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Zusammenfassung

Die Evolution vom einzelligen Lebewesen zu vielzelligen Organismen mit funktionsspezifischen Organen schließt auch die Entwicklung eines Immunsystems ein. Es dient der Erhaltung der individuellen Integrität, indem es Veränderungen von Selbst zu Nichtselbst auf molekularer Ebene wahrnimmt, diese mit verschiedenen Effektormechanismen attackiert und zu eliminieren trachtet. Der Immunapparat ist kein kompaktes Organ, sondern ein disloziertes System, darin dem blutbildenden System vergleichbar und diesem auch räumlich eng verbunden. Es wirkt mit seinen Effektormechanismen in praktisch alle Gewebe des Organismus hinein, darunter auch in die Haut.

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Literatur

  1. Aberer, W., G. Schuler, G. Stingl, H. Hönigsmann, K. Wolff: Ultraviolet light depletes surface markers of Langerhans cells. J. Invest. Dermatol. 76 (1981) 202–210.

    Article  Google Scholar 

  2. Arend, W. P., H. G. Welgus, R. C. Thompson, S. P. Eisenberg: Biological properties of recombinant human monocyte-derived interleukin-1 receptor antagonist. J. Clin. Invest. 85 (1990) 1694–1697.

    Article  Google Scholar 

  3. Asherson, G. L., G. G. Allwood, B. Mayhew: Movement of T blasts in the draining lymph nodes to sites of inflammation. Immunology 25 (1973) 485–494.

    Google Scholar 

  4. Bach, F.H., D.H. Sachs: Current concepts: Immunology. Transplantation immunology. N. Engl. J.Med. 317 (1987) 489–492.

    Article  Google Scholar 

  5. Bergstresser, P.R., R.E. Tigelaar, J.H. Dees, J. W. Streilein: Thy-1 antigen-bearing dendritic cells populate murine epidermis. J. Invest. Dermatol. 81 (1983) 286–288.

    Article  Google Scholar 

  6. Beutler, B., A. Cerami: Cachectin: more than a tumor necrosis factor. N. Eng. J. Med. 316 (1987) 379–385.

    Article  Google Scholar 

  7. Braathen, L. R., E. Thorsby: Studies on human Langerhans cells. I. Alloactivating and antigen presenting capacity. Scand. J. Immunol. 11 (1980) 401–408.

    Article  Google Scholar 

  8. Carswell, E.A., L.J. Old, R.L. Kassel, S. Green, N. Fiore, B. Williamson: An endotoxin-induced serum factor that causes necrosis of tumors. Proc. Natl. Acad. Sci. USA 72 (1975) 3666–3670.

    Article  Google Scholar 

  9. Clark, S. C, R. Kamen: The human hematopoietic colony stimulating factors. Science 236 (1987) 1229–1232.

    Article  Google Scholar 

  10. Collins, T., L. A. Lapierre, W. Fiers, J. L. Strominger, J. S. Pober: Recombinant human tumor necrosis factor increases mRNA levels and surface expression of HLA-A, B antigens in vascular endothelial cells and dermal fibroblasts in vitro. Proc. Natl. Acad. Sci. USA 83 (1986) 446–450.

    Article  Google Scholar 

  11. Danner, M., T. A. Luger: Human keratinocytes and epidermoid carcinoma cell lines produce a cytokine with interleukin 3-like activities. J. Invest. Dermatol. 88 (1987) 353–361.

    Article  Google Scholar 

  12. Dinarello, C. A., J. G. Cannon, S. M. Wolff, H.A. Bernheim, B. Beutler, A. Cerami, I. S. Figari, M. A. Palladino Jr.: Tumor necrosis factor (cachectin) is an endogenous pyrogen and induces production of interleukin 1. J. Exp. Med. 163 (1986) 1433–1450.

    Article  Google Scholar 

  13. Durum, S. K., K. Mealy: Hilton Head revisited — cytokine explosion of the 80s takes shape for the 90s. Immunol. Today 11 (1990) 103–106.

    Article  Google Scholar 

  14. Durum, S. K., J. A. Schmidt, J. J. Oppenheim: Interleukin 1: an immunological perspective. Ann. Rev. Immunol. 3 (1985) 263–287.

