Affiliations

  1. Department of Infectious Diseases, Kaiser Franz Josef-Hospital, Kundratstraße 3, 1100, Vienna, Austria

    G. Diridl & H. Pichler

  2. Institute of Bacteriology, Kaiser Franz Josef-Hospital, Kundratstraße 3, 1100, Vienna, Austria

    D. Wolf

Authors
  1. G. Diridl
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  2. H. Pichler
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  3. D. Wolf
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Editor information

H. C. Neu D. S. Reeves

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© 1986 Springer Fachmedien Wiesbaden

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Diridl, G., Pichler, H., Wolf, D. (1986). Treatment of Chronic Salmonella Carriers with Ciprofloxacin. In: Neu, H.C., Reeves, D.S. (eds) Ciprofloxacin. Current Topics in Infectious Diseases and Clinical Microbiology, vol 1. Vieweg+Teubner Verlag, Wiesbaden. https://doi.org/10.1007/978-3-663-01930-5_40

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  • DOI: https://doi.org/10.1007/978-3-663-01930-5_40

  • Publisher Name: Vieweg+Teubner Verlag, Wiesbaden

  • Print ISBN: 978-3-663-01931-2

  • Online ISBN: 978-3-663-01930-5

  • eBook Packages: Springer Book Archive

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