Abstract
Ciprofloxacin (Bay o 9867), a new antibacterial agent structurally related to nalidixic acid, has a broad antimicrobial spectrum against both gram-positive and gram-negative bacteria (1). We evaluated its in vitro activity against Brucella spp. in comparison to that of three other quinoline derivatives and gyrase inhibitors, norfloxacin, pipemidic acid and nalidixic acid (2–3), using 68 clinical isolates of Brucella melitensis. Susceptibility tests were performed by the agar dilution technique using chocolate agar plates inoculated with the organism and incubated for 48 h at 37°C in an atmosphere enriched with CO2.
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References
Bauernfeind, A., Petermüller, C.: In vitro activity of ciprofloxacin, norfloxacin and nalidixic acid. European Journal of Clinical Microbiology 1983, 2: 111–115.
Ito, A., Hirai, K., Inove, M., Koga, H., Suzue, S., Irikura, T., Mitsuhashi, S.: In vitro antibacterial activity of AM-715, a new nalidixic acid analog. Antimicrobial Agents and Chemotherapy 1980, 17: 103–108.
King, A., Warren, C., Shannon, K., Phillips, I.: In vitro antibacterial activity of norfloxacin (MK-0366). Antimicrobial Agents and Chemotherapy 1982, 21: 604–607.
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© 1986 Springer Fachmedien Wiesbaden
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Gobernado, M., Cantón, E., Santos, M. (1986). In Vitro Activity of Ciprofloxacin Against Brucella melitensis . In: Neu, H.C., Reeves, D.S. (eds) Ciprofloxacin. Current Topics in Infectious Diseases and Clinical Microbiology, vol 1. Vieweg+Teubner Verlag, Wiesbaden. https://doi.org/10.1007/978-3-663-01930-5_10
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DOI: https://doi.org/10.1007/978-3-663-01930-5_10
Publisher Name: Vieweg+Teubner Verlag, Wiesbaden
Print ISBN: 978-3-663-01931-2
Online ISBN: 978-3-663-01930-5
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