    Article  Google Scholar 

  15. Edelson, R. L.: Cutaneous T cell lymphoma: Mycosis fungoides, Sézary syndrome, and other variants. J. Amer. Acad. Dermatol. 2 (1980) 89–106.

    Article  Google Scholar 

  16. Eisenberg, S.P., R.J. Evans, W.P. Arend, E. Verderber, M.T. Brewer, C.H. Hannum, R.C. Thompson: Primary structure and functional expression from complementary DNA of a human interleukin-1 receptor antagonist. Nature 343 (1990) 341–346.

    Article  Google Scholar 

  17. Fincham, N.J., R. D. R. Camp, A. J. H. Gearing, C. R. Bird, F. M. Cunningham: Neutrophil chemoattractant and IL-1-like activity in samples from psoriatic skin lesions. J. Immunol. 140 (1988) 4294–4299.

    Google Scholar 

  18. Gahring, L. C, A. Buckley, R. A. Daynes: The presence of ETAF/IL-1 in normal human stratum corneum. J. Clin. Invest. 76 (1985) 1585–1591.

    Article  Google Scholar 

  19. Gauldie, J., C. Richards, D. Harnish, P. Landsdorp, H. Baumann: Interferon β2/B-cell stimulating factor type 2 shares identity with monocyte derived hepatocyte-stimulating factor and regulates the major acute phase protein response in liver cells. Proc. Natl. Acad. Sci. USA 84 (1987) 7251–7256.

    Article  Google Scholar 

  20. Griscelli, C, P. Vasalli, R. T. McCluskey: The distribution of large dividing lymph node cells in syngeneic recipients after intravenous injection. J. Exp. Med. 130 (1969) 1427–1451.

    Article  Google Scholar 

  21. Halstead, T.E., J.G. Hall: The homing of lymph-borne immunoblasts to the small gut of neonatal rats. Transplantation 14 (1972) 339–346.

    Article  Google Scholar 

  22. Hannum, C. H., C.J. Wilcox, W. P. Arend, F. G. Joslin, D.J. Dripps, P. L. Heimdal, L. G. Armes, A. Sommer, S. P. Eisenberg, R. C. Thompson: Interleukin-1 receptor antagonist activity of a human interleukin-1 inhibitor. Nature 343 (1990) 336–340.

    Article  Google Scholar 

  23. Helfgott, D.C., S.B. Tatter, U. Santhanam, R.H. Clarick, N. Bhardwaj, L.T. May, P.B. Sehgal: Multiple forms of IFN-ß2/IL-6 in serum and body fluids during acute bacterial infection. J. Immunol. 142 (1989) 948–953.

    Google Scholar 

  24. Heufler, C, F. Koch, G. Schuler: Granulocyte-macrophage colony-stimulating factor and Interleukin-1 mediate the maturation of murine epidermal Langerhans cells into potent immune stimulatory dendritic cells. J. Exp. Med. 167 (1988) 1–7.

    Article  Google Scholar 

  25. Hoefsmit, E. C. M., A. M. Duivestijn, E. W. A. Kamperdijk: Relation between Langerhans cells, veiled cells and interdigitating cells. Immunobiol. 161 (1982) 252–265.

    Article  Google Scholar 

  26. Hopkins, J., J. G. Hall: Selective entry of immunoblasts into gut from intestinal lymph. Nature 259 (1976) 308–309.

    Article  Google Scholar 

  27. Horowitz, M. C., R. Langdon, L. Lightfoot, U. Gubler: Human keratinocytes contain mRNA indistinguishable from monocyte interleukin 1 and RNA. Keratinocyte epidermal cell derived thymocyte activating factor is identical to interleukin 1. J. Exp. Med. 164 (1986) 2095–2100.

    Article  Google Scholar 

  28. Inaba, K., G. Schüler, M. D. Witmer, J. Valinsky, B. Atassi, R. M. Steinman: Immunologic properties of purified epidermal Langerhans cells. Distinct requirements for stimulation of unprimed and sensitized T lymphocytes. J. Exp. Med. 164 (1986) 605–613.

    Article  Google Scholar 

  29. Inaba, K., R. M. Steinman: Resting and sensitized T lymphocytes exhibit distinct stimulatory (antigen-presenting cell) requirements for growth and lymphokine release. T. Exp. Med. 160 (1984) 1717–1735.

