Zusammenfassung
Die Wissenschaft lernt, das Altern besser zu verstehen. Die Lebensspanne hat sich in den letzten 100 Jahren significant erhöht; das wurde vor allem durch bessere Beherrschung von Krankheiten möglich. Der Übergang zum Studium der Faktoren, die das Altern selbst bestimmen, wird erst heute vollzogen. Hier werden große Fortschritte erwartet, die sich in körperlich und geistig gesundem höheren Alter für viele Menschen niederschlagen. Dabei sollen die maximale Lebensspanne deutlich erhöht sowie Verjüngung und Regeneration dabei ermöglicht werden. Das ökonomische Potenzial auf diesem Gebiet ist unermesslich hoch. In nicht allzu ferner Zukunft werden große Teile der Gesellschaft in hoch entwickelten Ländern mit kapitalkräftigem Publikum weit über 100 Jahre alt sein und neue Rollen und gesellschaftliche Akzeptanz finden müssen.
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Literatur
Allison DB, Antoine LH, Ballinger SW et al (2014) Aging and energetics’ ‘Top 40’ future research opportunities 2010–2013. F1000Research 3:219. https://doi.org/10.12688/f1000research.5212.1
Barbi E, Lagona F, Marsili M, Vaupel JW, Wachter KW (2018) The plateau of human mortality: demography of longevity pioneers. Science 360:1459–1461. https://doi.org/10.1126/science.aat3119
Barzilai N, Crandall JP, Kritchevsky SB, Espeland MA (2015) Metformin as toll to target aging. Cell Metab 23(6):1060–1065. https://doi.org/10.1016/j.cmet.2016.05.011
Bitto A, Kaeberlein M (2014) Rejuvenation: It’s in our blood. Cell Metab 20(1):2–4. https://doi.org/10.1016/j.cmet.2014.06.007
Bonkowski MS, Sinclair DA (2016) Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds. Nat Rev Mol Cell Biol 17:679–690. https://doi.org/10.1038/nrm.2016.93
Cadar C (2018) Using Nanoscale robots to fight aging and disease. https://www.lifespan.io/news/using-nanoscale-robots-to-fight-aging-and-disease/
Campbell JM, Bellman SM, Stephenson MD, Lisy K (2017) Metformin reduces all-cause mortality and diseases of ageing independent of its effect on diabetes control: a systematic review and meta-analysis. Ageing Res Rev 40:31–44. https://doi.org/10.1016/j.arr.2017.08.003
Colangelo M (2019) The longevity industry will be the biggest and most complex industry in human history. https://www.linkedin.com/pulse/longevity-industry-biggest-most-complex-human-history-colangelo
Dankwa-Mullan I, Rivo M, Sepulveda M, Park Y, Rhee K (2019) Transforming Diabetes Care through artificial intelligence: the future is here. Popul Health Manag 22(3):229–242. https://doi.org/10.1089/pop.2018.0129
de Grey A (2018) Living to 1000 years old (YouTube, 2020) https://www.youtube.com/watch?v=ZkMPZ8obByw
de Grey A (2017) Can Humans Live for 1000 Years? – Rejuvenation Biology Says Yes – Aubrey de Grey (YouTube) https://www.youtube.com/watch?v=EGZzHfXCyXQ
Donner S (2021) Endlager Mensch. Wie Schadstoffe unsere Gesundheit belasten. Rowohlt Taschenbuch Verlag, Hamburg
Enriquez J, Gullans S (2016) Evolving ourselves. Redesigning the future of humanity – one Gene at a time. Penguin Random House, New York
Fahy GM, Brooke RT, Watson JP, Good Z, Vasanawala SS, Maecker H, Leipold MD, Lin DTS, Kobor MS, Horvath S (2019) Reversal of epigenetic aging and immunosenescent trends in humans. Aging Cell 18. https://doi.org/10.1111/acel.13028
Fillard J-P (2020) Longevity in the 2.0 World. Would Centenarians become commonplace? Word Scientific. Singapore
Geddes L (2016) Human age limit claim sparks debate. Analysis suggests people will never live much beyond 115 but some scientists say that it's too soon to assume a fixed shelf-life. Nature news. 5. Okt. 2016. https://www.nature.com/news/human-age-limit-claim-sparks-debate-1.20750
