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Ciprofloxacin pp 55–58Cite as

Single and Multiple Dose Pharmacokinetics of Ciprofloxacin

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Part of the book series: Current Topics in Infectious Diseases and Clinical Microbiology ((CTIDCM,volume 1))

Abstract

Penetration of ciprofloxacin into nasal secretion was studied in 20 healthy volunteers towhom 500 mg oral ciprofloxacin was administered twice daily for eight days. Nasal secretion and blood samples were collected following the 1st and 15th dose and samples assayed microbiologically. Absolute concentrations of ciprofloxacin in serum and nasal secretion as well as kinetic parameters indicate that repeated administration did not result in significantly increased serum or nasal secretions levels although there was a tendency towards slight drug accumulation. The rate of penetration of ciprofloxacin into nasal secretion was 73% following the first oral dose and 90% following the 15th oral dose.

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Authors and Affiliations

  1. Department of Medical Microbiology, University of Kiel, Brunswiker Str. 2-6, 2300, Kiel 1, Germany

    U. Ullmann

  2. Biochemical Laboratory, ENT-Clinic, University of Tübingen, Silcher Str. 5, 7400, Tübingen 1, Germany

    W. Giebel

  3. Pharma Research Center, Bayer AG, PO Box 10 17 09, 5600, Wuppertal 1, Germany

    A. Dalhoff

  4. Medical Department, Klinikum Steglitz, Free University of Berlin, Hindenburgdamm 30, 1000, Berlin 45, Germany

    P. Koeppe

Authors
  1. U. Ullmann
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  2. W. Giebel
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  3. A. Dalhoff
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  4. P. Koeppe
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Editor information

H. C. Neu D. S. Reeves

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© 1986 Springer Fachmedien Wiesbaden

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Ullmann, U., Giebel, W., Dalhoff, A., Koeppe, P. (1986). Single and Multiple Dose Pharmacokinetics of Ciprofloxacin. In: Neu, H.C., Reeves, D.S. (eds) Ciprofloxacin. Current Topics in Infectious Diseases and Clinical Microbiology, vol 1. Vieweg+Teubner Verlag, Wiesbaden. https://doi.org/10.1007/978-3-663-01930-5_17

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  • DOI: https://doi.org/10.1007/978-3-663-01930-5_17

  • Publisher Name: Vieweg+Teubner Verlag, Wiesbaden

  • Print ISBN: 978-3-663-01931-2

  • Online ISBN: 978-3-663-01930-5

  • eBook Packages: Springer Book Archive

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