    Article  Google Scholar 

  30. Inaba, K., R. M. Steinman: Accessory cell — T lymphocyte interactions. Antigen-dependent and-independent clustering. J. Exp. Med. 163 (1986) 247–261.

    Article  Google Scholar 

  31. Janossy, G., N. Tidman, W. S. Selby, J. A. Thomas, S. Granger: Human T lymphocytes of inducer and suppressor type occupy different microenvironments. Nature 288 (1980) 81–84.

    Article  Google Scholar 

  32. Kaplan, G., A. D. Luster, G. Hancock, Z. A. Cohn: The expression of a γ-interferon-induced protein (IP-10) in delayed immune responses in human skin. J. Exp. Med. 166 (1987) 1098–1108.

    Article  Google Scholar 

  33. Kehrl, J. H., A. Miller, A. S. Fauci: Effect of tumor necrosis factor on mitogen-activated human B cells. J. Exp. Med. 166 (1987) 786–792.

    Article  Google Scholar 

  34. Kehrl, J. H., L. M. Wakefield, A. B. Roberts, S. Jakowlew, M. Alvarez-mon, R. Derynick, M. B. Sporn, A. S. Fauci: Production of transforming growth factor β by human T-lymphocytes, and its potential role in the regulation of T cell growth. J. Exp. Med. 163 (1986) 1037–1048.

    Article  Google Scholar 

  35. Kirnbauer, R., A. Köck, J. Krutmann, T. Schwarz, A. Urbanski, T. A. Luger: Different effects of UVA and UVB irradiation on epidermal cell IL-6 expression and release. J. Invest. Dermatol. 92 (1989) 459 abstr.

    Google Scholar 

  36. Kirnbauer, R., A. Köck, T. Schwarz, A. Urbanski, J. Krutmann, W. Borth, D. Damm, G. Shipley, J. C. Ansel, T. A. Luger: IFN-ß2, B cell differentiation factor 2, or hybridoma growth factor (IL-6) is expressed and released by human epidermal cells and epidermoid carcinoma cell lines. J. Immunol. 142 (1989) 1922–1928.

    Google Scholar 

  37. Knop, J., E. Macher. Das allergische Kontaktekzem. In: Fuchs, E., K.-H. Schulz (Hrsg.): Manuale allergologicum. Dustri, Deisenhofen, Bd. II, Kap. V. 16:1-16:17.

    Google Scholar 

  38. Köck, A., A. Urbanski, T. A. Luger: mRNA expression and release of tumor necrosis factor a by human epidermal cells. J. Invest. Dermatol. 92 (189) 462 abstr.

    Google Scholar 

  39. Koch, F., C. Heufler, D. Schneeweiss, E. Kaempgen, G. Schüler: Tumor necrosis factor alpha maintains the viability of murine epidermal Langerhans cells in culture but in contrast to GM-CSF without inducing functional maturation. J. Invest. Dermatol. 92 (1989) 461 abstr.

    Google Scholar 

  40. Kownatzki, E., A. Kapp, S. Uhrich: Novel neutrophil chemotactic factor derived from human peripheral blood mononuclear leukocytes. Clin. Exp. Immunol. 64 (1986) 214–222.

    Google Scholar 

  41. Krutmann, J., R. Kirnbauer, A. Köck, T. Schwarz, E. Schöpf, L.T. May, P.B. Sehgal, T.A. Luger: Cross-linking Fc receptors on monocytes triggers IL-6 production. Role in Anti-CD3-induced T cell activation. J. Immunol. 145 (1990) 1337–1342.

    Google Scholar 

  42. Küpper, T. S., D. L. Coleman, J. McGuire, D. Goldminz, M. C. Horowitz: Keratinocyte-derived T cell growth factor. A T cell growth factor functionally distinct from interleukin 2. Proc. Natl. Acad. Sci. USA 83 (1986) 4451–4455.

    Article  Google Scholar 

  43. Küpper, T. S., M. C. Horowitz, F. Lee, D. Coleman, P. Flood: Molecular characterization of keratinocyte cytokines. J. Invest. Dermatol. 88 (1987) 501A.