Glenn JC, Florescu E, The Millennium Project Team (2017) State of the Future version 19.1. http://www.millennium-project.org/state-of-the-future-version-19-1/
Greenstone M, Fan C (2020) Air Quality Life Index (AQLI). Energy Policy Institute at the University of Chicago (EPIC). https://aqli.epic.uchicago.edu/wp-content/uploads/2020/07/AQLI_2020_Report_FinalGlobal-1.pdf
Henrich J (2017) The Secret of our success. How culture is driving human evolution, domesticating our species, and making us smarter. Princeton University Press, Princeton
Hescheler J (2019) Stem cells for regenerative medicine and anti-aging. J Stem Cells Regen Med 15(2):53. https://doi.org/10.46582/jsrm.1502011
Groff L (2015) Future human evolution and views of the future human; Technological perspectives and challenges. World Future Rev 7(2–3):137–158
Harari YN (2017) Homo Deus. Eine Geschichte von morgen. Beck, München. Engl. (2015) Homo Deus. A brief history of tomorrow. Vintage, London
Harrison D, Strong R, Sharp Z et al (2009) Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature 460:392–395. https://doi.org/10.1038/nature08221
International Longevity Alliance (2020) The proposal of the international longevity alliance to classify aging as a disease in IDC-10 has been partially implemented by the world health organisation. http://longevityalliance.org/?q=agingicd11
Irrgang B (2020) Roboterbewusstsein, automatisches Entscheiden und Transhumanismus. Anthropomorphisierungen von KI im Licht evolutionär-phänomenologischer Leib-Anthropologie. Königshausen und Neumann, Würzburg
Johnson SC, Rabinovitch PS, Kaeberlein M (2013) mTOR is a key modulator of ageing and age-related disease. Nature 493:338–345. https://doi.org/10.1038/nature11861
Kenyon CJ (2010) The genetics of ageing. Nature 464(7288):504–612. https://doi.org/10.1038/nature08980
Kurzweil R (2014) Menschheit 2.0 – Die Singularität naht. 2. durchges. Aufl. Lola books, Berlin. Engl. (2005) The singularity is near: when humans transcend biology. Viking Press, New York
Mitchell C, Hobcraft C, McLanahan SS, Siegel SR, Berg A, Brooks-Gunn J, Garfinkel I, Notterman D (2014) Social disadvantage, genetic sensitivity, and children’s telomere length. PNAS 111:5944–5949. https://doi.org/10.1073/pnas.1404293111
Moskalev AA, Proshkina EN, Belyi AA, Solovyev IA (2017) Genetics of Aging and Longevity. Russ J Genet 8:369–384
Nagel T (2016) Geist und Kosmos: Warum die materialistische neodarwinistische Konzeption der Natur so gut wie sicher falsch ist. Suhrkamp, Berlin. Engl. (2012) Mind and Cosmos: Why materialist Neo-Darwinian conception of nature is almost certainly false. Oxford University Press, Oxford
Noble D (2006) The music of life. Biology beyond genes. Oxford University Press, Oxford
Oeppen J, Vaupel JJ (2002) Broken limits to life expectancy. Science 296(5570):1029–1031. https://doi.org/10.1126/science.1069675
Patnaik K (1994) Aging in reptiles. Gerontology 40(2–4):200–220. https://doi.org/10.1159/000213588
Piraino S, Boero F (1996) Reversing the life cycle: Medusae transforming into polyps and cell transdifferentiation in Turritopsis nutricula (Cnidaria, Hydrozoa). Biol Bull 190:302–312
PwC PricewaterhouseCoopers (2016) Five megatrends and their implications for global defense & security. https://www.pwc.com/gx/en/government-public-services/assets/five-megatrends-implications.pdf
Rajman CK, Sinclair DA (2018) Therapeutic potential of NAD-boosting molecules: the in vivo evidence. Cell Metab 27(3):529–547. https://doi.org/10.1016/j.cmet.2018.02.011
Riesewieck M, Block H (2020) Die digitale Seele. Unsterblichkeit im Zeitalter künstlicher Intelligenz. Goldmann, München