    Google Scholar 

  44. Küpper, T. S., L. May, N. Birchall, P. Sehgal: Keratinocytes produce interleukin 6, a cytokine which can provide a 2nd signal in the activation of T-cells. J. Invest. Dermatol. 90 (1988) 578 (abstr.).

    Google Scholar 

  45. Langerhans, P: Über die Nerven der menschlichen Haut. Virchows Arch. Path. Anat. Physiol. 44 (1868) 325–337.

    Google Scholar 

  46. Larsen, C. G., A. O. Anderson, E. Appella, J. J. Oppenheim, K. Matsushima: The neutrophil-activating protein (NAP-1) is also chemotactic for T-lymphocytes. Science 243 (1989) 1464–1466.

    Article  Google Scholar 

  47. Liden, S.: The mononuclear-cell infiltrate in allergic contact dermatitis. 3. Selective accumulation of cells from lymph nodes. Acta Pathol. Microbiol. Scand. 70 (1967) 363–370.

    Article  Google Scholar 

  48. Lotz, M., F. Jirik, P. Kabouridis, C. Tsoukas, T. Hirano, T. Kishimoto, D. A. Carson: B cell stimulating factor 2/interleukin 6 is a costimulant for human thymocytes and T-lymphocytes. J. Exp. Med. 167 (1988) 1253–1258.

    Article  Google Scholar 

  49. Luger, T. A., A. Köck, R. Kirnbauer, T. Schwarz, J. C. Ansel: Keratinocyte interleukin 3 production. Ann. NY. Acad. Sci. 548 (1989) 253–261.

    Article  Google Scholar 

  50. Luger, T.A., J. Krutmann, R. Kirnbauer, A. Urbanski, T. Schwarz, G. Klappacher, M. Miksche, J. Malejczyk, E. Schauer, L. T. May, P. B. Sehgal: Interferon β2/interleukin-6 augments the activity of human natural killer cells. J. Immunol. 143 (1989) 1206–1209.

    Google Scholar 

  51. Luger, T. A., B. M. Stadler, S. I. Katz, J. J. Oppenheim: Epidermal cell (keratinocyte)-derived thymocyte activating factor (ETAF). J. Immunol. 127 (1981) 1493–1498.

    Google Scholar 

  52. Luger, T.A., B.M. Stadler, B.M. Luger, B.J. Mathieson, M. Mage, J.A. Schmidt, J.J. Oppenheim: Murine epidermal cell derived thymocyte activating factor resembles murine interleukin 1. J. Immonol. 128 (1982) 2147–2152.

    Google Scholar 

  53. Luger, T. A., U. Wirth, A. Köck: Epidermal cells synthesize a cytokine with Interleukin-3 properties. J. Immunol. 134 (1985) 915–920.

    Google Scholar 

  54. Macher, E.: Die Reaktion der regionären Lymphknoten beim tierexperimentellen allergischen Kontaktekzem. I. Mitteilung: Makroskopische Untersuchungen. Hautarzt 13 (1962) 18–23.

    Google Scholar 

  55. Macher, E.: Die Reaktion der regionaären Lymphknoten beim tierexperimentellen allergischen Kontaktekzem. II. Mitteilung: Histologische Untersuchungen. Hautarzt 13 (1962) 128–131.

    Google Scholar 

  56. Macher, E.: Die Reaktion der regionären Lymphknoten beim tierexperimentellen allergischen Kontaktekzem. III. Mitteilung: Cytologische Untersuchungen. Hautarzt 13 (1962) 174–179.

    Google Scholar 

  57. Macher, E.: White blood cell counts in guinea pigs during sensitization to 2,4 dinitrochlorobenzene. Acta derm.-venereol. 48 (1968) 325–328.

    Google Scholar 

  58. Macher, E., I. Atzpodien: Doppelsensibilisierung von Meerschweinchen mit Dinitrochlorbenzol und Paraphenylendiamin und getrennte passive Übertragung der Allergien. Arch. klin. exp. Dermatol. 232 (1968) 195–204.

    Google Scholar 

  59. Macher, E., M.W. Chase: Studies on the sensitization of animals with simple chemical compounds. XI. The fate of labeled picryl chloride and dinitrochlorobenzene after sensitizing injection. J. Exp. Med. 129 (1969) 81–102.

    Article  Google Scholar 

  60. Macher, E., M. W. Chase: Studies on the sensitization of animals with simple chemical compounds. XII. The influence of excision of allergenic depots on onset of delayed hypersensitivity and tolerance. J. Exp. Med. 129 (1969) 103–121.

    Article  Google Scholar 

  61. Matsushima, K., K. Moroshita, T. Yoshimura, S. Lavu, Y. Kobayashi, W. Lew, E. Appella, H. F. Kung, E. J. Leonard, J. J. Oppenheim: Molecular clonig of a human monocyte-derived neutrophil chemotactic factor (MDNCF) and the induction of MDNCF mRNA by interleukin 1 and tumor necrosis factor. J. Exp. Med. 167 (1988) 1883–1892.

    Article  Google Scholar 

  62. McWilliams, M., J.M. Philips-Quagliata, M.E. Lamm: Characteristics of mesenteric lymph node cells homing to gut associated lymphoid tissue in syngeneic mice. J. Immunol. 115 (1975) 54–58.

    Google Scholar 

  63. Moore, A. R., J. G. Hall: Evidence for a primary association between immunoblasts and small gut. Nature 239 (1972) 161–162.

    Article  Google Scholar 

  64. Munker, R., J. Gasson, M. Ogawa, H.P. Koeffler: Recombinant human TNF induces production of granulocyte-monocyte colony-stimulating factor. Nature 323 (1986) 79–82.

    Article  Google Scholar 

  65. Neuner, P., A. Kapp, R. Kirnbauer, T. Schwarz, J. Krutmann, T. A. Luger: Monocytes derived from patients with psoriasis synthesize and release increased levels of interleukin 6. J. Invest. Dermatol. 92 (1989) 490 abstr.

    Google Scholar 

  66. Nickoloff, B. J., R. S. Mitra: Transforming growth factor-beta is a keratinocyte-derived lymphocyte inhibitory factor. J. Invest. Dermatol. 90 (1988) 592–607.

    Google Scholar 

  67. Nijsten, M. W. N., E. R. De Groot, H. J. Ten Duis, H. J. Klasen, C. E. Hack, L. A. Aarden: Serum levels of interleukin-6 and acute phase response. Lancet II (1987) 921.

    Article  Google Scholar 

  68. Nixon-Fulton, J. L., P. R. Bergstresser, J. Hackett Jr., V. Kumar, R. E. Tigelaar: Con-A stimulated Thy-1+ epidermal cells exhibit natural killer (NK)-like activity. Fed. Proc. Am. Soc. Exp. Biol. 44 (1985) 595 abstr.

    Google Scholar 

  69. Nophar, Y., O. Kemper, C. Brakebusch, H. Englemann, R. Zwang, D. Aderka, H. Holtmann, D. Wallach: Soluble forms of tumor necrosis factor receptors (TNF-Rs). The cDNA for the type ITNF-R, cloned using amino acid sequence data for its soluble form, encodes both the cell surface and a soluble form of the receptor. EMBO J. 9 (1990) 3269–3278.

    Google Scholar 

  70. Oxholm, A., P. Oxholm, B. Staberg, K. Bentzen: Immunohistological detection of interleukin 1-like molecules and tumour necrosis factor in human epidermis before and after UV-irradiation in vivo. Br. J. Dermatol. 118 (1988) 369–376.

    Article  Google Scholar 

  71. Pennica, D., M. R. Shalaby, M. A. Palladino Jr.: Tumor necrosis factors alpha and beta. In: Gillis, S. (ed.): Recombinant Lymphokines and their Receptors. M. Dekker, New York 1987, 35 (pp. 301–318).

    Google Scholar 

  72. Philipp, R., L.B. Epstein: Tumor necrosis factor as immunomodulator and mediator of monocyte cytotoxicity induced by itself, gamma-interferon and interleukin-1. Nature 323 (1986) 86–90.

    Article  Google Scholar 

  73. Poupart, P., P. Vandenabeele, S. Cayphas, J. V. Snick, G. Haegman, V. Kruys, W. Fiers, J. Content: B cell growth modulating and differentiating activity of recombinant human 26kD-protein (BSF-2, HuIFN-β2, HPGF). EMBO J. 6 (1987) 1219–1224.