Roser M, Ortiz-Ospina E, Ritchie H (2019) Life expectancy. OurWorldInData.org. https://ourworldindata.org/life-expectancy
Ruby JG, Wright KM, Rand KA, Kermany A, Noto K, Curtis D, Varner N, Garrigan D, Slinkov D, Dorfman I, Granka JM, Byrnes J, Myres N, BallC (2018a) Estimates of the heritability of human longevity are substantially inflated due to assortative mating genetics 2018:1109–1124. https://doi.org/10.1534/genetics.118.301613
Ruby JG, Smith M, Buffenstein R (2018b) Naked mole-rat mortality rates defy Gompertzian laws by not increasing with age. eLife 7:e31157. doi: https://doi.org/10.7554/eLife.31157
Sarkar TJ, Quarta M, Mukherjee S, Colville A, Paine P, Doan L, Tran CM, Chu CR, Horvath S, Bhutani N, Rando TA, Sebastiano V (2020) Transient non-integrative expression of nuclear reprogramming factors promotes multifaceted amelioration of aging in human cells. Nat Commun 11:1545. https://doi.org/10.1038/s41467-020-15174-3
Schaible R, Scheuerlein A, Dańko MJ, Gampe J, Martínez DE, Vaupel JV (2015) Constant mortality and fertility over age in Hydra. PNAS 112:15701–15706. https://doi.org/10.1073/pnas.1521002112
Schürle-Finke S (2019) Nanosystem für die personalisierte Medizin. In: Böttinger E und Putlitz J zu (2019) Die Zukunft der Medizin. Medizinisch Wissenschaftliche Verlagsgesellschaft, Berlin, 95–101
Shin-Hae L, Ji-Hyeon L, Hye-Yeon L, Kyung-Min M (2019) Sirtuin signaling in cellular senescence and aging. BMB Rep 52:24–34. https://doi.org/10.5483/BMBRep.2019.52.1.290
Singh PP, Demmitt BA, Nath RV, Brunet A (2019) The genetics of aging: a vertebrate perspective. Cell 17:200–220. https://doi.org/10.1016/j.cell.2019.02.038
The Guardian (2017) Elizabeth Blackburn on the telomere effect: ‘It’s about keeping healthier for longer’ (30.1. 2017)
Ullah M, Sun Z (2018) Stem cells and anti-aging genes: double-edged sword—do the same job of life extension. Stem Cell Res Ther 9:3. https://doi.org/10.1186/s13287-017-0746-4
United Nations (2017) World population ageing. Highlights, New York
Urfer SR, Kaeberlein TL, Mailheau S, Bergman PJ, Creevy KE, Promislow DE, Kaeberlein M (2017) A randomized controlled trial to establish effects of short-term rapamycin treatment in 24 middle-aged companion dogs. GeroScience 39(2):117–127
Vaiserman A, de Falco E, Koliada A, Masiova O, Balistreri CR (2019) Anti-ageing gene therapy: not so far away? Ageing Res Rev 56. https://doi.org/10.1016/j.arr.2019.100977
Vogel G (2000) In contrast to Dolly, cloning resets telomere clock in Cattle. Science 288:586–587
Welsch N (2015) Leben ohne Tod? Forscher besiegen das Altern. Springer Spektrum, Berlin
Whittemore K, Vera E, Martínez-Nevado E, Sanpera C, Blasco MA (2019) Telomere shortening rate predicts species life span. PNAS 116:15122–15127. https://doi.org/10.1073/pnas.1902452116
Wilhelm K (2020) Der Methusalem Cocktail. Max Planck Forschung 1:2020:56–61. Berlin
Zhavoronkov A (2019) Longevity vision fund: fueling the longevity biotechnology boom We’ve been waiting for. Forbes. https://www.forbes.com/sites/cognitiveworld/2019/02/04/longevity-vision-fund-fueling-the-longevity-biotechnology-boom-weve-been-waiting-for/#547b4f8a38e5
Zhavoronkov A, Mamoshina P (2019) Deep aging clocks: the emergence of AI-Based biomarkers of aging and longevity. Sci Soc Speci Rise of Machin Medi 40:546–549. https://doi.org/10.1016/j.tips.2019.05.004
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Lange, A. (2021). Immer älter – von Methusalem-Genen bis Verjüngung und Unsterblichkeit. In: Von künstlicher Biologie zu künstlicher Intelligenz - und dann?. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-63055-6_9
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