    Google Scholar 

  74. Ranges, G. E., A. Zlotnik, T. Especik, C. A. Dinarello, A. Cerami, M. A. Palladino Jr.: Tumor necrosis factor α/cachectin is a growth factor for thymocytes. J. Exp. Med. 167 (1988) 1472–1479.

    Article  Google Scholar 

  75. Ristow, H.-J.: A major factor contributing to epidermal proliferation in inflammatory skin diseases appears to be interleukin 1 or a related protein. Proc. Natl. Acad. Sci. USA 84 (1987) 1940–1944.

    Article  Google Scholar 

  76. Romani, N., S. Koide, M. Crowley, M. Witmer-Pack, A.M. Livingstone, C.G. Fathman, K. Inaba, R. M. Steinman: Presentation of exogenous protein antigens by dendritic cells to T cell clones: intact protein is presented best by immature epidermal Langerhans cells. J. Exp. Med. 169 (1989) 1169–1178.

    Article  Google Scholar 

  77. Rose, M. L., D. M. V. Parrott, R. G. Bruce: Migration of lymphoblasts to the small intestine. II. Divergent migration of mesenteric and peripheral immunoblasts to sites of inflammation in the mouse. Cell. Immunol. 27 (1976) 36–46.

    Article  Google Scholar 

  78. Rothe, M., V. Falanga: Growth factors. Arch. Dermatol. 125 (1989) 1390–1398.

    Article  Google Scholar 

  79. Sauder, D. N., K. Tamaki, A. N. Moshell, H. Fujiwara, S. I. Katz: Induction of tolerance to topically applied TNCB using TNP-conjugated ultraviolet light-irradiated epidermal cells. J. Immunol. 127 (1981) 261–265.

    Google Scholar 

  80. Schrader, J. W: The panspecific hemopoietin of activated T lymphocytes (Interleukin-3). Ann. Rev. Immunol. 4 (1986) 205–230.

    Article  Google Scholar 

  81. Schröder, J. M., E. Christophers: Identification of a novel family of highly potent neutrophil chemotactic peptides in psoriatic scales. J. Invest. Dermatol. 91 (1988) 395 abstr.

    Google Scholar 

  82. Schuler, G., R.M. Steinman: Murine epidermal Langerhans cells mature into potent immunostimulatory dendritic cells in vitro. J. Exp. Med. 161 (1985) 526–546.

    Article  Google Scholar 

  83. Schwarz, T., A. Urbanska, F. Gschnait, T. A. Luger: UV-irradiated epidermal cells produce a specific inhibitor of interleukin-1 activity. J. Immonol. 138 (1987) 1457–1463.

    Google Scholar 

  84. Schwarz, T., A. Urbanski, R. Kirnbauer, A. Köck, F. Gschnait, T. A. Luger: Detection of a specific inhibitor of interleukin 1 in sera of UVB-treated mice. J. Invest. Dermatol. 91 (1988) 536–540.

    Article  Google Scholar 

  85. Sehgal, P. B., A. Zilberstein, R. M. Ruggieri, L. T. May, A. Fergusson-Smith, D. L. Slate, M. Revel, F.H. Ruddle: Human chromosome 7 carries the β2 interferone gene. Proc. Natl. Acad. Sci. USA 83 (1986) 5219–5222.

    Article  Google Scholar 

  86. Shevach, E. M.: Macrophages and other accessory cells. In: Paul, W. E. (ed.): Fundamental Immunology. Raven, New York 1984 (pp. 71–107).

    Google Scholar 

  87. Spies, T., C. C. Morton, S. A. Nedospasov, W. Fiers, D. Pious, J. L. Strominger: Genes for the tumor necrosis factor a and ß are linked to the human major histocompatibility complex. Proc. Natl. Acad. Sci. USA 83 (1986) 8699–8702.

    Article  Google Scholar 

  88. Steinman, R. M., Z. A. Cohn: Identification of a novel cell type in peripheral lymphoid organs of mice. I. Morphology, quantitation and tissue distribution. J. Exp. Med. 137 (1973) 1142–1162.

    Article  Google Scholar 

  89. Steinman, R.M., Z. A. Cohn: Identification of a novel cell type in peripheral lymphoid organs of mice. II. Functional properties in vitro. J. Exp. Med. 139 (1974) 380–397.

    Article  Google Scholar 

  90. Steinman, R. M., D. S. Lustig, Z. A. Cohn: Identification of a novel cell type in peripheral lymphoid organs of mice. III. Functional properties in vivo. J. Exp. Med. 139 (1974) 1431–1445.

    Article  Google Scholar 

  91. Stingl, G., L. Gazze-Stingl, W. Aberer, K. Wolff: Antigen presentation by murine epidermal Langerhans cells and its alteration by ultraviolet B light. J. Immunol. 127 (1981) 1707–1713.

    Google Scholar 

  92. Stingl, G., K.C. Gunter, E. Tschachler, H. Yamada, R.I. Lechler, W.M. Yokoyama, G. Steiner, R.N. Germain, E.M. Shevach: Thy-1+ dendritic epidermal cells belong to the T cell lineage. Proc. Natl. Acad. Sci. USA 84 (1987) 2430–2434.

    Article  Google Scholar 

  93. Stingl, G., S.I. Katz, L. Clement, I. Green, E.M. Shevach: Immunological functions of Ia-bearing epidermal Langerhans cells. J. Immunol. 121 (1978) 2005–2013.

    Google Scholar 

  94. Streilein J. W.: Skin-associated lymphoid tissues (SALT): origins and functions. J. Invest. Dermatol. (Suppl.) 80 (1983) 12s–16s.

    Article  Google Scholar 

  95. Sullivan, S., P. R. Bergstresser, R. E. Tigelaar, J. W. Streilein: Induction and regulation of contact hypersensitivity by resident, bone-marrow-derived, dendritic epidermal cells: Langerhans cells and Thy-1+ epidermal cells. J. Immunol. 137 (1986) 2460–2467.

    Google Scholar 

  96. Toews, G. B., P. R. Bergstresser, J. W. Streilein: Epidermal Langerhans density determines whether contact sensitivity or unresponsiveness follows skin painting with DNFB. J. Immunol. 124 (1980) 445–453.

    Google Scholar 

  97. Tschachler, E., G. Schüler, J. Hutterer, H. Leibl, K. Wolff, G. Stingl: Expression of Thy-1 antigen by murine epidermal cells. J. Invest. Dermatol. 81 (1983) 282–285.

    Article  Google Scholar 

  98. Van Damme, J., J. van Beeumen, G. Opdenakker, A. Billiau: A novel, NH2-terminal sequence-characterized human monokine possessing neutrophil chemotactic, skin-reactive, and granulocytosis-promoting activity. J. Exp. Med. 167 (1988) 1364–1376.

    Article  Google Scholar 

  99. Wahl, S. M., D. A. Hunt, H. L. Wong, S. Dougherty, N. McCartney-Francis, L. M. Wahl, L. Ellingsworth, J. A. Schmidt, G. Hall, A. B. Roberts, M. B. Sporn: Transforming growth factor ß is a potent immunosuppressive agent that inhibits IL-1 dependent lymphocyte proliferation. J. Immunol. 140 (1988) 3026–3033.

    Google Scholar 

  100. Wolff, K.: Immunorgan Epidermis. Hautarzt 39 (1988) 534–543.

    Google Scholar 

  101. Wolff, K., G. Stingl: The Langerhans cell. J. Invest. Dermatol. (Suppl.) 80 (1983) 17s–21s.

    Article  Google Scholar 

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Macher, E. (1993). Die Haut als immunologisch aktives Organ. In: Medikamentöse Therapie im Kindesalter. Die Haut als immunologisch aktives Organ. Nordrhein-Westfälische Akademie der Wissenschaften. VS Verlag für Sozialwissenschaften, Wiesbaden. https://doi.org/10.1007/978-3-663-00206-2_3

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  • DOI: https://doi.org/10.1007/978-3-663-00206-2_3

  • Publisher Name: VS Verlag für Sozialwissenschaften, Wiesbaden

  • Print ISBN: 978-3-663-00056-3

  • Online ISBN: 978-3-663-00206-2

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